Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids

scientific article

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1993PNAS...90...30A
P356DOI10.1073/PNAS.90.1.30
P3181OpenCitations bibliographic resource ID3602485
P932PMC publication ID45593
P698PubMed publication ID8380496
P5875ResearchGate publication ID14817803

P50authorPierre ChambonQ1388486
P2093author name stringM Saunders
P Kastner
M Rosenberger
M T Bocquel
J Speck
A Lovey
G Allenby
J F Grippo
S Kazmer
P2860cites workA direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RARQ24306431
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elementsQ24318447
A human retinoic acid receptor which belongs to the family of nuclear receptorsQ24339631
Identification of a second human retinoic acid receptorQ24339647
A third human retinoic acid receptor, hRAR-gammaQ24611159
The steroid and thyroid hormone receptor superfamilyQ27861095
9-cis retinoic acid is a high affinity ligand for the retinoid X receptorQ28119031
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficientlyQ28208673
Nuclear receptor that identifies a novel retinoic acid response pathwayQ28238002
Identification of a receptor for the morphogen retinoic acidQ28280559
cis-trans isomers of lycopene and beta-carotene in human serum and tissuesQ28319256
Physiological occurrence, biosynthesis and metabolism of retinoic acid: evidence for roles of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP) in the pathway of retinoic acid homeostasisQ28333732
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRαQ28343032
Characterization of three RXR genes that mediate the action of 9-cis retinoic acidQ28343068
Terminal-group oxidation of retinol by mouse epidermis. Inhibition in vitro and in vivoQ28594480
The human estrogen receptor has two independent nonacidic transcriptional activation functionsQ29617089
A versatile in vivo and in vitro eukaryotic expression vector for protein engineeringQ29620181
A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathwaysQ33233321
The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exonQ33564956
Molecular cloning of cDNA encoding a second cellular retinoic acid-binding proteinQ33744722
H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genesQ33937627
Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cellsQ34294407
Multiplicity generates diversity in the retinoic acid signalling pathwaysQ35236424
Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cellsQ36529284
Nuclear receptors enhance our understanding of transcription regulationQ39324380
Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptorsQ41602857
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acidQ41608901
Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocationQ41617800
6'-substituted naphthalene-2-carboxylic acid analogs, a new class of retinoic acid receptor subtype-specific ligandsQ41664826
Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcriptionQ41714159
Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curvesQ42596115
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skinQ43632385
Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud.Q43981029
All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs.Q48153966
Biosynthesis of 3-dehydroretinol (vitamin A2) from all-trans-retinol (vitamin A1) in human epidermis.Q54353213
Expression of cellular retinoic acid binding protein (CRABP) in Escherichia coli. Characterization and evidence that holo-CRABP is a substrate in retinoic acid metabolism.Q54691893
Identification and spatial distribution of retinoids in the developing chick limb budQ59070114
Identification of 3-dehydroretinol (vitamin A2) in mouse liverQ68431781
The β-carotene-rich alga Dunaliella bardawil as a source of retinol in a rat dietQ68446973
Retinol metabolism in LLC-PK1 Cells. Characterization of retinoic acid synthesis by an established mammalian cell lineQ69620659
Bioavailability of a natural isomer mixture as compared with synthetic all-trans-beta-carotene in rats and chicksQ69667500
Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasmaQ70091231
The effect of dibutyryl cyclic AMP and butyrate on F9 teratocarcinoma cellular retinoic acid-binding protein activityQ70170745
Holocellular retinol binding protein as a substrate for microsomal retinal synthesisQ70211627
Vitamin A in human skin: I. detection and identification of retinoids in normal epidermisQ70404797
VITAMIN A AND REPRODUCTION IN RATSQ76709648
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecttretinoinQ29417
P304page(s)30-4
P577publication date1993-01-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRetinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids
P478volume90

Reverse relations

cites work (P2860)
Q4662030013-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.
Q2462572713-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice
Q376079404-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.
Q336748699-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes
Q445367679-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid X receptor in human osteoblastic cells
Q338668549-cis retinoic acid induces neurorepair in stroke brain
Q543312109-cis retinoic acid inhibits inflammatory responses of adherent monocytes and increases their ability to induce classical monocyte migration.
Q367006279-cis retinoic acid is the ALDH1A1 product that stimulates melanogenesis
Q411410969-cis retinoic acid--a better retinoid for the modulation of differentiation, proliferation and gene expression in human neuroblastoma
Q210923999-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice
Q425010329-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element
Q428153239-cis-retinoic acid is a natural antagonist for the retinoic acid receptor response pathway
Q36573257A conformational switch in nuclear hormone receptors is involved in coupling hormone binding to corepressor release
Q35221911A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests
Q34343049A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding.
Q39715522A novel type of retinoic acid response element in the second intron of the mouse H2Kb gene is activated by the RAR/RXR heterodimer.
Q28730021A regulatory potential of the Xist gene promoter in vole M. rossiaemeridionalis
Q34454414A role for Hsp90 in retinoid receptor signal transduction
Q35508444A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter
Q43175131Absence of natural intracellular retinoids in mouse bone marrow cells and implications for PML-RARA transformation
Q73797274Activation of three distinct RXR/RAR heterodimers induces growth arrest and differentiation of neuroblastoma cells
Q34540006All-trans retinoic acid regulates hepatic bile acid homeostasis
Q42748761All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas
Q36460690All-trans-retinol is a ligand for the retinoic acid receptors
Q71942161Alteration in the retinoid specificity of retinoic acid receptor-beta by site-directed mutagenesis of Arg269 and Lys220
Q28275389An Endogenous Mammalian Retinoid X Receptor Ligand, At Last!
Q34159024An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain
Q28504786An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2
Q38352832Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis
Q38317766Analysis of transcription complexes and effects of ligands by microelectrospray ionization mass spectrometry
Q58340552Animal Models for Retinoid Receptor Research: Implications for Epidermal Homeostasis, Skin Barrier Function, Wound Healing, and Atopic Dermatitis
Q37100396Antagonism between retinoic acid and fibroblast growth factor signaling during limb development
Q40772421Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2).
Q60955213Bexarotene - a novel modulator of AURKA and the primary cilium in -deficient cells
Q57447553CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins
Q40277767CYP4A11 is repressed by retinoic acid in human liver cells
Q26785497Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?
Q38334685Cellular retinaldehyde-binding protein ligand interactions. Gln-210 and Lys-221 are in the retinoid binding pocket
Q39108405Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases
Q28646103Characterization of a negative retinoic acid response element in the murine Oct4 promoter
Q44063838Characterization of a new endogenous vitamin A metabolite
Q24291127Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol
Q36720205Characterization of cDNAs encoding the chick retinoic acid receptor gamma 2 and preferential distribution of retinoic acid receptor gamma transcripts during chick skin development
Q28375233Characterization of retinoic acid receptor-deficient keratinocytes
Q45140499Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies
Q37651088Chemerin regulation and role in host defense
Q44480242Chemical complementation: small-molecule-based genetic selection in yeast
Q44388263Chromatographic analysis of endogenous retinoids in tissues and serum
Q36036235Coexpression of nuclear receptor partners increases their solubility and biological activities.
Q27748926Conformational adaptation of agonists to the human nuclear receptor RAR gamma
Q33869195Contributions of immunohistochemistry and in situ hybridization to the functional analysis of pituitary adenomas
Q34684531Copper-Induced Cytotoxicity and Transcriptional Activation of Stress Genes in Human Liver Carcinoma (HepG(2)) Cells.
Q24685517Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid
Q34513601Cytochemical and molecular biological aspects of the pituitary and pituitary adenomas--cell differentiation and transcription factors
Q36640996DNA methylation, riboswitches, and transcription factor activity: fundamental mechanisms of gene-nutrient interactions involving vitamins
Q43862186Decreased retinoid concentration and retinoid signalling pathways in human atopic dermatitis
Q27680515Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor   Ligand Binding Domain
Q90341909Delineating the role of MITF isoforms in pigmentation and tissue homeostasis
Q31129920Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid
Q39103054Development of a Magnetic Microbead Affinity Selection Screen (MagMASS) Using Mass Spectrometry for Ligands to the Retinoid X Receptor-α.
Q52647826Development of yeast reporter assay for screening specific ligands of retinoic acid and retinoid X receptor subtypes.
Q28378417Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping
Q42270692Differential effects of 9-cis and all-trans retinoic acid on the induction of retinoic acid receptor-beta and cellular retinoic acid-binding protein II in human neuroblastoma cells
Q24563324Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1
Q28569870Differentiation decreased telomerase activity in rat glioblastoma C6 cells and increased sensitivity to IFN-gamma and taxol for apoptosis
Q38309584Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha
Q36643491Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells
Q64076955Dynamic Methylation of an L1 Transduction Family during Reprogramming and Neurodifferentiation
Q38725969Early induction of pyruvate dehydrogenase kinase 4 by retinoic acids in adipocytes
Q28374452Effect of receptor-selective retinoids on growth and differentiation pathways in mouse melanoma cells
Q36885169Effects of dietary retinoids and carotenoids on immune development
Q39673426Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives
Q36290030Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors
Q52209713Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo.
Q47580754Endogenous retinoid X receptor ligands in mouse hematopoietic cells.
Q41431671Endogenous retinoid X receptors can function as hormone receptors in pituitary cells
Q41102542Engineered Cell Lines as a Tool for Monitoring Biological Activity of Hormone Analogs
Q88244199Enhancing human cord blood hematopoietic stem cell engraftment by targeting nuclear hormone receptors
Q64901148Epidermolytic hyperkeratosis: clinical update.
Q40016745Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer
Q39148613Evolutionary Origin of the Interferon-Immune Metabolic Axis: The Sterol-Vitamin D Link
Q28601254Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering
Q36127906Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury
Q49805080Expression and Regulation of Retinoic Acid Receptor Responders in the Human Placenta
Q33690947Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase
Q24315652Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes
Q38295306Expression of human all-trans-retinoic acid receptor beta and its ligand-binding domain in Escherichia coli.
Q77639038Expression of retinoic acid receptor and retinoid X receptor subtypes in rat liver cells: implications for retinoid signalling in parenchymal, endothelial, Kupffer and stellate cells
Q40873838Expression of retinoid receptors during the retinoic acid-induced neuronal differentiation of human embryonal carcinoma cells
Q33612304Further understanding of fat biology: lessons from a fat fly
Q58695542GPRC5A: An Emerging Biomarker in Human Cancer
Q40423512Gene expression and neuroblastoma cell Differentiation in response to retinoic acid: Differential effects of 9-cis and all-trans retinoic acid
Q24812827Gene induction studies and toxicity of chemical mixtures
Q36732712Generation of gut-homing T cells and their localization to the small intestinal mucosa
Q34666841Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes
Q33571508Gut Microbiota Species Can Provoke both Inflammatory and Tolerogenic Immune Responses in Human Dendritic Cells Mediated by Retinoic Acid Receptor Alpha Ligation
Q39262816High glucose-induced proteome alterations in retinal pigmented epithelium cells and its possible relevance to diabetic retinopathy
Q43246579High-throughput hyperdimensional vertebrate phenotyping.
Q39094660Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans
Q41226836Identification and characterization of a versatile retinoid response element (retinoic acid receptor response element-retinoid X receptor response element) in the mouse tissue transglutaminase gene promoter
Q43976795Immunohistochemical detection of the retinoid acid receptors (RXR-alpha, -beta, -gamma) and Farnesoid X-activated receptor (FXR) in the marbled newt along the annual cycle
Q30448581Immunohistochemistry of COUP-TFI: an adjuvant diagnostic tool for the identification of corticotroph microadenomas
Q46968001Immunosuppressive activity of 13-cis-retinoic acid in rats: aspects of pharmacokinetics and pharmacodynamics
Q50788937Improvement in Aqueous Solubility of Retinoic Acid Receptor (RAR) Agonists by Bending the Molecular Structure.
