Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial.

scientific article

Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0140-6736(12)61084-8
P698PubMed publication ID23063316

P50authorJean-Frédéric ColombelQ30248037
Gert Van AsscheQ37064266
Javier P GisbertQ37829251
Martti FärkkiläQ42383672
Maria EsteveQ43124466
Maria NachuryQ56850575
P2093author name stringDenis Franchimont
Philippe Marteau
Jean-Yves Mary
Franck Carbonnel
Jacques Moreau
Julien Branche
Guillaume Savoye
Yoram Bouhnik
Jacques Cosnes
Jean-Charles Delchier
Elena Ricart
Arnaud Bourreille
Matthieu Allez
David Laharie
Jean-Louis Dupas
Gilles Bommelaer
Xavier Roblin
Frank Zerbib
Benoit Coffin
Marc Lémann
Olivier Dewit
Antonio Lopez-Sanroman
Jerome Filippi
Martine de Vos
Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives
Stephane Nahon
P2860cites workNonparametric Estimation from Incomplete ObservationsQ25938997
Predictive factors of response to cyclosporine in steroid-refractory ulcerative colitisQ33307776
Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters CommitteeQ33523446
European evidence-based Consensus on the management of ulcerative colitis: Current managementQ34025054
Cyclosporine in severe ulcerative colitis refractory to steroid therapyQ34060783
THE COURSE AND PROGNOSIS OF ULCERATIVE COLITIS.Q34478028
Infliximab in moderately severe glucocorticoid resistant ulcerative colitis: a randomised controlled trial.Q35595821
Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitisQ35760789
The Montreal classification of inflammatory bowel disease: controversies, consensus, and implicationsQ36477912
Infliximab for the treatment of ulcerative colitis: outcomes in Oxford from 2000 to 2006.Q36793930
The pattern and outcome of acute severe colitisQ37814560
Power and sample size calculations. A review and computer programQ37879786
Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitisQ43582796
Safety and efficacy of azathioprine in the maintenance of ciclosporin-induced remission of ulcerative colitisQ43734542
Long-term outcome of treatment with intravenous cyclosporin in patients with severe ulcerative colitisQ43798421
Infliximab for refractory ulcerative colitis or indeterminate colitis: an open-label multicentre studyQ44517208
Infliximab efficacy in pediatric ulcerative colitisQ45285885
Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study.Q46531976
A multicenter experience with infliximab for ulcerative colitis: outcomes and predictors of response, optimization, colectomy, and hospitalizationQ46846798
Infliximab in the treatment of severe, steroid-refractory ulcerative colitis: a pilot study.Q54007642
Cortisone in ulcerative colitis; final report on a therapeutic trial.Q55499879
Ulcerative ColitisQ55922642
Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis1 1Gert Van Assche, Severine Vermeire, Geert D’Haens, and Paul Rutgeerts have been instrumental in the design of the study, trial manQ57265461
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized studyQ68206432
Low colectomy rates in ulcerative colitis in an unselected European cohort followed for 10 yearsQ79676507
Infliximab in severe ulcerative colitis: short-term results of different infusion regimens and long-term follow-upQ80793210
European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel diseaseQ82963520
P433issue9857
P407language of work or nameEnglishQ1860
P921main subjectulcerative colitisQ1477
cyclosporineQ367700
P304page(s)1909-1915
P577publication date2012-10-10
P1433published inThe LancetQ939416
P1476titleCiclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial.
P478volume380

Reverse relations

cites work (P2860)
Q906191452019 Expert opinion on biological treatment use in inflammatory bowel disease management
Q38287132A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis.
Q35973766A Saudi Gastroenterology association position statement on the use of tumor necrosis factor-alfa antagonists for the treatment of inflammatory bowel disease
Q34353032A medicoeconomic review of early intervention with biologic agents in the treatment of inflammatory bowel diseases
Q92690822AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis
Q92690717AGA Technical Review on the Management of Moderate to Severe Ulcerative Colitis
Q38204993Ability of different rescue therapies to save the bowel in acute, severe, steroid-refractory ulcerative colitis
Q38942561Acute severe ulcerative colitis: from pathophysiology to clinical management
Q49232336Acute severe ulcerative colitis: latest evidence and therapeutic implications
Q26798299Advances in refractory ulcerative colitis treatment: A new therapeutic target, Annexin A2
Q38130044Advances in the medical management of paediatric IBD.
Q38816194Anti TNF-α therapy for ulcerative colitis: current status and prospects for the future.
Q92226508Azathioprine Is Useful for Maintaining Long-term Remission Induced by Tacrolimus for the Treatment of Ulcerative Colitis: An Inverse Probability of a Treatment Weighing Analysis
Q38961202B Cell-Activating Factor (BAFF)-Targeted B Cell Therapies in Inflammatory Bowel Diseases.
