Life, sex, and WT1 isoforms--three amino acids can make all the difference

scientific article

Life, sex, and WT1 isoforms--three amino acids can make all the difference is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0092-8674(01)00469-X
P698PubMed publication ID11525724

P2093author name stringHastie ND
P2860cites workInitial sequencing and analysis of the human genomeQ21045365
The Sequence of the Human GenomeQ22065842
WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomesQ24596062
Identification of WTAP, a novel Wilms' tumour 1-associating proteinQ28139416
Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicingQ28240533
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formationQ28509874
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hairQ28586758
The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulinQ33874404
The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiationQ33957545
Congenital nephrotic syndromesQ34264623
Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth controlQ38325277
The human sex-determining gene SRY is a direct target of WT1.Q40817158
WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogeneQ41786212
Characterization of RNA aptamer binding by the Wilms' tumor suppressor protein WT1.Q43592618
The genetics and biology of vertebrate sex determination.Q52132958
The Wilms tumor suppressor gene wt1 is required for development of the spleen.Q52174780
WT1: what has the last decade told us?Q60212963
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)391-394
P577publication date2001-08-01
P1433published inCellQ655814
P1476titleLife, sex, and WT1 isoforms--three amino acids can make all the difference
P478volume106

Reverse relations

cites work (P2860)
Q36663300A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation
Q42832130A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus
Q35682898A mutant Ahr allele protects the embryonic kidney from hydrocarbon-induced deficits in fetal programming
Q24303633BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1
Q39686531Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms
Q34160093Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing.
Q44092524Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour
Q44260446Characterization and in vivo functional analysis of splice variants of cypher
Q24316180Characterization of VIK-1: a new Vav-interacting Kruppel-like protein
Q35681535Characterization of conserved tandem donor sites and intronic motifs required for alternative splicing in corticosteroid receptor genes
Q50498732Clinical Aspects of WT1 and the Kidney.
Q27728005Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications
Q92036703Deubiquitinase inhibitor degrasyn suppresses metastasis by targeting USP5-WT1-E-cadherin signalling pathway in pancreatic ductal adenocarcinoma
Q50707897Different isoforms of the Wilms' tumour protein WT1 have distinct patterns of distribution and trafficking within the nucleus.
Q33884209Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family
Q39758710Faithful expression of a tagged Fugu WT1 protein from a genomic transgene in zebrafish: efficient splicing of pufferfish genes in zebrafish but not mice
Q36572920Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice.
Q36395064Mechanisms of Disease: normal and abnormal gonadal development and sex determination in mammals.
Q34784768Mice lacking the 68-amino-acid, mammal-specific N-terminal extension of WT1 develop normally and are fertile
Q34560968Molecular BKology: the study of splicing and dicing
Q24682486RNA binding protein sex-lethal (Sxl) and control of Drosophila sex determination and dosage compensation
Q37010442Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.
Q24798591Selective inhibition of c-Myb DNA-binding by RNA polymers
Q34563355Sex with two SOX on: SRY and SOX9 in testis development.
Q58201231Strain Dependent Rat iNOS Promoter Activity—Correlation to Identified WT1 Transcription Factor Binding Site
Q39129209The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells.
Q44693706The effects of the WT1 gene on apoptosis and development-related gene expression in porcine kidney fibroblasts and swine testis cells.
Q28264516The many facets of the Wilms' tumour gene, WT1
Q38712379Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction
Q52569623Vascular endothelial growth factor (VEGF) is suppressed in WT1-transfected LNCaP cells.
Q37940867WT1 in disease: shifting the epithelial-mesenchymal balance.
Q24300741WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo
Q47369729WT1 loss attenuates the TP53-induced DNA damage response in T-cell acute lymphoblastic leukemia
Q54389479WT1 overexpression affecting clinical outcome in non-hodgkin lymphomas and adult acute lymphoblastic leukemia.
Q37704104Wilms' Tumour gene 1 (WT1) as an immunotherapeutic target
Q24675575Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA