WT1 in disease: shifting the epithelial-mesenchymal balance.

scientific article published on 29 September 2011

WT1 in disease: shifting the epithelial-mesenchymal balance. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/PATH.2977
P698PubMed publication ID21959952
P5875ResearchGate publication ID51682139

P50authorPeter HohensteinQ41783681
P2093author name stringEve Miller-Hodges
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosisQ24292676
PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expressionQ24296236
Regeneration of glomerular podocytes by human renal progenitorsQ24308871
Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescenceQ24309539
WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomesQ24596062
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/OmiQ24655084
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locusQ28236741
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumpingQ28236877
WT1 and glomerular diseasesQ28259503
The many facets of the Wilms' tumour gene, WT1Q28264516
WT1 the oncogene: a tale of death and HtrAQ28272033
WAGR syndrome: a clinical review of 54 casesQ28275152
The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomesQ28505624
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4Q28508296
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formationQ28509874
WT-1 is required for early kidney developmentQ28512266
A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndromeQ28584838
The Wilms' tumor gene Wt1 is required for normal development of the retinaQ28590668
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathwaysQ29615855
Evidence that fibroblasts derive from epithelium during tissue fibrosisQ29616581
A high-powered view of the filtration barrierQ30665384
Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's diseaseQ30975987
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisQ33556248
De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular diseaseQ33727815
Antagonism of WT1 activity by protein self-association.Q33756936
A novel WT1 gene mutation in a three-generation family with progressive isolated focal segmental glomerulosclerosisQ33769998
Presence of WT1, the Wilm's tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoproteinQ33883341
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumorQ34189532
The candidate Wilms' tumour gene is involved in genitourinary developmentQ34189819
Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.Q34248627
Epidemiology of Wilms tumorQ34305834
Life, sex, and WT1 isoforms--three amino acids can make all the differenceQ34348689
Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation databaseQ34385164
Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylationQ34428960
Donor splice-site mutations in WT1 are responsible for Frasier syndromeQ34449327
A clinical overview of WT1 gene mutationsQ34738955
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon geneQ35095712
CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumorsQ35103587
TGF-beta1 reduces Wilms' tumor suppressor gene expression in podocytesQ35218235
A new aspect of the molecular pathogenesis of paroxysmal nocturnal hemoglobinuriaQ35670980
New insights into epithelial-mesenchymal transition in kidney fibrosisQ36010095
Transcriptional regulation by WT1 in development.Q36229114
Wilms' tumour: connecting tumorigenesis and organ development in the kidneyQ36234726
Surveillance for Wilms tumour in at-risk children: pragmatic recommendations for best practiceQ36542374
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuriaQ36559707
The Wnt/beta-catenin pathway in Wilms tumors and prostate cancersQ36907358
Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development.Q36938543
Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transitionQ36985824
Recruitment of podocytes from glomerular parietal epithelial cellsQ37086632
New insights into the function of the Wilms tumor suppressor gene WT1 in podocytesQ37127104
Role of the Wilms' tumour transcription factor, Wt1, in blood vessel formationQ37340320
RNA binding by the Wilms tumor suppressor zinc finger proteins.Q37426489
Effects of TGF-beta on podocyte growth and disease progression in proliferative podocytopathiesQ37698872
WT1 (Wilms' tumor gene 1): biology and cancer immunotherapyQ37731720
The molecular mediators of type 2 epithelial to mesenchymal transition (EMT) and their role in renal pathophysiology.Q37760963
Activation of the TGF-beta/Smad signaling pathway in focal segmental glomerulosclerosisQ38519222
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesodermQ39747265
Actin: a novel interaction partner of WT1 influencing its cell dynamic propertiesQ39766194
Mechanisms of angiotensin II signaling on cytoskeleton of podocytesQ39942955
The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cellsQ39953304
Wilms' tumor protein (-KTS) modulates renin gene transcription.Q39979771
Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney developmentQ40146414
The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1.Q40484861
The Wilms’ tumour suppressor protein, WT1, undergoes CRM1‐independent nucleocytoplasmic shuttlingQ40620494
Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1.Q40722568
WT1 regulates the expression of the major glomerular podocyte membrane protein PodocalyxinQ40767021
Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicingQ41347006
Sequential WT1 and CTNNB1 mutations and alterations of beta-catenin localisation in intralobar nephrogenic rests and associated Wilms tumours: two case studiesQ41809711
Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2.Q42052856
Different CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutationQ42550921
Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.Q42945812
A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repressionQ43221537
The wt1-heterozygous mouse; a model to study the development of glomerular sclerosisQ44536833
Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosisQ44547374
Characteristics and outcomes of children with the Wilms tumor-Aniridia syndrome: a report from the National Wilms Tumor Study GroupQ44573108
Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF165b) mRNA and proteinQ44673718
Expression of Wilms' tumor suppressor in the liver with cirrhosis: relation to hepatocyte nuclear factor 4 and hepatocellular functionQ45863258
Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesisQ46889320
Functional symbiosis between endothelium and epithelial cells in glomeruliQ46902679
The dysregulated glomerular cell growth in Denys-Drash syndromeQ47251228
Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndromeQ47813520
The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.Q48369257
The eponym "Wilms": a reminder of a surgeon's lifelong contributions to medicineQ50253196
Small glomeruli in WAGR (Wilms Tumor, Aniridia, Genitourinary Anomalies and Mental Retardation) syndrome.Q51903202
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.Q51933152
Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.Q52097211
The Wilms tumor suppressor gene wt1 is required for development of the spleen.Q52174780
YAC transgenic analysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb.Q52176765
Management of Wilms tumors in Drash and Frasier syndromes.Q53208087
Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy.Q54472919
WT1 mutations in Meacham syndrome suggest a coelomic mesothelial origin of the cardiac and diaphragmatic malformationsQ55671351
P433issue2
P304page(s)229-240
P577publication date2011-09-29
P1433published inJournal of PathologyQ400296
P1476titleWT1 in disease: shifting the epithelial-mesenchymal balance
P478volume226

Reverse relations

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