The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?

scientific article published on 17 May 2015

The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class? is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2015/806979
P932PMC publication ID4449938
P698PubMed publication ID26075286
P5875ResearchGate publication ID275271635

P50authorRosa FernandesQ47503161
Flávio ReisQ38545312
Cristina MegaQ85378759
Eugénia CarvalhoQ42516249
Edite Teixeira De LemosQ64190488
P2093author name stringFrederico Teixeira
Ricardo Godinho
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The potential risks of pancreatitis and pancreatic cancer with GLP-1-based therapies are far outweighed by the proven and potential (cardiovascular) benefitsQ38145277
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Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat dietQ39599495
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Effect of renal impairment on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor linagliptin(*)Q84358203
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Saxagliptin (Onglyza): new inhibitor of the dipeptidylpeptidase-4 for the oral treatment of type 2 diabetesQ42802918
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Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitusQ42914097
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Hydrophilic residues surrounding the S1 and S2 pockets contribute to dimerisation and catalysis in human dipeptidyl peptidase 8 (DP8).Q43035089
Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trialQ43086322
Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetesQ43087481
Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetesQ43187035
Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetesQ43195702
Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice.Q43224233
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Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemiaQ43275817
Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreasQ43276184
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Efficacy and safety of sitagliptin added to ongoing metformin and pioglitazone combination therapy in a randomized, placebo-controlled, 26-week trial in patients with type 2 diabetesQ43467002
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Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetesQ43972608
GLP-1 based agents and acute pancreatitis : drug safety falls victim to the three monkey paradigmQ44017411
Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axisQ44103908
Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patientsQ44110180
Gastric inhibitory polypeptide does not inhibit gastric emptying in humansQ44215026
Dipeptidyl peptidase-4 inhibitor ameliorates early renal injury through its anti-inflammatory action in a rat model of type 1 diabetesQ44403823
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Beneficial effects of vildagliptin on retinal injury in obese type 2 diabetic ratsQ44432573
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.Q44442300
Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemiaQ44452284
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Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired glucose toleranceQ44887107
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injuryQ45199143
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Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetesQ45250947
Sitagliptin reduces the urine albumin-to-creatinine ratio in type 2 diabetes through decreasing both blood pressure and estimated glomerular filtration rateQ45361069
Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states.Q45935416
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Sitagliptin reduces albuminuria in patients with type 2 diabetes.Q51382706
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GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humansQ58448859
Glucagon-Like Peptide I Enhances the Insulinotropic Effect of Glibenclamide in NIDDM Patients and in the Perfused Rat PancreasQ58449061
Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy SubjectsQ58449089
Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburideQ61836852
Dipeptidyl peptidase-IV inhibition prevents blood–retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic ratsQ61952009
Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal modelQ61952011
Molecular characterization of dipeptidyl peptidase activity in serumQ62660688
Gastric inhibitory polypeptide (GIP) and insulin in obesity: Increased response to stimulation and defective feedback control of serum levelsQ67275679
Interaction of gastric inhibitory polypeptide, glucose, and arginine on insulin and glucagon secretion from the perfused rat pancreasQ67442154
Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the ratQ70304238
A Gastric Inhibitory Polypeptide. I. The Amino Acid Composition and the Tryptic PeptidesQ71761356
Effect of ageing and diabetes on glucose-dependent insulinotropic polypeptide and dipeptidyl peptidase IV responses to oral glucoseQ73936311
NEW INTERPRETATION OF ORAL GLUCOSE TOLERANCEQ76819524
Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naïve patients with Type 2 diabetesQ80349827
Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic ratsQ82186212
The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cellsQ83343192
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthyperglycemiaQ271993
dipeptidyl peptidase-4 inhibitorsQ419770
type 2 diabetesQ3025883
mechanism of actionQ3271540
carbohydrateQ11358
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)806979
P577publication date2015-05-17
P1433published inJournal of Diabetes ResearchQ26841822
P1476titleThe Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?
P478volume2015

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