Different CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutation

scientific article published on June 2007

Different CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutation is …
instance of (P31):
case reportQ2782326
scholarly articleQ13442814

External links are
P356DOI10.1136/JMG.2006.047530
P932PMC publication ID2740887
P698PubMed publication ID17551084
P5875ResearchGate publication ID6285728

P50authorBrigitte Royer-PokoraQ43376295
P2093author name stringJaume Mora
Carmen de Torres
Noelia Perez
Constanze Uschkereit
Maike Küff
P2860cites workWT-1 is required for early kidney developmentQ28512266
Frequent association of beta-catenin and WT1 mutations in Wilms tumors.Q33927092
A clinical overview of WT1 gene mutationsQ34738955
CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumorsQ35103587
Correlation between a specific Wilms tumour suppressor gene (WT1) mutation and the histological findings in Wilms tumour (WT).Q35559794
A WT1 exon 1 mutation in a child diagnosed with Denys-Drash syndromeQ35926983
Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histologyQ36108223
Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumorQ44143077
Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathwayQ48013596
Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumorsQ57413414
Twenty-four new cases of WT1 germline mutations and review of the literature: genotype/phenotype correlations for Wilms tumor developmentQ80103785
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
P304page(s)393-396
P577publication date2007-06-01
P1433published inJournal of Medical GeneticsQ14640281
P1476titleDifferent CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutation
P478volume44

Reverse relations

described by source (P1343)
Q107117461Wilms1-2l
Q107117463Wilms1-2r

cites work (P2860)
Q37256912An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.
Q38675275Bilateral Wilms tumour: a review of clinical and molecular features
Q51739895Chemotherapy and terminal skeletal muscle differentiation in WT1-mutant Wilms tumors.
Q47670734Clinical relevance of mutations in the Wilms tumor suppressor 1 gene WT1 and the cadherin-associated protein beta1 gene CTNNB1 for patients with Wilms tumors: results of long-term surveillance of 71 patients from International Society of Pediatric O
Q36200428Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study
Q36026373Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15.
Q37998422Genetics of pediatric renal tumors
Q26829595Is Wilms tumor a candidate neoplasia for treatment with WNT/β-catenin pathway modulators?--A report from the renal tumors biology-driven drug development workshop
Q37940867WT1 in disease: shifting the epithelial-mesenchymal balance.
Q92757147Wilm's tumor 1 promotes memory flexibility
Q39747265Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm
Q37866140Wilms tumor--a renal stem cell malignancy?

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