WT1 loss attenuates the TP53-induced DNA damage response in T-cell acute lymphoblastic leukemia

scientific article published on 23 November 2017

WT1 loss attenuates the TP53-induced DNA damage response in T-cell acute lymphoblastic leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3324/HAEMATOL.2017.170431
P932PMC publication ID5792271
P698PubMed publication ID29170254

P50authorAlberto Ambesi-ImpiombatoQ71501192
Elena MasieroQ117812133
P2093author name stringGiuseppe Basso
Valeria Tosello
Paola Zanovello
Alberto Amadori
Roberta Bertorelle
Valeria Sacchetto
Sonia Minuzzo
Erich Piovan
Giorgia Pilotto
Fulvio Bordin
P2860cites workThe genetic basis of early T-cell precursor acute lymphoblastic leukaemiaQ24601515
Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B studyQ27851436
Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working PartyQ27851437
Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemiaQ27851659
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.Q27852067
Puma is an essential mediator of p53-dependent and -independent apoptotic pathwaysQ28213279
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locusQ28236741
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumpingQ28236877
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemiaQ28253465
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferationQ28255707
WT-1 is required for early kidney developmentQ28512266
Physical and functional interaction between WT1 and p53 proteinsQ28575245
Transcriptional control of human p53-regulated genesQ29617650
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemiaQ33733461
Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemiaQ33886181
Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.Q34052581
Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B studyQ34052614
Life, sex, and WT1 isoforms--three amino acids can make all the differenceQ34348689
Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumorQ34557796
Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapseQ35102275
Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancerQ35130362
Analysis of TP53 mutation status in human cancer cell lines: a reassessmentQ35671197
HGVS Recommendations for the Description of Sequence Variants: 2016 UpdateQ35941614
An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenograftsQ36751751
A tumor suppressor and oncogene: the WT1 story.Q36760031
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.Q37250634
WT1 mutations in T-ALLQ37291631
Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemiaQ37322911
Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.Q37351577
WT1 in disease: shifting the epithelial-mesenchymal balance.Q37940867
Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1).Q38220041
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancerQ39144862
Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis proteinQ40233896
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure databaseQ40561637
WT1-p53 interactions in insulin-like growth factor-I receptor gene regulationQ40688483
Embelin sensitizes acute myeloid leukemia cells to TRAIL through XIAP inhibition and NF-κB inactivationQ42182512
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.Q45062542
Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts.Q45735200
Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignancies.Q47268104
Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.Q51788134
Recent advances in acute lymphoblastic leukemia.Q53423186
Cooperative genetic defects in TLX3 rearranged pediatric T-ALL.Q53506137
Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance.Q54138925
WT1 mutations are secondary events in AML, show varying frequencies and impact on prognosis between genetic subgroups.Q54331723
Clinical relevance of molecular aberrations in paediatric acute myeloid leukaemia at first relapse.Q54342441
Wilms' tumor 1 mutation accumulated during therapy in acute myeloid leukemia: biological and clinical implicationsQ59194331
Genetic interactions between the Wilms' tumor 1 gene and the p53 geneQ78532808
Mutant Wilms' tumor 1 (WT1) mRNA with premature termination codons in acute myeloid leukemia (AML) is sensitive to nonsense-mediated RNA decay (NMD)Q82269123
Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemiaQ83244976
P433issue2
P921main subjectleukemiaQ29496
P304page(s)266-277
P577publication date2017-11-23
P1433published inHaematologicaQ5638209
P1476titleWT1 loss attenuates the TP53-induced DNA damage response in T-cell acute lymphoblastic leukemia
P478volume103

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cites work (P2860)
Q89655650Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia
Q97522002Novel Genetic Variations in Acute Myeloid Leukemia in Pakistani Population
Q91743034WITER: a powerful method for estimation of cancer-driver genes using a weighted iterative regression modelling background mutation counts

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