Q44522321In vitro antimalarial activity of retinoids and the influence of selective retinoic acid receptor antagonists
Q40457642Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells
Q35436487Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3
Q38336801Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis
Q34293950Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells
Q36420207Induction of the oxidative catabolism of retinoid acid in MCF-7 cells
Q48102532Induction of type III‐deiodinase activity in astroglial cells by retinoids
Q40751299Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells
Q41442933Inhibition of collagenase gene expression in synovial fibroblasts by all-trans and 9-cis retinoic acid
Q52561234Inhibition of embryonic retinoic acid synthesis by aldehydes of lipid peroxidation and prevention of inhibition by reduced glutathione and glutathione S-transferases.
Q38315600Inhibition of retinoic acid-inducible transcription by COUP-TFI in human salivary gland adenocarcinoma cell line HSG.
Q70934330Inhibitory effects of 9-cis and all-trans retinoic acid on 1,25(OH)2 vitamin D3-induced bone resorption
Q82862892Interactions of 1,25(OH)(2)D (3) and retinoic acid in the regulation of IEC-6 cell alkaline phosphatase activity
Q37424658Investigation of retinoic acid function during embryonic brain development using retinaldehyde-rescued Rdh10 knockout mice
Q42193650Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid
Q46261787Isotretinoin temporally regulates distinct sets of genes in patient skin
Q42158902Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid
Q44769181Lead-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells
Q38319926Ligand binding properties of human cellular retinoic acid binding protein II expressed in E. coli as a glutathione-S-transferase fusion protein.
Q33503634Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta.
Q37167696Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo
Q33957129Ligand-protein interactions in nuclear receptors of hormones.
Q36419839Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development
Q52203626Localization and ontogeny of the orphan receptor OR-1 in the rat brain.
Q36775185Locust retinoid X receptors: 9-Cis-retinoic acid in embryos from a primitive insect
Q36601606Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment
Q50509859Lycopene induces retinoic acid receptor transcriptional activation in mice.
Q34346065Mapping of RXRB to human chromosome 6p21.3.
Q52508876Marked resistance of RAR gamma-deficient mice to the toxic effects of retinoic acid
Q47121122Mechanisms of urodele limb regeneration
Q34388499Mechanoregulation of h2-calponin gene expression and the role of Notch signaling
Q28346064Metabolism and growth inhibition of four retinoids in head and neck squamous normal and malignant cells
Q33587871Metabolism to a response pathway selective retinoid ligand during axial pattern formation
Q28289521Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal [...]
Q52166439Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers.
Q44938889Modifying effects of 1'-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats
Q22010263Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis
Q41302202Mutagenesis of the Ligand Binding Domain of the Human Retinoic Acid Receptor α Identifies Critical Residues for 9-cis-Retinoic Acid Binding
Q37036052Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis
Q38344182Mutational Analysis Reveals That All-trans-retinoic acid, 9-cis-Retinoic acid, and Antagonist Interact with Distinct Binding Determinants of RARα
Q36655870Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor
Q28469020Neofunctionalization in vertebrates: the example of retinoic acid receptors
Q24657556Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells
Q28367742New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid
Q36445376Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation
Q99564962Nuclear receptors in podocyte biology and glomerular disease
Q34057370PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR
Q35046094PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms
Q77636935Partial replacement of dietary casein with soy protein isolate can reduce the severity of retinoid-induced hypertriglyceridemia
Q37111292Pathways of retinoid synthesis in mouse macrophages and bone marrow cells
Q41175743Pediatric drug development: a perspective from the Cancer Therapy Evaluation Program (CTEP) of the National Cancer Institute (NCI).
Q91640552Pharmacological evidence for the role of RAR in axon guidance and embryonic development of a protostome species
Q36104068Photoreaction, phototoxicity, and photocarcinogenicity of retinoids
Q39448301Physical and functional interactions between cellular retinoic acid binding protein II and the retinoic acid-dependent nuclear complex.
Q34314888Physical mapping of the retinoid X receptor B gene in mouse and human
Q28293014Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR
Q38295556Protein phosphatases 1 and 2A regulate the transcriptional and DNA binding activities of retinoic acid receptors
Q39865277QM/MM refinement and analysis of protein bound retinoic acid
Q40672051Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally
Q37695128RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
Q34052386RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo
Q40522417Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells
Q41431329Regulating adipogenesis
Q37248134Regulation of CD8(+) T cell functions by RARgamma.
