The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development

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The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M306425200
P698PubMed publication ID12882970

P50authorMathias MericskayQ56892299
Kylie M GeorgasQ114400304
Melissa LittleQ41179909
David SassoonQ42667418
P2093author name stringIsabelle Gross
Patricia D Wilson
Jonathan D Licht
Debra J Morrison
Deborah P Hyink
Seiyu Hosono
Milton A English
P2860cites workCRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesisQ22011105
WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosisQ24292676
Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expressionQ24316570
sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airwaysQ24336220
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteinsQ24534190
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signallingQ24534484
Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesisQ28144856
Sprouty, an intracellular inhibitor of Ras signaling.Q52569025
Wilms tumor and the WT1 geneQ28203445
Morpholino antisense oligomers: design, preparation, and propertiesQ28243074
WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblastsQ28505651
Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activationQ28505657
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formationQ28509874
WT-1 is required for early kidney developmentQ28512266
Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesisQ28585209
Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesisQ28592618
Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cellsQ28609619
Kidney morphogenesis: cellular and molecular regulationQ33855366
The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulinQ33874404
Cross-talk in kidney developmentQ34026941
Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.Q34100782
The candidate Wilms' tumour gene is involved in genitourinary developmentQ34189819
Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.Q34460141
Identifying differences in mRNA expression by representational difference analysis of cDNAQ35004368
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1Q36560249
Sequence and structural requirements for high-affinity DNA binding by the WT1 gene productQ38298155
Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth controlQ38325277
Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequenceQ38338176
Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterningQ40423955
WT1 regulates the expression of the major glomerular podocyte membrane protein PodocalyxinQ40767021
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activationQ40787356
Analysis of WT1 target gene expression in stably transfected cell linesQ41002837
Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.Q41084039
Growth factor requirements of organogenesis in serum-free metanephric organ cultureQ41385346
Detection of messenger RNA by in situ hybridization.Q41587073
E-cadherin is a WT1 target geneQ42832537
Polypeptide growth factors in metanephric growth and segmental nephron differentiationQ44118632
mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteinsQ44133728
A novel method for real time quantitative RT-PCR.Q46544663
Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryoQ47963291
The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.Q48369257
Exogenous FGF-4 can suppress anterior development in the mouse embryo during neurulation and early organogenesis.Q52169044
Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling.Q52170367
Architectural patterns in branching morphogenesis in the kidney.Q52567180
P433issue42
P407language of work or nameEnglishQ1860
P304page(s)41420-41430
P577publication date2003-07-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development
P478volume278