Translocation of the RAR alpha locus to the PML or PLZF gene in acute promyelocytic leukaemia

scientific article published on March 1994

Translocation of the RAR alpha locus to the PML or PLZF gene in acute promyelocytic leukaemia is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1111/J.1365-2141.1994.TB04773.X
P698PubMed publication ID8043428

P2093author name stringA Zelent
P2860cites workFusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemiaQ24293329
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemiasQ24294368
Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming geneQ24298289
Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifsQ24309063
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elementsQ24318447
COUP transcription factor is a member of the steroid receptor superfamilyQ24339525
A human retinoic acid receptor which belongs to the family of nuclear receptorsQ24339631
Identification of a second human retinoic acid receptorQ24339647
Murine isoforms of retinoic acid receptor gamma with specific patterns of expressionQ24558724
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemiasQ24559974
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signalingQ24563064
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acidsQ24563907
Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha)Q24595994
Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryoQ24600126
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNAQ24606378
A third human retinoic acid receptor, hRAR-gammaQ24611159
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set geneQ24629998
Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitroQ24675695
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteinsQ27861094
The steroid and thyroid hormone receptor superfamilyQ27861095
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PMLQ28118823
9-cis retinoic acid is a high affinity ligand for the retinoid X receptorQ28119031
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 geneQ28201279
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficientlyQ28208673
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signallingQ28208726
Nuclear receptor that identifies a novel retinoic acid response pathwayQ28238002
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locusQ28241824
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALLQ28254962
Activators and targetsQ37856107
Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracleQ38320557
The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineageQ38322297
Retinoids and vertebrate limb pattern formationQ38727722
Nuclear receptors enhance our understanding of transcription regulationQ39324380
Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cellsQ40282939
Continuous growth and differentiation of human myeloid leukaemic cells in suspension cultureQ40512568
A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell lineQ41592567
Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptorsQ41602857
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acidQ41608901
Expression of retinoic acid receptor mRNA in hematopoietic cellsQ41752749
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemiasQ42220357
Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skinQ43632385
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemiasQ44069634
Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonistQ44537287
Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor.Q45959402
Developmental biology. Reading the retinoid signals.Q52241034
Promiscuous liaisonsQ59081808
Two nuclear signalling pathways for vitamin DQ59098586
Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17Q28255789
Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemiaQ28263998
A novel cysteine-rich sequence motifQ28264720
Identification of a receptor for the morphogen retinoic acidQ28280559
A new retinoic acid receptor identified from a hepatocellular carcinomaQ28280949
The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RARQ28300893
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptorsQ28326688
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRαQ28343032
Characterization of three RXR genes that mediate the action of 9-cis retinoic acidQ28343068
The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentationQ28505421
RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codonQ28505823
How eukaryotic transcriptional activators workQ29618289
Gene regulation by steroid hormonesQ29618291
Characterization of a Fusion cDNA (RARA/myl) Transcribed from the t(15;17) Translocation Breakpoint in Acute Promyelocytic LeukemiaQ31159920
Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptorsQ31159950
Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic LeukemiaQ33268330
Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locusQ33334769
Acute promyelocytic leukemia. M.D. Anderson Hospital experienceQ33452068
Development of a highly efficient expression cDNA cloning system: application to oncogene isolationQ33595726
A novel zinc finger coiled-coil domain in a family of nuclear proteinsQ34256632
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factorQ34997317
v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA.Q35000459
Multiplicity generates diversity in the retinoic acid signalling pathwaysQ35236424
Transcriptional regulation by the nuclear receptor superfamilyQ35305477
Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor geneQ36116474
Vitamin A Status: Relationship to Immunity and the Antibody ResponseQ36252277
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acidQ36390529
9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte developmentQ36397870
Retinoids and their targets in vertebrate developmentQ36468786
Retinoids, homeoboxes, and growth factors: Toward molecular models for limb developmentQ36506314
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).Q36708494
Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemiaQ36916496
Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemiaQ37031781
Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response elementQ37619937
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)451-460
P577publication date1994-03-01
P1433published inBritish Journal of HaematologyQ4970200
P1476titleTranslocation of the RAR alpha locus to the PML or PLZF gene in acute promyelocytic leukaemia
P478volume86

Reverse relations

cites work (P2860)
Q34579930A 7-base-pair sequence protects DNA from exonucleolytic degradation in Lactococcus lactis.
Q47821155Acute promyelocytic leukemia as a model for cross-talk between interferon and retinoic acid pathways: from molecular biology to clinical applications.
Q41735639Acute promyelocytic leukemia: cellular and molecular basis of differentiation and apoptosis
Q24308811Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein
Q34310859Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710.
Q34725003Epigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma
Q52264002Expression of leukemia/lymphoma related factor (LRF/Pokemon) in human benign prostate hyperplasia and prostate cancer.
Q34580344Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain
Q45250335Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid
Q41590851Life-and-death decisions influenced by retinoids
Q34244416Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.
Q41043448Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia
Q36552091The BTB domain of bric à brac mediates dimerization in vitro
Q71010044Unbalanced translocation t(5;17) in an atypical acute promyelocytic leukemia
Q41119802Variant and masked translocations in acute promyelocytic leukemia.

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