TTBK2: a tau protein kinase beyond tau phosphorylation

scientific article published on 09 April 2015

TTBK2: a tau protein kinase beyond tau phosphorylation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1155/2015/575170
P932PMC publication ID4407412
P698PubMed publication ID25950000
P5875ResearchGate publication ID276902590

P50authorJung-Chi LiaoQ88778668
P2093author name stringChih-Wei Chang
T Tony Yang
Rueyhung Roc Weng
Ching-Te Kuo
P2860cites workJoubert Syndrome and related disordersQ21202880
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The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesisQ24303418
Centriole distal appendages promote membrane docking, leading to cilia initiationQ24310904
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262Q24313123
The protein kinase complement of the human genomeQ24324497
Cep97 and CP110 suppress a cilia assembly programQ24338361
HEF1-dependent Aurora A activation induces disassembly of the primary ciliumQ24647111
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Tau-tubulin kinaseQ26829288
The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitorQ27682266
X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitorsQ27686685
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Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.Q27919715
TTBK2 kinase: linking primary cilia and cerebellar ataxiasQ28000115
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.Q28000151
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Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classificationQ28131753
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A role for the primary cilium in Notch signaling and epidermal differentiation during skin developmentQ28510710
The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43Q28542476
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When cilia go bad: cilia defects and ciliopathiesQ29547198
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PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblastsQ29614616
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathwaysQ29614619
CiliopathiesQ29614821
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The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.Q30490027
Autosomal dominant cerebellar ataxias: polyglutamine expansions and beyondQ33665814
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Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centrioleQ33925659
Novel TMEM67 mutations and genotype-phenotype correlates in meckelin-related ciliopathiesQ34054602
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary ciliumQ34055484
Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohortQ34094347
Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han ChineseQ34158297
PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell linesQ34226634
Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brainQ34307528
Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the ciliary tip during ciliary assemblyQ34366058
Nephronophthisis-associated ciliopathiesQ34629900
Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau proteinQ34647932
Recent advances in the molecular pathology, cell biology and genetics of ciliopathiesQ34733619
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.Q34913399
EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanismsQ35112285
Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domainsQ35199848
Role of tau protein in both physiological and pathological conditions.Q35715199
Stages of ciliogenesis and regulation of ciliary lengthQ35718497
The many faces of tauQ35870359
Tau protein function in living cellsQ36216609
Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.Q36991962
The role of tau in neurodegenerationQ37145919
Biochemistry of Tau in Alzheimer's disease and related neurological disorders.Q37157831
Tau phosphorylation: the therapeutic challenge for neurodegenerative diseaseQ37402114
Making sense of cilia in disease: the human ciliopathies.Q37624563
Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degenerationQ38019803
Tau protein kinases: involvement in Alzheimer's diseaseQ38022361
Regulation of cilium length and intraflagellar transport.Q38085108
Primary cilia in neurodevelopmental disordersQ38168054
Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesisQ38949635
An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer diseaseQ39135430
Superresolution STED microscopy reveals differential localization in primary ciliaQ39249648
Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.Q40241298
Nephronophthisis (medullary cystic disease of the kidney). A study using electron microscopy, immunofluorescence, and a review of the morphological findings.Q40300634
Structure, microtubule interactions, and phosphorylation of tau proteinQ40983176
An aurora kinase is essential for flagellar disassembly in ChlamydomonasQ42458808
EB1 is required for primary cilia assembly in fibroblastsQ42514941
Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cellsQ42829498
Founder mutations and genotype-phenotype correlations in Meckel-Gruber syndrome and associated ciliopathiesQ43241933
Asator, a tau-tubulin kinase homolog in Drosophila localizes to the mitotic spindleQ43248251
Upregulation of Na+,Cl(-)-coupled betaine/γ-amino-butyric acid transporter BGT1 by Tau tubulin kinase 2.Q46188507
Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2.Q48643854
A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteinsQ48770657
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.Q52200995
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.Q53246695
Identification of proteins expressed differently among surgically resected stage I lung adenocarcinomas.Q54468442
Spinocerebellar ataxia type 11 (SCA11) is an uncommon cause of dominant ataxia among French and German kindreds.Q54659616
The nephronophthisis complex. A clinicopathologic study in childrenQ59281289
The resorption of primary cilia during mitosis in a vertebrate (PtK1) cell lineQ66928001
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectenzymeQ8047
phosphorylationQ242736
nerve tissue proteinQ6996861
cytoskeletal proteinsQ66563066
P304page(s)575170
P577publication date2015-04-09
P1433published inBioMed Research InternationalQ17509958
P1476titleTTBK2: a tau protein kinase beyond tau phosphorylation
P478volume2015

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