The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

scientific article

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/J.1460-2075.1993.TB06196.X
P932PMC publication ID413763
P698PubMed publication ID8262045

P2093author name stringChambon P
Gronemeyer H
Chen Z
White J
Chen JY
Mader S
P2860cites workA direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RARQ24306431
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elementsQ24318447
RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptorsQ24555693
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signalingQ24563064
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acidsQ24563907
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNAQ27651364
9-cis retinoic acid is a high affinity ligand for the retinoid X receptorQ28119031
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficientlyQ28208673
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signallingQ28208726
Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver proteinQ28212739
Solution structure of the DNA-binding domain of the oestrogen receptorQ28263533
All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs.Q48153966
Developmental biology. Reading the retinoid signals.Q52241034
Protein-protein contacts in the glucocorticoid receptor homodimer influence its DNA binding propertiesQ57607831
Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive elementQ59070120
Two nuclear signalling pathways for vitamin DQ59098586
Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimersQ67488391
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimerQ67927526
Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formationQ67927534
Thyroid hormone receptor dimerization function maps to a conserved subregion of the ligand binding domainQ67984001
Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptorQ69208244
Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomersQ28276809
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptorsQ28297907
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptorsQ28326688
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRαQ28343032
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptorsQ29615768
Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptorsQ31159950
H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genesQ33937627
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptorsQ34234016
A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 geneQ34321529
Multiplicity generates diversity in the retinoic acid signalling pathwaysQ35236424
Retinoid receptors in vertebrate limb developmentQ35260064
Retinoids and their receptors in differentiation, embryogenesis, and neoplasiaQ36448344
Transcription activation by estrogen and progesterone receptorsQ36468309
Retinoids, homeoboxes, and growth factors: Toward molecular models for limb developmentQ36506314
Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptorQ36735798
Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptorsQ38322521
Binding characteristics of the thyroid hormone receptor homo- and heterodimers to consensus AGGTCA repeat motifsQ38327954
The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase geneQ38330731
A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoterQ38334173
Multiple cell type-specific proteins differentially regulate target sequence recognition by the alpha retinoic acid receptorQ38338308
Protein-protein interactions facilitate DNA binding by the glucocorticoid receptor DNA-binding domainQ38339682
Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptorQ38341530
Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimerQ38343050
Nuclear receptors enhance our understanding of transcription regulationQ39324380
Defining a minimal estrogen receptor DNA binding domainQ40405712
The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific.Q40448463
A 22-amino-acid peptide restores DNA-binding activity to dimerization-defective mutants of the estrogen receptorQ40640074
Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.Q40872478
Functional characterization of a natural retinoic acid responsive elementQ41083429
Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptorsQ41601861
Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptorsQ41602857
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acidQ41608901
Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylationQ41612337
Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimersQ41639104
Heterodimeric receptor complexes determine 3,5,3'-triiodothyronine and retinoid signaling specificitiesQ43753385
An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cellsQ44741237
High affinity and specificity of dimeric binding of thyroid hormone receptors to DNA and their ligand-dependent dissociationQ45214892
Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activityQ45217737
Solution structure of the glucocorticoid receptor DNA-binding domainQ45817037
Retinoic acid and thyroid hormone induce gene expression through a common responsive element.Q46001994
Determinants of target gene specificity for steroid/thyroid hormone receptorsQ46051437
Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptorsQ46289969
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)5029-5041
P577publication date1993-12-01
P1433published inThe EMBO JournalQ1278554
P1476titleThe patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains
P478volume12