Q38630959Balancing the risks and benefits of biologic therapy in inflammatory bowel diseases.
Q92410206Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn's disease in Asia
Q38568898Biologic agents for IBD: practical insights
Q31017419Biologics in inflammatory bowel disease: what are the data?
Q26999078Biologics in the management of ulcerative colitis - comparative safety and efficacy of TNF-α antagonists
Q90339285British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults
Q38432470CCR9 antagonism: potential in the treatment of Inflammatory Bowel Disease.
Q52346955Chinese research into severe ulcerative colitis has increased in quantity and complexity.
Q52673722Clinical Response and Complications are not Associated with Drug Levels in Patients with Severe Ulcerative Colitis on IV Cyclosporine Induction Therapy.
Q38443024Clinical trials in ulcerative colitis: a historical perspective
Q44641895Commentary: salvage medical therapy for acute severe colitis - ciclosporin or infliximab?
Q89623411Comparable Long-Term Outcomes of Cyclosporine and Infliximab in Patients With Steroid-Refractory Acute Severe Ulcerative Colitis: A Meta-Analysis
Q40425878Comparison of Infliximab and Adalimumab in Biologic-Naive Patients With Ulcerative Colitis: A Nationwide Danish Cohort Study
Q50097248Comparison of Safety and Efficacy of Tacrolimus versus Infliximab for Active Ulcerative Colitis.
Q46201026Comparison of mortality following hospitalisation for ulcerative colitis in Scotland between 1998-2000 and 2007-2009.
Q52626302Contemporary Management of Ulcerative Colitis.
Q89061132Contemporary Medical Management of Acute Severe Ulcerative Colitis
Q38293796Conventional drug therapy for inflammatory bowel disease
Q36815176Cost utility of inflammation-targeted therapy for patients with ulcerative colitis
Q64269853Curcumin and resveratrol suppress dextran sulfate sodium‑induced colitis in mice
Q34809305Current and emerging biologics for ulcerative colitis
Q39098635Defining endoscopic response and remission in ulcerative colitis clinical trials: an international consensus.
Q43139980Does the Cyclosporine Still Have a Potential Role in the Treatment of Acute Severe Steroid-Refractory Ulcerative Colitis?
Q38126004Drug advances in inflammatory bowel disease
Q38365426Early investigational TNF receptor antagonists for the treatment of ulcerative colitis
Q89260034Effect of Accelerated Infliximab Induction on Short- and Long-term Outcomes of Acute Severe Ulcerative Colitis: A Retrospective Multicenter Study and Meta-analysis
Q35777883Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis
Q38662186Efficacy and Safety of Tacrolimus Therapy for Active Ulcerative Colitis; A Systematic Review and Meta-analysis.
Q36637710Efficacy of infliximab in acute severe ulcerative colitis: a single-centre experience
Q26768270Elderly patients and inflammatory bowel disease
Q89540272Essential updates 2018/2019: Colorectal (benign): Recent updates (2018-2019) in the surgical treatment of benign colorectal diseases
Q38258954European evidence based consensus on surgery for ulcerative colitis
Q50079201Evidence-based clinical practice guidelines for inflammatory bowel disease.
Q38724227Examining maintenance care following infliximab salvage therapy for acute severe ulcerative colitis.
Q47849060Exploration of predictive biomarkers of early infliximab response in acute severe colitis: A prospective pilot study
Q36615081First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis-results from a multicenter prospective randomized controlled trial and its post hoc analysis
Q89459590First-Line Biologics or Small Molecules in Inflammatory Bowel Disease: a Practical Guide for the Clinician
Q39085361Gastrointestinal diseases and their oro-dental manifestations: Part 2: Ulcerative colitis
Q26866110Glucose intolerance and diabetes mellitus in ulcerative colitis: pathogenetic and therapeutic implications
Q64062261Has infliximab influenced the course and prognosis of acute severe ulcerative colitis?
Q92025298Head-to-head trials in inflammatory bowel disease: past, present and future
Q38253145How safe is infliximab therapy during pregnancy and lactation in inflammatory bowel disease?
Q48200915Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study
Q38838173Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series
Q38072282IBD in 2012: Pathogenesis and management of IBD--thinking outside the box.
Q56973177IBD. Sequential rescue therapy in steroid-refractory ulcerative colitis
Q40181878Impact of Infliximab and Cyclosporine on the Risk of Colectomy in Hospitalized Patients with Ulcerative Colitis Complicated by Cytomegalovirus-A Multicenter Retrospective Study
Q26771136Impact of thiopurines and anti-tumour necrosis factor therapy on hospitalisation and long-term surgical outcomes in ulcerative colitis
Q40430505Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation
Q39841706Induction infliximab levels among patients with acute severe ulcerative colitis compared with patients with moderately severe ulcerative colitis.
