Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control

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Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.19.13258
P698PubMed publication ID10224085
P5875ResearchGate publication ID13074545

P2093author name stringEnglish MA
Licht JD
P2860cites workInduction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibitionQ22003911
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70Q24308507
Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2Q24309088
Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1Q24309269
High affinity binding sites for the Wilms' tumour suppressor protein WT1Q24314245
Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9Q24322684
A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1Q24324095
WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomesQ24596062
Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 AQ27660274
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locusQ28236741
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumpingQ28236877
WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblastsQ28505651
WT-1 is required for early kidney developmentQ28512266
Truncated WT1 mutants alter the subnuclear localization of the wild-type proteinQ33635997
Antagonism of WT1 activity by protein self-association.Q33756936
G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexesQ34341142
Regulation of ornithine decarboxylase gene expression by the Wilms' tumor suppressor WT1.Q34592669
A clinical overview of WT1 gene mutationsQ34738955
A rodent model for Wilms tumors: embryonal kidney neoplasms induced by N-nitroso-N'-methylureaQ35823348
Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene productQ36378010
A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1Q36560249
Selective repression of transcriptional activators at a distance by the Drosophila Krüppel proteinQ36702540
RNA binding by the Wilms tumor suppressor zinc finger proteins.Q37426489
Alternative splicing and genomic structure of the Wilms tumor gene WT1Q37611742
Repression of the c-myb gene by WT1 protein in T and B cell linesQ38290555
WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.Q38295546
Sequence and structural requirements for high-affinity DNA binding by the WT1 gene productQ38298155
Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequenceQ38338176
The regulation of IGF-I receptor gene expression.Q40381637
The genetics of Wilms' tumor--a case of disrupted developmentQ40614052
Analysis of WT1 target gene expression in stably transfected cell linesQ41002837
The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomasQ41098050
The genomic organization and expression of the WT1 geneQ41120172
The transcriptional effect of WT1 is modulated by choice of expression vectorQ41259478
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosisQ41302327
Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicingQ41347006
New developments in the pathology of Wilms tumorQ41421689
WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.Q41508164
Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndromeQ41660674
Transcriptional repression mediated by the WT1 Wilms tumor gene productQ41661461
Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital developmentQ52231802
Evidence that WT1 mutations in Denys — Drash syndrome patients may act in a dominant-negative fashionQ59662118
Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcriptQ59662123
Autoregulation of the human WT1 gene promoterQ63722729
Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1Q67493857
Constitutional mutations in the WT1 gene in patients with Denys-Drash syndromeQ67510310
Langer-Giedion syndrome and deletion of the long arm of chromosome 8Q72095894
A novel insertional mutation at the third zinc finger coding region of the WT1 gene in Denys-Drash syndromeQ72220079
Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumourQ72751031
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)13258-13263
P577publication date1999-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleTumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control
P478volume274

Reverse relations

cites work (P2860)
Q42830606A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1.
Q40019105A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.
Q44180520Analytical validation of a real-time reverse transcription-polymerase chain reaction quantitation of different transcripts of the Wilms' tumor suppressor gene (WT1).
Q77378832Forced expression of the Wilms tumor 1 (WT1) gene inhibits proliferation of human hematopoietic CD34(+) progenitor cells
Q30482686In silico regulatory analysis for exploring human disease progression
Q34348689Life, sex, and WT1 isoforms--three amino acids can make all the difference
Q35089301Molecular mechanisms of renal development
Q40648946Oxygen‐regulated expression of the Wilms’ tumor suppressorWt1involves hypoxia‐inducible factor‐1 (HIF‐1)
Q28346512Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1
Q34820024Regulation of gene expression by WT1 in development and tumorigenesis
Q34077533The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells
Q33874404The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin
Q35779420The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1.
Q28576102The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells
Q38352220The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development
Q36831216The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis
Q39371450WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
Q39958704WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression
Q28191433WT1 proteins: functions in growth and differentiation
Q36234726Wilms' tumour: connecting tumorigenesis and organ development in the kidney

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