Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis

scientific article

Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.16.10.5386
P932PMC publication ID231537
P698PubMed publication ID8816450
P5875ResearchGate publication ID14389744

P2093author name stringC M Apfel
P Lardelli
F P Lamour
P2860cites workIdentification of a retinoic acid responsive element in the retinoic acid receptor beta geneQ24300919
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RARQ24306431
A human retinoic acid receptor which belongs to the family of nuclear receptorsQ24339631
Identification of a second human retinoic acid receptorQ24339647
Murine isoforms of retinoic acid receptor gamma with specific patterns of expressionQ24558724
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acidsQ24563907
A third human retinoic acid receptor, hRAR-gammaQ24611159
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acidQ27729334
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alphaQ27730245
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genesQ27860623
9-cis retinoic acid is a high affinity ligand for the retinoid X receptorQ28119031
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficientlyQ28208673
Nuclear receptor that identifies a novel retinoic acid response pathwayQ28238002
Identification of a receptor for the morphogen retinoic acidQ28280559
A new retinoic acid receptor identified from a hepatocellular carcinomaQ28280949
A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effectsQ28326620
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRαQ28343032
Characterization of three RXR genes that mediate the action of 9-cis retinoic acidQ28343068
Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mappingQ28378417
Function of retinoic acid receptor gamma in the mouseQ28507388
Function of the retinoic acid receptors (RARs) during development: (I) Craniofacial and skeletal abnormalities in RAR double mutantsQ28512381
A versatile in vivo and in vitro eukaryotic expression vector for protein engineeringQ29620181
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acidQ33332716
The N-terminal portion of domain E of retinoic acid receptors alpha and beta is essential for the recognition of retinoic acid and various analogsQ34541359
Retinoic acid receptorsQ35237147
Modulation of gene function by retinoic acidQ35274564
Identification of a novel retinoic acid receptor in regenerative tissues of the newtQ35530107
Hyperplasia and tumours in lung, breast and other tissues in mice carrying a RAR beta 4-like transgene.Q37638980
Arginine 132 of cellular retinoic acid-binding protein (type II) is important for binding of retinoic acidQ38297900
Improved method for PCR-mediated site-directed mutagenesisQ40226530
Mutagenesis of the Ligand Binding Domain of the Human Retinoic Acid Receptor α Identifies Critical Residues for 9-cis-Retinoic Acid BindingQ41302202
Phytanic acid is a retinoid X receptor ligandQ42556745
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skinQ43632385
Identification of retinoids with nuclear receptor subtype-selective activitiesQ46435681
Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryosQ48684931
Function of the retinoic acid receptors (RARs) during development: (II) Multiple abnormalities at various stages of organogenesis in RAR double mutantsQ52214152
Spontaneous differentiation of trophoblast cells along the spongiotrophoblast cell pathway: expression of members of the placental prolactin gene family and modulation by retinoic acid.Q52216812
Structural determinants of the ligand-binding site of the human retinoic acid receptor alpha.Q52538819
Gamma-interferon, retinoic acid, and cytosine arabinoside induce neuroblastoma differentiation by different mechanismsQ67781605
Retinoic acid induces NGF-dependent survival response and high-affinity NGF receptors in immature chick sympathetic neuronsQ68260375
Enhancement of HL-60 differentiation by a new class of retinoids with selective activity on retinoid X receptorQ70808896
Alteration in the retinoid specificity of retinoic acid receptor-beta by site-directed mutagenesis of Arg269 and Lys220Q71942161
Arg269 and Lys220 of retinoic acid receptor-beta are important for the binding of retinoic acidQ72068800
Purification and functional characterization of the ligand-binding domain from the retinoic acid receptor alpha: evidence that sulfhydryl groups are involved in ligand-receptor interactionsQ72609572
Retinoic acid selectively promotes the survival and proliferation of neurogenic precursors in cultured neural crest cell populationsQ72737899
P4510describes a project that usessite-directed mutagenesisQ2642668
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecttretinoinQ29417
ligand bindingQ61659151
P304page(s)5386-5392
P577publication date1996-10-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleAnalysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis
P478volume16

Reverse relations

cites work (P2860)
Q52833166A mutated PML/RARA found in the retinoid maturation resistant NB4 subclone, NB4-R2, blocks RARA and wild-type PML/RARA transcriptional activities.
Q40968314A unique carboxy-terminus truncation mutant of the retinoic acid receptor alpha gene associated with a variant marker chromosome in a retinoic acid resistant HL-60 subline
Q33957795Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA.
Q28291306Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma
Q73248283Differential role of homologous positively charged amino acid residues for ligand binding in retinoic acid receptor alpha compared with retinoic acid receptor beta
Q47683955Distinct modes of interaction of the retinoic acid receptor alpha with natural and synthetic retinoids
Q74232729Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR
Q38305996Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function
Q38344182Mutational Analysis Reveals That All-trans-retinoic acid, 9-cis-Retinoic acid, and Antagonist Interact with Distinct Binding Determinants of RARα
Q41011313RARalpha antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines
Q33688613Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma
Q34002981Retinoids and ovarian cancer
Q54107215Steroid-induced conformational changes at ends of the hormone-binding domain in the rat glucocorticoid receptor are independent of agonist versus antagonist activity.

Search more.