Activation of the alpha2beta1 integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen

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Activation of the alpha2beta1 integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1025582164
P356DOI10.1038/SJ.ONC.1203792
P698PubMed publication ID11030148
P5875ResearchGate publication ID12294525

P2093author name stringTaylor-Papadimitriou J
Baeckström D
Lu PJ
P2860cites workNovel monoclonal antibodies defining epitope of human cytokeratin 18 moleculeQ69048091
The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitorsQ71524901
C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cellsQ77293332
Selective increase of alpha2-integrin sub-unit expression on human carcinoma cells upon EGF-receptor activationQ77959283
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimersQ28679173
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalingQ33886341
Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin geneQ35621568
Laminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cellsQ36136193
Motogenic and morphogenic activity of epithelial receptor tyrosine kinasesQ36236949
Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cellsQ36563516
ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cellsQ36621254
Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinaseQ36907061
Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirusQ37490464
The neu-protein and breast cancerQ40529932
Expression of the activated p185erbB2 tyrosine kinase in human epithelial cells leads to MAP kinase activation but does not confer oncogenicityQ41120768
Signaling by epidermal growth factor differentially affects integrin-mediated adhesion of tumor cells to extracellular matrix proteinsQ41161364
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cellsQ41164260
The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactionsQ41554100
Adhesion of T and B lymphocytes to extracellular matrix and endothelial cells can be regulated through the beta subunit of VLAQ41631040
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathwayQ42618265
Histopathological evaluation of apoptosis in cancerQ42850802
Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytesQ57385115
P433issue40
P407language of work or nameEnglishQ1860
P304page(s)4592-4603
P577publication date2000-09-01
P1433published inOncogeneQ1568657
P1476titleActivation of the alpha2beta1 integrin prevents c-erbB2-induced scattering and apoptosis of human mammary epithelial cells in collagen
P478volume19

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cites work (P2860)
Q39104059Cytogenetic characterization of HB2 epithelial cells from the human breast
Q34603045Integrins in invasive growth
Q38997298Loss of E-cadherin expression is not a prerequisite for c-erbB2-induced epithelial-mesenchymal transition
Q40415899PKB mediates c-erbB2-induced epithelial beta1 integrin conformational inactivation through Rho-independent F-actin rearrangements
Q38350119The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression.
Q24801456The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion.
Q40366552Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology
Q33903097c-erbB2-induced disruption of matrix adhesion and morphogenesis reveals a novel role for protein kinase B as a negative regulator of alpha(2)beta(1) integrin function

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