Effects of flavonoids genistein and biochanin a on gene expression and their metabolism in human mammary cells

scientific article published on January 2007

Effects of flavonoids genistein and biochanin a on gene expression and their metabolism in human mammary cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/01635580701268196
P698PubMed publication ID17516862
P5875ResearchGate publication ID6315493

P2093author name stringMarilyn E Morris
Daniel A Brazeau
Young Jin Moon
P2860cites workAkt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesQ24534395
HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradationQ24679412
Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonistQ27619550
Regulation of cell death protease caspase-9 by phosphorylationQ28288607
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and betaQ28304508
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens.Q33940621
Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycleQ34095991
Estrogens and cell-cycle regulation in breast cancerQ34336956
Multiple proteases process viral antigens for presentation by MHC class I molecules to CD8(+) T lymphocytesQ34801834
Mechanisms of cancer chemoprevention by soy isoflavone genisteinQ35054157
Phyto-oestrogens and osteoporosis: what is a safe dose?Q35119194
Soy isoflavones and cancer preventionQ35589203
The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.Q40420028
Phytoestrogen exposure elevates PTEN levelsQ40435447
Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylationQ40623346
WT1-p53 interactions in insulin-like growth factor-I receptor gene regulationQ40688483
Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinaseQ40736566
Growth inhibition of human endothelial cells by the phyto-oestrogen biochanin A, a metabolite of genisteinQ40806889
EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicityQ40896750
Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cellsQ40983049
The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A.Q41171594
Factors influencing benzo[a]pyrene metabolism in human mammary epithelial cells in cultureQ41379987
Cyclin E is a target of WT1 transcriptional repressionQ42817131
Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1/2 pathway and serum response elementsQ43596654
Anticarcinogenic effects of isoflavones may be mediated by genistein in mouse mammary tumor virus-induced breast cancerQ43865724
Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapyQ44413850
Effects of the phytoestrogens genistein and daidzein on BRCA2 tumor suppressor gene expression in breast cell linesQ44525729
Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathwayQ44540468
Regulation of uterine hsp90alpha, hsp72 and HSF-1 transcription in B6C3F1 mice by beta-estradiol and bisphenol A: involvement of the estrogen receptor and protein kinase C.Q44555104
Determination of isoflavones in red clover and related species by high-performance liquid chromatography combined with ultraviolet and mass spectrometric detectionQ44644906
Ligand-induced regulation of ERalpha and ERbeta is indicative of human breast cancer cell proliferation.Q44657533
Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrestQ44732887
Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour typesQ48181670
Molecular classification of breast cancer patients by gene expression profiling.Q52052942
P433issue1
P304page(s)48-58
P577publication date2007-01-01
P1433published inNutrition and CancerQ7070508
P1476titleEffects of flavonoids genistein and biochanin a on gene expression and their metabolism in human mammary cells
P478volume57

Reverse relations

cites work (P2860)
Q33567159Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME.
Q33652374Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells
Q43099885Biochanin A induction of sulfotransferases in rats
Q38501205Biochanin A inhibits breast cancer tumor growth in a murine xenograft model
Q37731217DNA Microarray-Based Screening and  Characterization of Traditional Chinese Medicine
Q42503948Dietary genistein stimulates mammary hyperplasia in gilts
Q55043805Natural Products for the Management and Prevention of Breast Cancer.
Q38504206Real-time quantitative polymerase chain reaction for BCRP, MDR1, and MRP1 mRNA levels in lymphocytes and monocytes
Q35888396Role of metabolism in the effects of genistein and its phase II conjugates on the growth of human breast cell lines
Q35226221Structural determinant of chemical reactivity and potential health effects of quinones from natural products
Q35000427The impact of dietary isoflavonoids on malignant brain tumors
Q36676676The preventive effect of biochanin a on bone loss in ovariectomized rats: involvement in regulation of growth and activity of osteoblasts and osteoclasts.

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