Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review).

scientific article published on 5 December 2017

Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review). is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3892/IJMM.2017.3311
P932PMC publication ID5752178
P698PubMed publication ID29207027

P2093author name stringMin Zhang
Hui Yuan
Rui Dong
Yijie Zheng
Shan Zheng
Andrew Soh
Qunying Hu
P2860cites workCod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasisQ24597542
The Role of Galectin-3 in the KidneysQ26752754
Galectin-3 in heart failure pathology--"another brick in the wall"?Q26801422
Galectin-3 in angiogenesis and metastasis.Q27687444
Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan RecognitionQ27714964
A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis ModelQ27726385
Up-regulation of galectin-3 in acute renal failure of the ratQ28344724
Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH.Q30587543
Galectin-1 and Galectin-3 mRNA expression in renal cell carcinomaQ33631354
Comparison the prognostic value of galectin-3 and serum markers of cardiac extracellular matrix turnover in patients with chronic systolic heart failureQ34102031
Cytokeratin 19, thyroperoxidase, HBME-1 and galectin-3 in evaluation of aggressive behavior of papillary thyroid carcinomaQ34167262
Galectin-3--a jack-of-all-trades in cancerQ34221519
Galectin-3 as a marker and potential therapeutic target in breast cancerQ34257030
Galectin-3 is associated with a poor prognosis in primary hepatocellular carcinomaQ34265995
Expression of galectin-3 in gastric adenocarcinomaQ34272154
Galectin-3 and left ventricular reverse remodelling after surgical mitral valve repairQ34338521
Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stressQ34413483
Clinicopathlogic and immunohistochemical characteristics of triple negative invasive lobular carcinoma.Q34474679
Galectin-3: an open-ended storyQ34494555
Assessment of the Relationship between Galectin-3 and Ejection Fraction and Functional Capacity in the Patients with Compensated Systolic Heart FailureQ34997796
Therapy of experimental NASH and fibrosis with galectin inhibitorsQ35075568
Prognostic significance of serum galectin-3 levels in patients with hepatocellular cancer and chronic viral hepatitisQ35166192
The prognostic value of plasma galectin-3 in chronic heart failure patients is maintained when treated with mineralocorticoid receptor antagonistsQ35191679
Prognostic value of sST2 and galectin-3 for death relative to renal function in patients hospitalized for heart failureQ41731823
Can be galectin-3 a novel marker in determining mortality in hemodialysis patients?Q41736786
The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.Q41744993
Focus on Molecules: Galectin-3Q41954196
Association between circulating galectin-3 levels and the immunological, inflammatory and nutritional parameters in patients with colorectal cancerQ42177420
Galectin-3 levels in patients with hypertrophic cardiomyopathy and its relationship with left ventricular mass index and functionQ42191449
Immunochemiluminescent detection of galectin-3 in tumoral tissue from prostate.Q42580165
The association between galectin-3 and clinical parameters in patients with first acute myocardial infarction treated with primary percutaneous coronary angioplastyQ43440923
Clinicopathological significance of decreased galectin-3 expression and the long-term prognosis in patients with breast cancerQ43559327
Galectin-3 expression in thyroid fine needle cytology (t-FNAC) uncertain cases: validation of molecular markers and technology innovationQ44053611
Elevated plasma galectin-3 is associated with near-term rehospitalization in heart failure: a pooled analysis of 3 clinical trialsQ44080331
Head-to-head comparison of 2 myocardial fibrosis biomarkers for long-term heart failure risk stratification: ST2 versus galectin-3.Q44118879
Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patientsQ44253238
Serial measurement of galectin-3 in patients with chronic heart failure: results from the ProBNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) studyQ44480518
Galectin-3 expression in prostate cancer and benign prostate tissues: correlation with biochemical recurrenceQ44523706
Contribution of immunocytochemical stainings for galectin-3, CD44, and HBME1 to fine-needle aspiration cytology diagnosis of papillary thyroid carcinomaQ44833175
The association between galectin-3 and occurrence of reinfarction early after first myocardial infarction treated invasivelyQ45129579
Galectin-3 expression in pituitary adenomas as a marker of aggressive behaviorQ45189766
Predictive value of serum galectin-3 levels in patients with acute heart failure with preserved ejection fractionQ45202266
