Galectin-3 in autoimmunity and autoimmune diseases

scientific article published on 03 July 2015

Galectin-3 in autoimmunity and autoimmune diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1177/1535370215593826
P8608Fatcat IDrelease_ran5pylbqjfxbio42cpk5teyj4
P932PMC publication ID4935288
P698PubMed publication ID26142116
P5875ResearchGate publication ID279726714

P50authorLeonardo PunziQ56419705
Andrea DoriaQ38544117
P2093author name stringRoberto Luisetto
Anna Ghirardello
Nicola Bassi
Mariele Gatto
Felipe L de Oliveira
P2860cites workExpression of galectin-3 modulates T-cell growth and apoptosisQ24309392
Galectin-3 regulates myofibroblast activation and hepatic fibrosisQ24546358
Rheumatoid arthritis susceptibility genes: An overviewQ26824670
Nuclear transport of galectin-3 and its therapeutic implicationsQ26824889
Basic and translational concepts of immune-mediated glomerular diseasesQ26995440
Review article: chemokines as orchestrators of autoimmune hepatitis and potential therapeutic targetsQ27025680
Multiple sclerosisQ28299151
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3Q28574963
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Interferon and granulopoiesis signatures in systemic lupus erythematosus bloodQ29615064
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-selfQ29619194
Autoantibodies in atopic dermatitisQ30982963
Anti-Galectin-3 IgG autoantibodies in patients with Crohn's disease characterized by means of phage display peptide librariesQ31031256
Identification of autoantibodies associated with systemic lupus erythematosusQ31087661
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylationQ32058522
The pathology of T cells in systemic lupus erythematosusQ33598213
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.Q33731760
Lack of galectin-3 disturbs mesenteric lymph node homeostasis and B cell niches in the course of Schistosoma mansoni infection.Q33900663
Immunoglobulin responses at the mucosal interface.Q34025272
Serum levels of galectin-3: possible association with fibrosis, aberrant angiogenesis, and immune activation in patients with systemic sclerosisQ40016270
The constitutive expression of galectin-3 is downregulated in the intestinal epithelia of Crohn's disease patients, and tumour necrosis factor alpha decreases the level of galectin-3-specific mRNA in HCT-8 cells.Q40735267
Galectin-3 down-regulates IL-5 gene expression on different cell typesQ41029757
Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.Q41120532
Lack of galectin-3 up-regulates IgA expression by peritoneal B1 lymphocytes during B cell differentiationQ41205968
Dissecting the immune cell mayhem that drives lupus pathogenesisQ41580653
Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathwaysQ42077799
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.Q42272758
GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell deathQ42324031
Galectin-3 modulates rat mesangial cell proliferation and matrix synthesis during experimental glomerulonephritis induced by anti-Thy1.1 antibodiesQ42474421
Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitisQ44361867
CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosisQ44695762
Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis.Q45859504
Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitisQ45876518
Discerning the kinetics of autoimmune manifestations in a model of Sjögren's syndromeQ45882170
Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?Q46095235
Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice.Q46323175
Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice.Q46471398
Regulation of galectin-3 function in mucosal fibroblasts: potential role in mucosal inflammationQ46705680
Spontaneous formation of germinal centers in autoimmune mice.Q47574161
Serum galectin-3 level in systemic sclerosisQ47866004
Sciatic nerve regeneration is accelerated in galectin-3 knockout miceQ47877781
The involvement of the spleen during chronic phase of Schistosoma mansoni infection in galectin-3-/- mice.Q50507379
Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection.Q51011747
Disease activity patterns in a monocentric cohort of SLE patients: a seven-year follow-up study.Q51188060
Nephritogenic-antinephritogenic antibody network in lupus glomerulonephritis.Q53141150
Psoriasis in humans is associated with down-regulation of galectins in dendritic cells.Q54327668
Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro.Q54460380
Prognosis of scleroderma renal crisis: a long-term observational studyQ61649506
Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerveQ61695764
Galectin-3 deficiency prevents concanavalin A-induced hepatitis in miceQ61903452
Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosusQ62620530
Glycophenotype of psoriatic skinQ62621726
Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitisQ70146489
Galectin-3/MAC-2 in experimental allergic encephalomyelitisQ73320823
Localization of galectin-3 in normal and diseased pancreatic tissueQ74372136
Kinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3 -/- miceQ80211016
Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microgliaQ81613971
Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritisQ83328154
Galectin-3 regulates peritoneal B1-cell differentiation into plasma cellsQ84441243
British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitisQ84561367
Disturbed Th17/Treg balance in patients with rheumatoid arthritisQ84644585
IL-17 contributes to autoimmune hepatitisQ84749635
Natural history of allergic sensitization in infants with early-onset atopic dermatitis: results from ORCA StudyQ85679868
Histopathological environment besides the focus score in Sjögren's syndromeQ85706432
Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosusQ85759970
Increased levels of serum galectin-3 in patients with primary Sjögren's syndrome: associated with interstitial lung diseaseQ88188489
Phagocytic properties of microglia in vitro: implications for a role in multiple sclerosis and EAE.Q34309554
Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damageQ34443260
Galectin-3: an open-ended storyQ34494555
Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosisQ34501897
Clinical implications of autoantibody screening in patients with autoimmune myositisQ34537296
Novel aspects of Sjögren's syndrome in 2012.Q34650103
The clinical features, diagnosis and classification of dermatomyositis.Q34659254
The regulation of inflammation by galectin-3.Q34991925
Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunityQ35088408
In-/off-label use of biologic therapy in systemic lupus erythematosusQ35094536
An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomasQ35096060
The etiology of glomerulonephritis: roles of infection and autoimmunityQ35118856
Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function.Q35302064
Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survivalQ35392528
Tolerogenic function of Blimp-1 in dendritic cellsQ35441479
Signatures of human regulatory T cells: an encounter with old friends and new playersQ35606024
Immune mechanisms of Concanavalin A model of autoimmune hepatitisQ35670435
Molecular mechanisms governing thymocyte migration: combined role of chemokines and extracellular matrixQ35691006
Soluble galectin-3 is a strong, colonic epithelial-cell-derived, lamina propria fibroblast-stimulating factorQ35761202
Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivoQ35780859
Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.Q35809897
Galectins as self/non-self recognition receptors in innate and adaptive immunity: an unresolved paradox.Q36093631
Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosusQ36102468
Galectin-3 modulates immune and inflammatory responses during helminthic infection: impact of galectin-3 deficiency on the functions of dendritic cellsQ36313888
Roles of galectin-3 in immune responses.Q36366397
Type-I interferon receptor deficiency reduces lupus-like disease in NZB miceQ36370602
Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene modelQ36900466
Roles of galectins in infectionQ37137327
Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitisQ37150796
Galectin-3 modulates Th17 responses by regulating dendritic cell cytokinesQ37218244
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.Q37298535
Galectin-3 regulates T-cell functionsQ37548637
Dysregulation of germinal centres in autoimmune disease.Q37638196
Cytokines and effector T cell subsets causing autoimmune CNS diseaseQ37863274
The pathology and immunology of atopic dermatitisQ37921834
Cytokine-based therapy in psoriasisQ37994612
Insight into Crohn's disease pathomorphologyQ38000028
Oligodendrocytes and the early multiple sclerosis lesionQ38029278
Emerging and critical issues in the pathogenesis of lupusQ38045660
IgA production and tonsillar focal infection in IgA nephropathyQ38069909
Serpins, immunity and autoimmunity: old molecules, new functionsQ38074594
Rituximab in refractory idiopathic inflammatory myopathies and antisynthetase syndrome: personal experience and review of the literatureQ38097748
Autoantibodies in polymyositis and dermatomyositisQ38099556
Treg cells in rheumatoid arthritis: an updateQ38124277
Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosisQ38134106
Importance of regulatory T cells in the pathogenesis of psoriasis: review of the literature.Q38139752
Galectin-3: a new biomarker for the diagnosis, analysis and prognosis of acute and chronic heart failureQ38148873
Research gaps in psoriasis: opportunities for future studies.Q38152571
Intracellular galectins in cancer cells: potential new targets for therapy (Review).Q38180976
Immune modulation in humans: implications for type 1 diabetes mellitus.Q38182297
Pathology of systemic lupus erythematosus: the challenges ahead.Q38185348
Microglial phagocytosis of live neuronsQ38197408
Dermatomyositis, polymyositis and immune-mediated necrotising myopathiesQ38218417
Role of galectin-3 in the initial control of Leishmania infectionQ38221174
Targeting apoptosis in autoimmune hepatitisQ38231217
The effect of cell death in the initiation of lupus nephritis.Q38231647
Functions of galectin-3 and its role in fibrotic diseasesQ38246458
Therapy of myositis: biological and physicalQ38246832
Multiple sclerosis and the role of immune cells.Q38254152
T cell mediated autoimmune glomerular disease in miceQ38264764
Galectin-3 modulates carbohydrate-dependent thymocyte interactions with the thymic microenvironment.Q38289730
Expression and function of galectin-3, a beta-galactoside-binding protein in activated T lymphocytesQ38301765
Galectin-3 gene (LGALS3) +292C allele is a genetic predisposition factor for rheumatoid arthritis in Taiwan.Q38336010
Up-regulation of galectin-3 and its ligands by Trypanosoma cruzi infection with modulation of adhesion and migration of murine dendritic cells.Q38343204
Immunoglobulin A nephropathy: current progress and future directionsQ38386988
Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritisQ38497448
Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretionQ40010233
P433issue8
P304page(s)1019-1028
P577publication date2015-07-03
P1433published inExperimental Biology and MedicineQ15716535
P1476titleGalectin-3 in autoimmunity and autoimmune diseases
P478volume240