Q53241323Inflammatory Bowel Disease.
Q47961270Inflammatory Bowel Disease: Pathophysiology and Current Therapeutic Approaches
Q38609076Inflammatory bowel disease in the UK: is quality of care improving?
Q90331029Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): Crohn's disease
Q89986502Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): ulcerative colitis
Q27005445Inflammatory pathways of importance for management of inflammatory bowel disease
Q41266366Infliximab Does Not Worsen Outcomes During Flare-ups Associated with Cytomegalovirus Infection in Patients with Ulcerative Colitis
Q46875109Infliximab as rescue therapy in hospitalised patients with steroid-refractory acute ulcerative colitis: a long-term follow-up of 211 Swedish patients.
Q64121962Infliximab in inflammatory bowel disease
Q42381018Infliximab or ciclosporin for acute severe ulcerative colitis?
Q36037115Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study.
Q37196938Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial
Q45947185Infliximab versus ciclosporin in severe ulcerative colitis.
Q38117175Investigational cytokine-targeted therapies for ulcerative colitis.
Q90724329Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota
Q90136814Landmark studies and emerging strategies for the management of acute severe ulcerative colitis
Q43534755Letter: ciclosporin or infliximab in acute ulcerative colitis - still undecided; authors' reply
Q48094924Letter: dose optimising infliximab in acute severe ulcerative colitis - authors' reply.
Q38694769Long-Term Efficacy and Safety of Cyclosporine in a Cohort of Steroid-Refractory Acute Severe Ulcerative Colitis Patients from the ENEIDA Registry (1989-2013): A Nationwide Multicenter Study.
Q61911786Long-Term Follow-Up of Patients Treated with Infliximab for Ulcerative Colitis: Predictive Factors of Response—An Observational Study
Q44478513Long-term increase in serum cholesterol levels in ulcerative colitis patients treated with cyclosporine: an underdiagnosed side effect frequently associated with other drug-related complications.
Q36167512MANAGEMENT OF ACUTE SEVERE ULCERATIVE COLITIS: A CLINICAL UPDATE.
Q38848140Maintenance therapy options for ulcerative colitis.
Q91817020Management of Acute Severe Colitis in the Era of Biologicals and Small Molecules
Q34508900Management of acute severe ulcerative colitis
Q38102982Management of difficult-to-treat patients with ulcerative colitis: focus on adalimumab
Q38321528Management of severe ulcerative colitis
Q33819473Management of ulcerative colitis in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease
Q42116204Managing acute severe ulcerative colitis in the hosptialised setting
Q26777729Medical Therapy of Active Ulcerative Colitis
Q33958740Need for infliximab dose intensification in Crohn's disease and ulcerative colitis
Q38670811New treatment strategies for ulcerative colitis
Q41949151Novel treatment options for ulcerative colitis
Q102049664Optimising management strategies of inflammatory bowel disease in resource-limited settings in Asia
Q26866940Optimization of the treatment with immunosuppressants and biologics in inflammatory bowel disease
Q38687407Optimizing pharmacologic management of inflammatory bowel disease
Q39338382Outcome of inflammatory bowel disease patients treated with TNF-α inhibitors: two-year follow-up
Q30664895Outcomes of rescue therapy in acute severe ulcerative colitis: data from the United Kingdom inflammatory bowel disease audit
Q48161573Pharmacologic therapies for severe steroid refractory hospitalized ulcerative colitis: A network meta-analysis
Q38542903Positioning Therapy for Ulcerative Colitis
Q57167308Positioning of old and new biologicals and small molecules in the treatment of inflammatory bowel diseases
Q90656536Post-induction infliximab trough levels and disease activity in the clinical evolution of pediatric ulcerative colitis
Q38286166Predicting outcomes in acute severe ulcerative colitis
Q37106707Prognostic factors affecting early colectomy in patients with moderate to severe ulcerative colitis treated with calcineurin inhibitors
Q38117907Prolonged preoperative hospital stay is a risk factor for complications after emergency colectomy for severe colitis
Q36249551Protective Effect of Calculus Bovis Sativus on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice
Q43190589Pushing the pedal to the metal: should we accelerate infliximab therapy for patients with severe ulcerative colitis?
Q37054120Qingchang Wenzhong Decoction Ameliorates Dextran Sulphate Sodium-Induced Ulcerative Colitis in Rats by Downregulating the IP10/CXCR3 Axis-Mediated Inflammatory Response
Q28657925Randomised controlled trial. Comparison Of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis: Trial design and protocol (CONSTRUCT)
Q38815035Recent trends and future directions for the medical treatment of ulcerative colitis.