Prognostic value of epidermal growth factor receptor, p53 and galectin-3 expression in papillary thyroid carcinomaQ45853721
Galectin-3 and Soluble ST2 and Kidney Function Decline in Older Adults: The Cardiovascular Health Study (CHS).Q46506580
Usefulness of a combination of monocyte chemoattractant protein-1, galectin-3, and N-terminal probrain natriuretic peptide to predict cardiovascular events in patients with coronary artery diseaseQ46557284
Biological variation of galectin-3 and soluble ST2 for chronic heart failure: implication on interpretation of test resultsQ46699762
The utility of galectin-3 for predicting cause-specific death in hospitalized patients with heart failureQ46867879
Immunohistochemical expression of HBME-1 and galectin-3 in the differential diagnosis of follicular-derived thyroid nodulesQ46982250
Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumorsQ47208349
Galectin-3 predicts left ventricular remodelling after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention.Q48035204
Baseline and serial measurements of galectin-3 in patients with heart failure: relationship to prognosis and effect of treatment with valsartan in the Val-HeFT.Q48546353
Estimating systemic fibrosis by combining galectin-3 and ST2 provides powerful risk stratification value for patients after acute decompensated heart failure.Q48575472
Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trialQ48750580
GALECTIN-3 AS A PROGNOSTIC BIOMARKER IN PATIENTS WITH NON-HODGKIN LYMPHOMA.Q49162730
Up-regulation of galectin-3 and Sambucus nigra agglutinin binding site is associated with invasion, metastasis and poor-progression of the gallbladder adenocarcinomaQ50174633
Galectin-3 Predicts Left Ventricular Remodeling of HypertensionQ86955911
Serial galectin-3 for the monitoring of optimally treated stable chronic heart failure: A pilot studyQ87155350
Comparison of fibroblast growth factor 23, soluble ST2 and Galectin-3 for prognostication of cardiovascular death in heart failure patientsQ87160068
Galectin-3 as a new biomarker of diastolic dysfunction in hemodialysis patientsQ87341099
Long-term biological variability of galectin-3 after heart transplantationQ87385794
Expression and clinical significance of galectin-3 in osteosarcomaQ87790701
Galectin-3 and PTEN expression in pancreatic ductal adenocarcinoma, pancreatic neuroendocrine neoplasms and gastrointestinal tumors on fine-needle aspiration cytologyQ87934701
Relationship of galectin-3 to left ventricular geometry and hypertrophy in chronic hemodialysis patientsQ88069565
Assessment of relationship between galectin-3 and ambulatory ECG-based microvolt T-wave alternans in sustained systolic-diastolic hypertension patientsQ89300184
Galectin-3 in patients with chronic heart failure: association with oxidative stress, inflammation, renal dysfunction and prognosisQ89305965
Diagnostic value of HBME-1, CD56, Galectin-3 and Cytokeratin-19 in papillary thyroid carcinomas and thyroid tumors of uncertain malignant potentialQ95579418
Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure).Q35206146
Serum galectin-3 as a potential marker for gastric cancerQ35207994
Utility of galectin-3 as a prognostic biomarker in heart failure: where do we stand?Q35286926
Galectin-3 in patients with atrial fibrillation undergoing radiofrequency catheter ablationQ35432573
Changes in the expression and subcellular distribution of galectin-3 in clear cell renal cell carcinomaQ35563015
Galectin 3 for the diagnosis of bladder cancer.Q35616489
Galectin-3, Renal Function, and Clinical Outcomes: Results from the LURIC and 4D StudiesQ36003071
Galectin 3: association to neurohumoral activity, echocardiographic parameters and renal function in outpatients with heart failure.Q36035702
Dynamics and prognostic role of galectin-3 in patients with advanced heart failure, during left ventricular assist device support and following heart transplantationQ36052222
Galectin 3 regulates HCC cell invasion by RhoA and MLCK activationQ36101399
Galectin-3 Immunohistochemical Expression in Thyroid NeoplasmsQ36343453
Serum Galectin-3: diagnostic value for papillary thyroid carcinomaQ36358669
Galectin-3: A Link between Myocardial and Arterial Stiffening in Patients with Acute Decompensated Heart Failure?Q36611468
Prognostic Value of Galectin-3 for Adverse Outcomes in Chronic Heart FailureQ36757833
Sensitivity and Specificity of Galectin-3 and Glypican-3 in Follicular-Patterned and Other Thyroid NeoplasmsQ36831011
Circulating Galectin-3 Is Associated With Cardiometabolic Disease in the CommunityQ36877555
Galectin-3 Is Elevated and Associated With Adverse Outcomes in Patients With Single-Ventricle Fontan CirculationQ36877769