Reverse relations

cites work (P2860)
Q91736618Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway
Q47718174Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction
Q54697325Clinical significance of galectin-3 in patients with adult acute myeloid leukemia: a retrospective cohort study with long-term follow-up and formulation of risk scoring system.
Q36708065Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens
Q47547850Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions
Q98177367Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions
Q99240850Evaluation of Galectin-3 as a Novel Diagnostic Biomarker in Patients with Heart Failure with Preserved Ejection Fraction
Q64949910Gal-3 Deficiency Suppresses Novosphyngobium aromaticivorans Inflammasome Activation and IL-17 Driven Autoimmune Cholangitis in Mice.
Q92312918Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives
Q48270428Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives
Q64094882Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms
Q90073141Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases
Q47329197Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review).
Q64097454Galectin-3 as a prognostic biomarker for diabetic nephropathy
Q50126684Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus
Q90640127Galectin-3 orchestrates the histology of mesentery and protects liver during lupus-like syndrome induced by pristane
Q57157917Galectin-3-Mediated Glial Crosstalk Drives Oligodendrocyte Differentiation and (Re)myelination
Q52804420Immunoglobulin E-Mediated Autoimmunity.
Q57000023Investigation of Gal-3 Expression Pattern in Serum and Cerebrospinal Fluid of Patients Suffering From Neurodegenerative Disorders
Q48271668Lactosamine-Based Derivatives as Tools to Delineate the Biological Functions of Galectins: Application to Skin Tissue Repair
Q89965075Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice
Q37339791Prognostic value of plasma galectin-3 levels after aneurysmal subarachnoid hemorrhage
Q99565582Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling
Q38689543Retrospective Proteomic Screening of 100 Breast Cancer Tissues.
Q47302001Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein can reflect systemic lupus erythematosus activity.
Q41449179Serum galectin-3 levels and delirium among postpartum intensive care unit women.
Q50895945Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation.
Q33760199The Many Roles of Galectin-3, a Multifaceted Molecule, in Innate Immune Responses against Pathogens.
Q92152673The Phenotype and Secretory Activity of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Patients with Rheumatic Diseases

Search more.