Reverse relations

cites work (P2860)
Q404680569-cis retinoic acid signaling: changing partners causes some excitement
Q40793054A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.
Q38301770A functional glucocorticoid-responsive unit composed of two overlapping inactive receptor-binding sites: evidence for formation of a receptor tetramer
Q24609094A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
Q39715522A novel type of retinoic acid response element in the second intron of the mouse H2Kb gene is activated by the RAR/RXR heterodimer.
Q36553456A retinoic acid response element that overlaps an estrogen response element mediates multihormonal sensitivity in transcriptional activation of the lactoferrin gene
Q37638476Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity
Q24311404Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta
Q37233353All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor
Q33957795Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA.
Q24310501An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
Q38354733Characterization of a dominant negative mutant form of the HNF-4 orphan receptor
Q40322576Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.
Q42152410Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
Q64913381Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity.
Q52671633Conservation of DNA and ligand binding properties of retinoid X receptor from the placozoan Trichoplax adhaerens to human.
Q35725003DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified
Q38305506Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer
Q24563324Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1
Q37630259Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements
Q40726582Dimerization of v-erbA on inverted repeats
Q48088353Direct regulation of vHnf1 by retinoic acid signaling and MAF-related factors in the neural tube
Q36560247Direct repeats bind the EcR/USP receptor and mediate ecdysteroid responses in Drosophila melanogaster
Q33871117Dual FRET assay for detecting receptor protein interaction with DNA.
Q41431671Endogenous retinoid X receptors can function as hormone receptors in pituitary cells
Q40016745Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer
Q77639038Expression of retinoic acid receptor and retinoid X receptor subtypes in rat liver cells: implications for retinoid signalling in parenchymal, endothelial, Kupffer and stellate cells
Q37689018From carrot to clinic: an overview of the retinoic acid signaling pathway
Q36637419Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells
Q33693856Hif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist
Q38356179Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway
Q36775185Locust retinoid X receptors: 9-Cis-retinoic acid in embryos from a primitive insect
Q33587871Metabolism to a response pathway selective retinoid ligand during axial pattern formation
Q41526912Modified steroid receptors and steroid-inducible promoters as genetic switches for gene therapy
Q36549658Natural vitamin D3 response elements formed by inverted palindromes: polarity-directed ligand sensitivity of vitamin D3 receptor-retinoid X receptor heterodimer-mediated transactivation.
Q28367742New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid
Q61818611Nuclear receptor superfamily: Principles of signaling
Q34282476Nuclear-receptor interactions on DNA-response elements
Q40732567PAV-1, a new rat hepatic stellate cell line converts retinol into retinoic acid, a process altered by ethanol.
Q28203481Promoter of FGF8 reveals a unique regulation by unliganded RARalpha
Q37695128RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
Q41844763Rational design of an estrogen receptor mutant with altered DNA-binding specificity
Q37248134Regulation of CD8(+) T cell functions by RARgamma.
Q33803303Regulation of type 1 iodothyronine deiodinase by LXRα
Q39652773Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells
Q30306797Retinoid X receptor and its partners in the nuclear receptor family
Q35840016Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells
Q40372674Retinoids and mouse embryonic development
Q37311048Retinoids regulate human amniotic tissue-type plasminogen activator gene by a two-step mechanism
Q36139646Separation of retinoid X receptor homo- and heterodimerization functions
Q44312225Sequences required for the transition from monomeric to homodimeric forms of thyroid hormone receptor alpha and v-erbA.
Q41815633Small-molecule hormones: molecular mechanisms of action
Q28369692Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists
Q27638917Structural basis of VDR-DNA interactions on direct repeat response elements
Q37414946Structural basis of androgen receptor binding to selective androgen response elements.
Q27730227Structural determinants of nuclear receptor assembly on DNA direct repeats
Q27760617Structural elements of an orphan nuclear receptor-DNA complex
Q27663271Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element
Q27621610Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1
Q24644790Structure of the heterodimeric ecdysone receptor DNA-binding complex
Q35907842The C6 zinc cluster dictates asymmetric binding by HAP1.
Q36554543The Essential DNA-Binding Protein sap1 of Schizosaccharomyces pombe Contains Two Independent Oligomerization Interfaces That Dictate the Relative Orientation of the DNA-Binding Domain
Q37630287The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.
Q41941029The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα.
Q34763533The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids
Q33886680The promoter context is a decisive factor in establishing selective responsiveness to nuclear class II receptors
Q36561262The receptor-DNA complex determines the retinoid response: a mechanism for the diversification of the ligand signal
Q44319351The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes.
Q34974992The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling
Q82863470The vitamin D(3) receptor in the context of the nuclear receptor superfamily : The central role of the retinoid X receptor
Q35814179Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism
Q36053034Transcriptional activities of retinoic acid receptors
Q37411882Understanding nuclear receptor form and function using structural biology
Q80416865V-erba homodimers mediate the potent dominant negative activity of v-erba on everted repeats
Q34926608Variations on a theme: the alternate translocations in APL.
Q40018060Vitamin D interferes with transactivation of the growth hormone gene by thyroid hormone and retinoic acid
Q40393070Vitamin D receptor contains multiple dimerization interfaces that are functionally different
Q52552156Vitamin D receptor interactions with the murine osteopontin response element.
Q35802827Vitamin D receptor-DNA interactions
Q41449208Vitamin D3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation
Q36555582Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors.
Q33269869Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution
Q36931713Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective

Search more.