Q92798584Remicade® (infliximab): 20 years of contributions to science and medicine
Q50942285Rescue therapy: ciclosporin or infliximab?
Q34528270Review article: acute severe ulcerative colitis - evidence-based consensus statements.
Q26823221Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis
Q30239077Review article: dose optimisation of infliximab for acute severe ulcerative colitis
Q35883580Review article: the practical management of acute severe ulcerative colitis
Q26992012Review article: the role of anti-TNF in the management of ulcerative colitis -- past, present and future
Q39251794Reviewing treatments and outcomes in the evolving landscape of ulcerative colitis
Q38230163Role in calcineurin inhibitors for inflammatory bowel disease in the biologics era: when and how to use.
Q88677985Sarcopenia is a Novel Predictor of the Need for Rescue Therapy in Hospitalized Ulcerative Colitis Patients
Q43611596Short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - experience in 130 patients
Q98386851Simple water-based tacrolimus enemas for refractory proctitis
Q64107563Surgery in the age of biologics
Q38575522Surgical and medical treatment in patients with acute severe ulcerative colitis
Q38726448Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids
Q61821109Systematic Review and Meta-analysis: Optimal Salvage Therapy in Acute Severe Ulcerative Colitis
Q90395393Systematic Review: Efficacy and Safety of Accelerated Induction Regimes in Infliximab Rescue Therapy for Hospitalized Patients with Acute Severe Colitis
Q38404037Systematic Review: Sequential Rescue Therapy in Severe Ulcerative Colitis: Do the Benefits Outweigh the Risks?
Q37044321Systematic review and meta-analysis of third-line salvage therapy with infliximab or cyclosporine in severe ulcerative colitis
Q26997361Tacrolimus for the Treatment of Ulcerative Colitis
Q31004717Tacrolimus or infliximab for severe ulcerative colitis: short-term and long-term data from a retrospective observational study
Q38160905Targeting TNF-α for the treatment of inflammatory bowel disease
Q39037681The biologics of ulcerative colitis
Q60017517The current state of the art for biological therapies and new small molecules in inflammatory bowel disease
Q44033640The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients
Q91645954The efficacy of maintenance therapy after remission induction with tacrolimus in ulcerative colitis with and without previous tumor necrosis factor-α inhibitor
Q38121000The positioning of colectomy in the treatment of ulcerative colitis in the era of biologic therapy
Q38180807Therapeutic peptides in inflammatory bowel disease
Q38778842There is Significant Practice Pattern Variability in the Management of the Hospitalized Ulcerative Colitis Patient at a Tertiary Care and IBD Referral Center.
Q42695266Time to clinical response and remission for therapeutics in inflammatory bowel diseases: What should the clinician expect, what should patients be told?
Q37576428Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial
Q38285619Treatment of IBD: where we are and where we are going
Q64236406Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial
Q41894047Tumor necrosis factor alpha blocking agents as treatment for ulcerative colitis intolerant or refractory to conventional medical therapy: a meta-analysis
Q38258440Tumor necrosis factor-alpha antagonists twenty years later: what do Cochrane reviews tell us?
Q55214747Ulcerative Colitis Endoscopic Index of Severity (UCEIS) versus Mayo Endoscopic Score (MES) in guiding the need for colectomy in patients with acute severe colitis.
Q92443656Ulcerative Colitis: Current and Emerging Treatment Strategies
Q38331566Ulcerative Colitis: What is the Optimal Treatment Goal and How Do We Achieve It?
Q88899916Ulcerative colitis
Q38217653Ulcerative colitis: current pharmacotherapy and future directions.
Q38211425Ulcerative colitis: management in adults, children and young people (NICE Clinical Guideline CG166).
Q47252968Ulcerative colitis: management in adults, children and young people - concise guidance .
Q85643166Ulcerative colitis: steroid-refractory ulcerative colitis-ciclosporin or infliximab?
Q39102244Update on the Use of Biologic Therapy in Ulcerative Colitis
Q40777140Use of Serum Infliximab Level Prior to Cyclosporine Salvage Therapy in Severe Ulcerative Colitis
Q33732010Validation of the Crohn's and Ulcerative Colitis questionnaire in patients with acute severe ulcerative colitis.
Q50629702Vedolizumab: a novel treatment for ipilimumab-induced colitis.
Q50131636Yes, We Are Still Talking about Cylosporin vs. Infliximab in Steroid Resistant Acute Severe Ulcerative Colitis
Q50483940[New advances in the treatment of inflammatory bowel disease].
Q50483943[Safety in the diagnosis and treatment of inflammatory bowel disease].
Q87404464[Therapy of chronic inflammatory bowel diseases. Standards, controversies and perspectives]

Search more.