Galectin-3 and Risk of Heart Failure and Death in Blacks and WhitesQ36956715
Galectin-3: a possible complementary marker to the PSA blood testQ37038393
Role of galectin-3 and plasma B type-natriuretic peptide in predicting prognosis in discharged chronic heart failure patientsQ37077973
Elevated galectin-3 precedes the development of CKDQ37119904
Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation OutcomesQ37164851
Low expression of galectin-3 is associated with poor survival in node-positive breast cancers and mesenchymal phenotype in breast cancer stem cellsQ37299331
Prognostic value of plasma galectin-3 levels after aneurysmal subarachnoid hemorrhageQ37339791
Role for Galectin-3 in Calcific Aortic Valve Stenosis.Q37556207
Positive associations between galectin-3 and PSA levels in prostate cancer patients: a prospective clinical study-I.Q37696115
The pleiotropic effects of galectin-3 in neuroinflammation: a reviewQ38073036
Galectin-3 in diabetic patientsQ38221153
Galectin-3 Serum Levels Are Independently Associated With Microalbuminuria in Chronic Heart Failure OutpatientsQ38309028
Prognostic value of serum galectin-3 in patients with heart failure: a meta-analysisQ38314021
Galectin-3 inhibition prevents adipose tissue remodelling in obesity.Q38382993
Changes in the expression pattern of apoptotic molecules (galectin-3, Bcl-2, Bax, survivin) during progression of thyroid malignancy and their clinical significanceQ38388971
Combined immunohistochemistry for thyroid peroxidase, galectin-3, CK19 and HBME-1 in differential diagnosis of thyroid tumorsQ38404012
Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertensionQ38410318
Galectin-3 and cardiac function in survivors of acute myocardial infarction.Q38454450
Galectin-3 and post-myocardial infarction cardiac remodeling.Q38534975
Galectin-3 in autoimmunity and autoimmune diseasesQ38542678
Galectin 3 as a guardian of the tumor microenvironmentQ38564732
Comparative study of galectin-3 and B-type natriuretic peptide as biomarkers for the diagnosis of heart failureQ38687046
Galectin-3 may serve as a potential marker for diagnosis and prognosis in papillary thyroid carcinoma: a meta-analysisQ38727024
Galectin-3: A key player in arthritis.Q38847703
High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid EndarterectomyQ38915953
Galectin-1 and galectin-3: plausible tumour markers for oral squamous cell carcinoma and suitable targets for screening high-risk population.Q38921176
Galectin-3 inhibition suppresses drug resistance, motility, invasion and angiogenic potential in ovarian cancerQ38950425
Role of galectin-3 in autoimmune and non-autoimmune nephropathiesQ38964155
Galectin-3 and matrix metalloproteinase-9: Perspective in management of hepatocellular carcinoma.Q38983451
Prognostic value of plasma galectin-3 levels in patients with coronary heart disease and chronic heart failureQ39015148
Evaluation of Annexin A7, Galectin-3 and Gelsolin as possible biomarkers of hepatocarcinoma lymphatic metastasisQ39023762
Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient miceQ39191329
Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosisQ39251941
Diagnostic and prognostic value of galectin-3, serum creatinine, and cystatin C in chronic kidney diseases.Q39303610
Treatment of prostate carcinoma with (galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugatesQ39424439
Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endotheliumQ39470886
Clinical significance of Galectin-3 in clear cell renal cell carcinomaQ39725948
Predictive Value for Galectin 3 and Cardiotrophin 1 in Hemodialysis PatientsQ40085529
Galectin-3 and sST2 in prediction of left ventricular ejection fraction after myocardial infarctionQ40362335
Prognostic Utility of Galectin-3 for Recurrent Cardiovascular Events During Long-term Follow-up in Patients with Stable Coronary Heart Disease: Results of the KAROLA StudyQ40615816
Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhageQ40616519
Soluble ST2 and galectin-3 in pediatric patients without heart failureQ40638926
Differences in galectin-3, a biomarker of fibrosis, between participants with peripheral artery disease and participants with normal ankle-brachial indexQ40765198
Determinants and prognostic value of Galectin-3 in patients with aortic valve stenosisQ40898595
Plasma galectin-3 predicts clinical outcomes after catheter ablation in persistent atrial fibrillation patients without structural heart diseaseQ41002506
Co-expression of galectin-3 and CRIP-1 in endometrial cancer: prognostic value and patient survivalQ41018493
Serum PINP, PIIINP, galectin-3, and ST2 as surrogates of myocardial fibrosis and echocardiographic left venticular diastolic filling propertiesQ41111574
