Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells

scientific article published on November 1996

Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.16.11.6178
P932PMC publication ID231621
P698PubMed publication ID8887648
P5875ResearchGate publication ID14318581

P2093author name stringP M Pitha
J Taylor-Papadimitriou
J Ye
R H Xu
P2860cites workCloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expressionQ24337872
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumorsQ24339400
Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1Q24562924
Signal transduction by receptors with tyrosine kinase activityQ27860624
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteinsQ27861094
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domainQ28295806
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancerQ28678776
Integrins and signal transduction pathways: the road takenQ29547895
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformationQ29616396
Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motifQ29620290
The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory elementQ33290801
Cell adhesion molecules in the normal and cancerous mammary glandQ33962782
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomasQ34053843
Growth factor receptor tyrosine kinasesQ34164164
Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elementsQ34164797
In vivo sequence requirements of the SV40 early promoter regionQ34252254
Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1Q34356853
Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppressionQ34396889
The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinomaQ34725896
A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activationQ34920038
E-cadherin gene mutations in human gastric carcinoma cell linesQ35078532
Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin geneQ35621568
Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breastQ35811674
Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.Q36556065
Characterization of the human granulocyte-macrophage colony-stimulating factor gene promoter: an AP1 complex and an Sp1-related complex transactivate the promoter activity that is suppressed by a YY1 complexQ36556726
Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activityQ36644521
Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-RelQ36700950
Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirusQ37490464
A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathwayQ37634563
Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivoQ38292759
The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulatorQ38306731
The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expressionQ38511506
Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signalingQ40015717
Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1Q40016208
Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcriptionQ40019025
Sp1-mediated transcriptional activation is repressed by Sp3Q40792899
Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-JunQ41343659
Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation.Q41345363
Intermolecular association and trans-phosphorylation of different neu-kinase forms permit SH2-dependent signaling and oncogenic transformationQ41381709
Branching morphogenesis of human mammary epithelial cells in collagen gels.Q41425737
Characterization of a silencer regulatory element in the human interferon-gamma promoterQ41435938
Elevated production of active oxygen in Bloom's syndrome cell lines.Q41517593
Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: implications for mammary tumorsQ41518535
Collagen-induced morphogenesis and expression of the alpha 2-integrin subunit is inhibited in c-erbB2-transfected human mammary epithelial cells.Q41546066
Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversionQ41589126
Regulation of smooth muscle alpha-actin promoter in ras-transformed cells: usefulness for setting up reporter gene-based assay system for drug screeningQ41589552
Activation of human immunodeficiency virus type 1 provirus in T-cells and macrophages is associated with induction of inducer-specific NF-kappa B binding proteinsQ41638013
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinaseQ41718635
Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridizationQ42755037
bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cellsQ42771375
Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.Q42826357
Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.Q43554604
Transcription from a TATA-less promoter requires a multisubunit TFIID complexQ46109338
Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancerQ46975204
Amplification of a novel v-erbB-related gene in a human mammary carcinomaQ48375434
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomasQ71804951
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)6178-6189
P577publication date1996-11-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleSp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells
P478volume16

Reverse relations

described by source (P1343)
Q54907018MTSV1-7
Q54399840MTSV1-7 HB2
Q102114562MTSV1-7 HB2-Erb-B2
Q102114565MTSV1-7 HB2-Ras
Q102114564MTSV1-7 HB2-neo
Q54907025MTSV1-7 ce1

cites work (P2860)
Q36274882A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling
Q40615077Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells
Q40975184Activation of Sp1 and its functional co-operation with serum amyloid A-activating sequence binding factor in synoviocyte cells trigger synergistic action of interleukin-1 and interleukin-6 in serum amyloid A gene expression
Q40849400Activation of the alpha2beta1 integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen
Q36736295Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition
Q38399277C-reactive protein binds to integrin α2 and Fcγ receptor I, leading to breast cell adhesion and breast cancer progression
Q38301697Characterization of Inherited Differences in Transcription of the Human Integrin alpha 2 Gene
Q39575631Cloning and characterization of a GC-box binding protein, G10BP-1, responsible for repression of the rat fibronectin gene
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Q52176541Factors involved in GLUT-1 glucose transporter gene transcription in cardiac muscle.
Q56217286Genetic Polymorphisms of Platelet Adhesive Molecules: Association with Breast Cancer Risk and Clinical Presentation
Q44739067Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen
Q39584026Induction of Sp1 in differentiating human embryonal carcinoma cells triggers transcription of the fibronectin gene
Q40718516Induction or suppression of expression of cytochrome C oxidase subunit II by heregulin beta 1 in human mammary epithelial cells is dependent on the levels of ErbB2 expression
Q42494351Involvement of Sp1 in the transcriptional regulation of the rat insulin-like growth factor-1 gene
Q42476459Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene
Q23911300Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro
Q28115670Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation
Q38320011Selective Sp1 and Sp3 binding is crucial for activity of the integrin alphaV promoter in cultured endothelial cells
Q41040349Sp1 cooperates with the ets transcription factor, GABP, to activate the CD18 (beta2 leukocyte integrin) promoter
Q42485182Sp1/Sp3 and PU.1 differentially regulate beta(5) integrin gene expression in macrophages and osteoblasts
Q37339461Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer
Q33778355The Sp-family of transcription factors
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Q73694178The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter
Q57385092The α2 and α5 integrin genes: identification of transcription factors that regulate promoter activity in epidermal keratinocytes
Q34042666Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway
Q78732223Transcriptional control of the RECK metastasis/angiogenesis suppressor gene
Q41756422Transcriptional regulation by the Sp family proteins.
Q30661634Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue
Q39988748α2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5.