Clinical trials in ulcerative colitis: a historical perspective

scientific article published on 25 April 2015

Clinical trials in ulcerative colitis: a historical perspective is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1093/ECCO-JCC/JJV074
P698PubMed publication ID25913641
P5875ResearchGate publication ID275525953

P50authorLaurent Peyrin-BirouletQ30248039
Fernando MagroQ37840060
Ailsa HartQ92024668
P2093author name stringAlessandro Armuzzi
Pieter Hindryckx
Filip Baert
Clinical Trial Committee Clincom of the European Crohn’s and Colitis Organisation (ECCO)
P2860cites workInfliximab for induction and maintenance therapy for ulcerative colitisQ28285876
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Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidanceQ29615569
Cyclosporine in severe ulcerative colitis refractory to steroid therapyQ34060783
Adalimumab induces and maintains mucosal healing in patients with Crohn's disease: data from the EXTEND trialQ34156631
Vedolizumab as induction and maintenance therapy for ulcerative colitisQ34365566
Microscopic activity in ulcerative colitis: what does it mean?Q34393414
A systematic review of the measurement of endoscopic healing in ulcerative colitis clinical trials: recommendations and implications for future researchQ35169255
Systematic review: histological remission in inflammatory bowel disease. Is 'complete' remission the new treatment paradigm? An IOIBD initiativeQ35286226
Infliximab in moderately severe glucocorticoid resistant ulcerative colitis: a randomised controlled trial.Q35595821
A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitisQ35768942
Randomised controlled trial of azathioprine withdrawal in ulcerative colitisQ35822294
Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort studyQ36328183
A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitisQ36720357
A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitisQ36720362
Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel diseaseQ37937180
Ulcerative colitis as a progressive disease: the forgotten evidenceQ37967664
Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: special situationsQ38049779
Deep remission in inflammatory bowel disease: looking beyond symptomsQ38077111
The role of centralized reading of endoscopy in a randomized controlled trial of mesalamine for ulcerative colitisQ38092984
Histologic remission: the ultimate therapeutic goal in ulcerative colitis?Q38126285
Patient-reported outcomes as primary end points in clinical trials of inflammatory bowel diseaseQ38188738
Mucosal healing as a target of therapy for colonic inflammatory bowel disease and methods to score disease activityQ38224249
Converging goals of treatment of inflammatory bowel disease from clinical trials and practiceQ38240237
An experiment to determine the active therapeutic moiety of sulphasalazineQ39458926
Ulcerative colitis: definition, historical background, aetiology, diagnosis, naturel history and local complicationsQ40348424
Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditionsQ41067146
An assessment of prednisone, salazopyrin, and topical hydrocortisone hemisuccinate used as out-patient treatment for ulcerative colitisQ43250765
A double blind controlled trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitisQ43250874
Delayed-release oral mesalamine 4.8 g/day (800-mg tablet) is effective for patients with moderately active ulcerative colitisQ43274153
Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitisQ43582796
Methotrexate in ulcerative colitis: a Spanish multicentric study on clinical use and efficacyQ43817874
Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.Q44755672
Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn's diseaseQ45181649
Deep remission in Crohn's disease: is it the end of the placebo effect?Q45927341
Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitisQ46184125
Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitisQ46286038
Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitisQ46990369
Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trialQ49167560
Comparing histological activity indexes in UC.Q51051300
Thiopurines and risk of colorectal neoplasia in patients with inflammatory bowel disease: a meta-analysis.Q53088825
Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial.Q53122367
Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study.Q54007642
Azathioprine in ulcerative colitis: final report on controlled therapeutic trial.Q55266577
Cortisone and corticotrophin in ulcerative colitis.Q55480299
Cortisone in ulcerative colitis; final report on a therapeutic trial.Q55499879
Infliximab, azathioprine, or combination therapy for Crohn's diseaseQ56988763
Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's DiseaseQ57265459
Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis1 1Gert Van Assche, Severine Vermeire, Geert D’Haens, and Paul Rutgeerts have been instrumental in the design of the study, trial manQ57265461
Drug-induced Immunological ToleranceQ59059733
Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trialQ59120396
P433issue7
P921main subjectulcerative colitisQ1477
P304page(s)580-588
P577publication date2015-04-25
P1433published inJournal of Crohn's and ColitisQ15817379
P1476titleClinical trials in ulcerative colitis: a historical perspective
P478volume9

Reverse relations

cites work (P2860)
Q55284143Andrographolide presents therapeutic effect on ulcerative colitis through the inhibition of IL-23/IL-17 axis.
Q49835637Costs of dose escalation among ulcerative colitis patients treated with adalimumab in Germany
Q39098635Defining endoscopic response and remission in ulcerative colitis clinical trials: an international consensus.
Q98894296Development of a Software for Treat-To-Target Strategy Implementation and Increasing Quality of Life in Patients with Inflammatory Bowel Disease
Q38977432Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis
Q40657731Implications of Infliximab Treatment Failure and Influence of Personalized Treatment on Patient-reported Health-related Quality of Life and Productivity Outcomes in Crohn's Disease.
Q38943959Interpreting Registrational Clinical Trials of Biological Therapies in Adults with Inflammatory Bowel Diseases
Q40408942Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
Q92414863The Impact of Raising the Bar for Clinical Trials in Ulcerative Colitis
Q48059378The Impact of Therapeutic Antibodies on the Management of Digestive Diseases: History, Current Practice, and Future Directions.
Q50881664Treat to Target in Inflammatory Bowel Disease.

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