Q52210841Regulation of Oct-4 gene expression during differentiation of EC cells.
Q34701888Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin
Q39940312Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages
Q33667591Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.
Q30408649Retinoic acid actions through mammalian nuclear receptors
Q42474415Retinoic acid and nitric oxide promote cell proliferation and differentially induce neuronal differentiation in vitro in the cnidarian Renilla koellikeri
Q36234309Retinoic acid disrupts the Golgi apparatus and increases the cytosolic routing of specific protein toxins
Q37349111Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1.
Q52760701Retinoic acid improves nephrotoxic serum-induced glomerulonephritis through activation of podocyte retinoic acid receptor α.
Q51090675Retinoic acid induces apoptosis of human CD34+ hematopoietic progenitor cells: involvement of retinoic acid receptors and retinoid X receptors depends on lineage commitment of the hematopoietic progenitor cells.
Q31114537Retinoic acid induces expression of the interleukin-1beta gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines
Q35393845Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway
Q43879215Retinoic acid is detected at relatively high levels in the CNS of adult rats
Q28289746Retinoic acid is required for the initiation of outgrowth in the chick limb bud
Q36973819Retinoic acid metabolism blocking agents (RAMBAs): a new paradigm in the treatment of hyperkeratotic disorders
Q44645815Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner.
Q39455138Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification
Q34926648Retinoic acid resistance in acute promyelocytic leukemia
Q40819005Retinoic acid signal transduction pathways.
Q42757325Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes
Q47969876Retinoic acid-dependent upregulation of mouse folate receptor-alpha expression in embryonic stem cells, and conservation of alternative splicing patterns.
Q58789337Retinoid X Receptor Antagonists
Q46085849Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D-responsive elements and elicit additive effects with 1,25-dihydroxyvitamin D3.
Q36565160Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression
Q35830442Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
Q38181177Retinoid X receptor ligands: a patent review (2007 - 2013).
Q37702103Retinoid X receptor-selective ligands produce malformations in Xenopus embryos
Q35163176Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis
Q35840016Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells
Q37241518Retinoid isomers differ in the ability to induce release of SMRT corepressor from retinoic acid receptor-alpha
Q91173850Retinoid receptor turnover mediated by sumoylation, ubiquitination and the valosin-containing protein is disrupted in glioblastoma
Q41005226Retinoid receptors and keratinocytes
Q41239344Retinoid receptors in transcriptional regulation
Q41029752Retinoid signaling in vertebrate limb development
Q77367285Retinoid-X receptor signalling in the developing spinal cord
Q40372674Retinoids and mouse embryonic development
Q47804022Retinoids and related signals in early development of the vertebrate central nervous system.
Q40843728Retinoids induce apoptosis in cultured keratinocytes
Q33676667Retinoids: present role and future potential
Q27025212Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases
Q36789836Role of retinoic receptors in lung carcinogenesis
Q47762482Role of the conserved C-terminal region of thyroid hormone receptor-alpha in ligand-dependent transcriptional activation
Q35053227Selective retinoids and rexinoids in cancer therapy and chemoprevention
Q34831905Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryos
Q52523787Specific teratogenic effects of different retinoic acid isomers and analogs in the developing anterior central nervous system of zebrafish.
Q27677461Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα
Q35217707Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor
Q37267329Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7).
Q55479877Study of O-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid.
Q38694206Sub-micromolar concentrations of retinoic acid induce morphological and functional neuronal phenotypes in SK-N-SH neuroblastoma cells
Q36556052Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific
Q43263400Synthetic retinoids: structure-activity relationships
Q24630638Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action
Q24321948The Retinoic Acid Receptor-alpha mediates human T-cell activation and Th2 cytokine and chemokine production
Q36681083The Role of Isotretinoin Therapy for Cushing's Disease: Results of a Prospective Study
Q57089306The Role of Retinoic Acid in Limb Development
Q50317574The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation.
Q38106981The association of retinoic acid receptor beta2(RARβ2) methylation status and prostate cancer risk: a systematic review and meta-analysis
Q24320338The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
Q40839068The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer
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