Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer.

scientific article published on 07 August 2013

Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/IJC.28381
P698PubMed publication ID23852449

P50authorJae Hee CheonQ38639123
P2093author name stringTae Il Kim
Won Ho Kim
Chang Mo Moon
Kyoung Jin Lee
Ji-Hee Kwon
Jae Jun Park
Sung Pil Hong
Sun-Hee Oh
Ji Suk Kim
P2860cites workTruncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2Q24650743
Phenotypic characterization of human colorectal cancer stem cellsQ24674126
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008Q27860674
Stem cells, cancer, and cancer stem cellsQ27860878
Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancerQ28188848
A randomized trial of aspirin to prevent colorectal adenomasQ28195296
Identification of selective inhibitors of cancer stem cells by high-throughput screeningQ28255115
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survivalQ28277824
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiationQ28368349
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)Q28586461
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gammaQ29615221
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomasQ29620630
PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cellsQ30484694
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofenQ31634572
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapyQ33344524
Augmented expression of P-gp/multi-drug resistance gene by all-trans retinoic acid in monocytic leukemic cellsQ34104156
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosisQ34359198
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remissionQ34611836
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.Q34649758
Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030.Q35125616
Role of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatmentQ35148973
The role of COX-2 in intestinal inflammation and colorectal cancerQ35234704
Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibitionQ35415181
Breast cancer stem cells, cytokine networks, and the tumor microenvironmentQ35571904
Cancer immunology--analysis of host and tumor factors for personalized medicineQ35583180
Prostaglandin E2 promotes intestinal tumor growth via DNA methylationQ35742739
Human colon cancer stem cells: a new paradigm in gastrointestinal oncologyQ37186422
Tumour-initiating cells: challenges and opportunities for anticancer drug discoveryQ37606286
Targeting Wnt signaling: can we safely eradicate cancer stem cells?Q37763415
Aspirin as adjuvant therapy for colorectal cancer--reinterpreting paradigmsQ38036541
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancerQ39227342
Symmetric division of cancer stem cells--a key mechanism in tumor growth that should be targeted in future therapeutic approachesQ40219494
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.Q40350197
Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugsQ42551374
The role of NF-κB and PPARγ in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors.Q43049437
Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivoQ43110972
Regulation of Notch1/NICD and Hes1 expressions by GSK-3alpha/betaQ46123301
CD133+CD44+ population efficiently enriches colon cancer initiating cellsQ46457938
The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathwayQ46718510
Sulindac suppresses tumorigenesis in the Min mouse.Q53452327
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.Q54374200
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
neoplastic stem cellsQ1638475
P304page(s)519-529
P577publication date2013-08-07
P1433published inInternational Journal of CancerQ332492
P1476titleNonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer
P478volume134

Reverse relations

cites work (P2860)
Q37687351A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment
Q54939383Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.
Q40160860Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition
Q58796715Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer
Q35833223Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer
Q33727848Aspirin improves outcome in high risk prostate cancer patients treated with radiation therapy
Q40352933Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells
Q46605584Breast Cancer Stem Cell Potent Copper(II)-Non-Steroidal Anti-Inflammatory Drug Complexes
Q64880830Breast cancer stem cells and the challenges of eradication: a review of novel therapies.
Q36608674Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells
Q33688897Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN.
Q27026428Chemopreventive drugs: mechanisms via inhibition of cancer stem cells in colorectal cancer
Q35452772Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer
Q89835973Cytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers
Q38322466Delivery of therapeutics using nanocarriers for targeting cancer cells and cancer stem cells
Q91672650Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches
Q92219419Exploring the Pharmacological Mechanism of the Herb Pair "HuangLian-GanJiang" against Colorectal Cancer Based on Network Pharmacology
Q38914804HES1 promotes metastasis and predicts poor survival in patients with colorectal cancer
Q50510470Indomethacin sensitizes resistant transformed cells to macrophage cytotoxicity.
Q39032753Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis
Q37706766Metabolic enzymes: key modulators of functionality in cancer stem-like cells
Q64059666Molecular iodine exerts antineoplastic effects by diminishing proliferation and invasive potential and activating the immune response in mammary cancer xenografts
Q92889973Notch and breast cancer metastasis: Current knowledge, new sights and targeted therapy
Q38715916POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells
Q58554308PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer
Q36604053Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice
Q89053710R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells
Q88588314Role of prostanoids in gastrointestinal cancer
Q41441045Silencing of HJURP induces dysregulation of cell cycle and ROS metabolism in bladder cancer cells via PPARγ-SIRT1 feedback loop
Q39251611Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway
Q55268769TGF-β1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis.
Q89538015The Association Between Inflammation, Epithelial Mesenchymal Transition and Stemness in Colorectal Carcinoma
Q38759894The Potent Inhibitory Effect of a Naproxen-Appended Cobalt(III)-Cyclam Complex on Cancer Stem Cells
Q36183080The effect of prediagnostic aspirin use on the prognosis of stage III colorectal cancer
Q28087427The evolving role of nonsteroidal anti-inflammatory drugs in colon cancer prevention: a cause for optimism
Q36679858The hallmarks of premalignant conditions: a molecular basis for cancer prevention
Q35790286The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study
Q90040642Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness
Q48588772YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like Cells

Search more.