Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements

scientific article published on March 1994

Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID394959
P698PubMed publication ID8137825

P2093author name stringChambon P
Gronemeyer H
Zechel C
Shen XQ
P2860cites workRXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elementsQ24318447
RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptorsQ24555693
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signalingQ24563064
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNAQ27651364
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elementsQ27731441
The steroid and thyroid hormone receptor superfamilyQ27861095
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficientlyQ28208673
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signallingQ28208726
Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elementsQ28211214
Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver proteinQ28212739
Solution structure of the DNA-binding domain of the oestrogen receptorQ28263533
Protein-protein contacts in the glucocorticoid receptor homodimer influence its DNA binding propertiesQ57607831
Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive elementQ59070120
Two nuclear signalling pathways for vitamin DQ59098586
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimerQ67927526
Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formationQ67927534
DNA Binding Properties of the Vitamin D3Receptor Zinc Finger RegionQ68274304
Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptorQ69208244
An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: evidence of a direct role for retinoids in lens developmentQ70567677
Protein-protein interactions between the DNA-binding domains of nuclear receptors: influence on DNA-bindingQ70730977
The c-erb-A protein is a high-affinity receptor for thyroid hormoneQ28282719
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptorsQ28297907
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptorsQ28326688
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptorsQ29615768
Gene regulation by steroid hormonesQ29618291
Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptorsQ31159950
Evolution of the nuclear receptor gene superfamilyQ33937509
H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genesQ33937627
RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivoQ34052386
The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.Q34064607
Multiplicity generates diversity in the retinoic acid signalling pathwaysQ35236424
Retinoid receptors in vertebrate limb developmentQ35260064
Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptorsQ36290030
Retinoids and their receptors in differentiation, embryogenesis, and neoplasiaQ36448344
Transcription activation by estrogen and progesterone receptorsQ36468309
Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activationQ37066332
The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.Q37630287
The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers.Q38312085
Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA bindingQ38319122
PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene.Q38320134
Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptorsQ38322521
Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptorsQ38329494
A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoterQ38334173
Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptorQ38341530
Nuclear receptors enhance our understanding of transcription regulationQ39324380
Defining a minimal estrogen receptor DNA binding domainQ40405712
Site-specific mutagenesis using asymmetric polymerase chain reaction and a single mutant primerQ40527637
The molecular and genetic dissection of the retinoid signalling pathwayQ40798560
Mechanisms of transactivation by retinoic acid receptorsQ40856444
The N-terminal DNA-binding 'zinc finger' of the oestrogen and glucocorticoid receptors determines target gene specificityQ41092852
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acidQ41608901
Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylationQ41612337
The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formationQ42508346
Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acidsQ43460186
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skinQ43632385
Solution structure of the glucocorticoid receptor DNA-binding domainQ45817037
Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.Q46039694
Determinants of target gene specificity for steroid/thyroid hormone receptorsQ46051437
Determinants for selective RAR and TR recognition of direct repeat HREs.Q46177795
DNA recognition by the oestrogen receptor: from solution to the crystalQ47964761
All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs.Q48153966
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1414-1424
P577publication date1994-03-01
P1433published inThe EMBO JournalQ1278554
P1476titleDimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements
P478volume13

Reverse relations

cites work (P2860)
Q24308781A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity
Q34343049A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding.
Q33887513A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers
Q39447809A novel role for helix 12 of retinoid X receptor in regulating repression
Q41015780A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone
Q24544646Binding of type II nuclear receptors and estrogen receptor to full and half-site estrogen response elements in vitro
Q24554585Characterization of the DNA-binding and dimerization properties of the nuclear orphan receptor germ cell nuclear factor
Q33584820Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals
Q64913381Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity.
Q40393284DNA bending by thyroid hormone receptor: influence of half-site spacing and RXR.
Q34631474Deregulated transcription factors in leukemia
Q36550845Determinants of target gene specificity for ROR alpha 1: monomeric DNA binding by an orphan nuclear receptor
Q24563324Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1
Q36560247Direct repeats bind the EcR/USP receptor and mediate ecdysteroid responses in Drosophila melanogaster
Q37201722Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).
Q40016745Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer
Q37689018From carrot to clinic: an overview of the retinoic acid signaling pathway
Q36797684General molecular biology and architecture of nuclear receptors
Q36549937Genetic dissection of thyroid hormone receptor beta: identification of mutations that separate hormone binding and transcriptional activation
Q33693856Hif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist
Q41045818Human nuclear receptor heterodimers: opportunities for detecting targets of transcriptional regulation using yeast.
Q36061886Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors
Q39634704Mechanism of high-mobility group protein B enhancement of progesterone receptor sequence-specific DNA binding.
Q27852289Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O 3) in acute promyelocytic leukemia
Q77355947Microsecond time scale dynamics in the RXR DNA-binding domain from a combination of spin-echo and off-resonance rotating frame relaxation measurements
Q28367742New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid
Q38922128Nuclear retinoid receptors and pregnancy: placental transfer, functions, and pharmacological aspects
Q39643895Promoter context determines the role of proteasome in ligand-dependent occupancy of retinoic acid responsive elements
Q36876232Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models.
Q37695128RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
Q33882753Regulation of cytochrome P450 (CYP) genes by nuclear receptors.
Q30408649Retinoic acid actions through mammalian nuclear receptors
Q33915545Retinoid X receptor alpha forms tetramers in solution
Q38961328Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings
Q36139646Separation of retinoid X receptor homo- and heterodimerization functions
Q27638917Structural basis of VDR-DNA interactions on direct repeat response elements
Q37414946Structural basis of androgen receptor binding to selective androgen response elements.
Q28115652Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA
Q24644790Structure of the heterodimeric ecdysone receptor DNA-binding complex
Q24652983Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements
Q28509358The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
Q34619185The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron gene expression via multiple mechanisms in Caenorhabditis elegans
Q36554302The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat
Q24815982The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction.
Q33886680The promoter context is a decisive factor in establishing selective responsiveness to nuclear class II receptors
Q82863470The vitamin D(3) receptor in the context of the nuclear receptor superfamily : The central role of the retinoid X receptor
Q34294723Transcription factors as drug targets: opportunities for therapeutic selectivity.
Q37411882Understanding nuclear receptor form and function using structural biology
Q36920549Vitamin A and retinoid signaling: genomic and nongenomic effects
Q40393070Vitamin D receptor contains multiple dimerization interfaces that are functionally different
Q36555582Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors.
Q36931713Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective
Q24561965Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development

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