Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells

scientific article published on 22 November 2006

Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M606203200
P698PubMed publication ID17124180

P2093author name stringPierre-Olivier Estève
Sriharsa Pradhan
Hang Gyeong Chin
P2860cites workDNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulationQ24296741
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphomaQ24322614
Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferasesQ24534264
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcriptionQ24534441
The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activityQ24536177
Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machineryQ24562316
Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityQ28131773
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promotersQ28140428
DNA methyltransferase Dnmt1 associates with histone deacetylase activityQ28141500
DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsQ28212826
Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathwayQ28215330
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factorQ28217975
De novo CpG island methylation in human cancer cellsQ28292684
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domainQ28295806
Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylationQ28609169
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cellsQ29547557
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
Partitioning and plasticity of repressive histone methylation states in mammalian chromatinQ29614513
Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motifQ29620290
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activityQ31038912
Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promotersQ33732110
Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancerQ33952921
Mammalian DNA (cytosine-5) methyltransferases and their expressionQ34273147
Inhibition of melanoma tumor growth in vivo by survivin targetingQ34623127
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.Q34888585
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancersQ35083484
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.Q35207550
Epigenetic changes in colorectal cancer.Q35682096
Chromatin modifying activity of leukaemia associated fusion proteinsQ36088954
Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor proteinQ38300297
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiationQ38345845
DNA damage-induced down-regulation of human Cdc25C and Cdc2 is mediated by cooperation between p53 and maintenance DNA (cytosine-5) methyltransferase 1.Q40261691
CpG islands and genesQ40406688
Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: importance for the regulation of genes involved in cell-cycle arrest and apoptosisQ40442787
Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.Q40543122
Independent repression of a GC-rich housekeeping gene by Sp1 and MAZ involves the same cis-elementsQ40819762
Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1.Q41094631
Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcriptionQ41684614
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinaseQ41718635
Sp1 elements protect a CpG island from de novo methylationQ42497349
The same nuclear proteins bind the proximal CACCC box of the human beta-globin promoter and a similar sequence in the enhancerQ43571710
Transcription from a TATA-less promoter requires a multisubunit TFIID complexQ46109338
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.Q50335767
Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia.Q52087420
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)2615-2625
P577publication date2006-11-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleMolecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells
P478volume282

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cites work (P2860)
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