α2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5.

scientific article

α2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1155/2011/365651
P932PMC publication ID3245846
P698PubMed publication ID22203845
P5875ResearchGate publication ID51954212

P2093author name stringSteve Goodison
Grace Lin
Chia-Yao Lee
Steve Silletti
David Marzan
P2860cites workPrognostic implications of the immunohistochemical expression of human kallikreins 5, 6, 10 and 11 in renal cell carcinoma.Q53805326
Expression and function of receptors for extracellular matrix proteins in human ductal adenocarcinomas of the pancreasQ60609806
Characterization of integrin chains in normal and neoplastic human pancreasQ67704652
Altered expression of extracellular matrix molecules and their receptors in chronic pancreatitis and pancreatic adenocarcinoma in comparison with normal pancreasQ71261083
Integrin alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagenQ73115582
Fibronectin provides a conduit for fibroblast transmigration from collagenous stroma into fibrin clot provisional matrixQ73303260
Role of the alpha1 and alpha2 integrin cytoplasmic domains in cell morphology, motility and responsiveness to stimulation by the protein kinase C pathwayQ73542087
Increased gene expression levels of collagen receptor integrins are associated with decreased survival parameters in patients with advanced melanomaQ80599272
Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasionQ81098053
The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent mannerQ24555127
Differential expression of Kallikrein gene 5 in cancerous and normal testicular tissuesQ28208251
Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissuesQ28214483
KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancerQ28239690
Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherinQ28292665
A synthetic tissue kallikrein inhibitor suppresses cancer cell invasivenessQ28363391
Kallikrein gene downregulation in breast cancerQ30438640
Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptorsQ33923778
Pancreatic cancer biology and geneticsQ35013204
Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breastQ35811674
Widespread histologic distribution of the alpha 2 beta 1 integrin cell-surface collagen receptorQ35812048
Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastasesQ35831011
Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cellsQ36563516
The alpha2beta1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell linesQ36614617
Tissue kallikrein proteolytic cascade pathways in normal physiology and cancerQ36880603
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.Q37216669
Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasionQ37462704
Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the boneQ40236421
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activityQ40515725
Specific residues within the alpha 2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathwaysQ40797356
Pancreatic carcinomas deposit laminin-5, preferably adhere to laminin-5, and migrate on the newly deposited basement membraneQ41080922
Adhesion molecules in breast cancer: role of alpha 2 beta 1 integrinQ41726199
Expression and distribution of VLA receptors in the pancreas: an immunohistochemical studyQ42503388
Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosisQ42822881
Chronologically-specific metastatic targeting of human pancreatic tumors in orthotopic modelsQ42829581
Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell linesQ43579752
Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinomaQ43777686
Fibrinogen and fibrin are anti-adhesive for keratinocytes: a mechanism for fibrin eschar slough during wound repair.Q43910766
HER2 overexpression correlates with survival after curative resection of pancreatic cancer.Q46016285
Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic functionQ46829746
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectadenocarcinomaQ356033
pancreatic adenocarcinomaQ18556189
P304page(s)365651
P577publication date2011-12-13
P1433published inJournal of oncologyQ26853876
P1476titleα2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5.
P478volume2011

Reverse relations

cites work (P2860)
Q56519341Candidate agents for pancreatic ductal adenocarcinoma identified by a sub-pathway based method
Q55508822Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p.
Q34781039Kallikrein-related peptidase 5 induces miRNA-mediated anti-oncogenic pathways in breast cancer
Q34590459PRL-3 suppresses c-Fos and integrin α2 expression in ovarian cancer cells
Q35176601Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of α2β1 integrin and E-cadherin function.
Q35634200Recombinant disintegrin (r-Cam-dis) from Crotalus adamanteus inhibits adhesion of human pancreatic cancer cell lines to laminin-1 and vitronectin.

Search more.