Value of pentraxin-3 and galectin-3 in acute coronary syndrome: a short-term prospective cohort studyQ41151739
Serum Galectin-3 Levels Predict Recurrences after Ablation of Atrial FibrillationQ41203031
The role of timely measurement of galectin-3, NT-proBNP, cystatin C and hsTnT in predicting prognosis and heart function after heart transplantationQ41385684
Diagnostic and Prognostic Significance of Serum and Tissue Galectin 3 Expression in Patients with Carcinoma of the BladderQ41661749
Utility of galectin-3 in predicting post-infarct remodeling after acute myocardial infarction based on extracellular volume fraction mapping.Q50230482
Circulating Galectin-3 Levels Are Increased in Patients with Ischemic Heart Disease, but Are Not Influenced by Acute Myocardial Infarction.Q50657992
Correlations between echocardiographic parameters of right ventricular dysfunction and Galectin-3 in patients with chronic obstructive pulmonary disease and pulmonary hypertension.Q50759276
Short- and Long-term Biologic Variability of Galectin-3 and Other Cardiac Biomarkers in Patients with Stable Heart Failure and Healthy Adults.Q50961741
Prognostic Value of Serial Measurements of Soluble Suppression of Tumorigenicity 2 and Galectin-3 in Ambulatory Patients With Chronic Heart Failure.Q50994916
Renal function largely influences Galectin-3 prognostic value in heart failure.Q50995380
Predictive value of plasma galectin-3 in patients with chronic heart failure.Q51005416
Circulating and tissue galectin-1 and galectin-3 in colorectal carcinoma: association with clinicopathological parameters, serum CEA, IL-17 and IL23.Q51448643
RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways.Q51518944
Circulating Galectin-3 Levels Are Persistently Elevated After Heart Transplantation and Are Associated With Renal Dysfunction.Q51521537
Clinical benefits of natriuretic peptides and galectin-3 are maintained in old dyspnoeic patients.Q51525964
New onset atrial fibrillation is associated with elevated galectin-3 levels.Q51568519
Galectin-3, Cardiac Function, and Fibrosis.Q51614488
A pilot study to demonstrate diagnostic potential of galectin-3 levels in saliva.Q51684100
Diagnostic significance of serum galectin-3 levels in heart failure with preserved ejection fraction.Q52139416
Additional value of Galectin-3 to BNP in acute heart failure patients with preserved ejection fraction.Q52140822
The Relationship between Galectin-3 and Different Patterns of Ventricular Geometry Remodelling in Aortic Valve Stenosis.Q52147262
Galectin-3 and prediction of therapeutic response to renal sympathetic denervation.Q52852604
The relation among aldosterone, galectin-3, and myocardial fibrosis: a prospective clinical pilot follow-up study.Q53099098
The expression profiles of the galectin gene family in primary and metastatic papillary thyroid carcinoma with particular emphasis on galectin-1 and galectin-3 expression.Q53099826
Clinical Significance of Serum Galectin-3 Levels in Gastric Cancer Patients.Q53131400
Value and level of galectin-3 in acute myocardial infarction patients undergoing primary percutaneous coronary intervention.Q53141520
Can galectin-3 be a useful marker for conventional papillary thyroid microcarcinoma?Q53180493
The expressions and clinical significances of tissue and serum galectin-3 in pancreatic carcinoma.Q53183087
Inhibition of Galectin-3 Pathway Prevents Isoproterenol-Induced Left Ventricular Dysfunction and Fibrosis in Mice.Q53205052
Is galectin-3 a biomarker, a player-or both-in the presence of coronary atherosclerosis?Q53233664
Temporal expression of galectin-3 following myocardial infarction.Q53621883
Galectin-3 predicts long-term cardiovascular death in high-risk patients with coronary artery disease.Q53630691
Potential tumor markers of renal cell carcinoma: α-enolase for postoperative follow up, and galectin-1 and galectin-3 for primary detection.Q53766231
Clinical significance of galectin-3 in patients with adult acute myeloid leukemia: a retrospective cohort study with long-term follow-up and formulation of risk scoring system.Q54697325
Within-day variation and influence of physical exercise on circulating Galectin-3 in patients with rheumatoid arthritis and healthy individualsQ57832125
Galectin-3 and HBME-1 improve the accuracy of core biopsy in indeterminate thyroid nodulesQ58005853
Determinants in the N-terminal domains of galectin-3 for secretion by a novel pathway circumventing the endoplasmic reticulum-Golgi complexQ73003369
The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cellsQ73336750
Embryonic implantation in galectin 1/galectin 3 double mutant miceQ74498015
Expression of cytokeratin 19, HBME-1 and galectin-3 in neoplastic and nonneoplastic thyroid lesionsQ83997734
Role of carbonic anhydrase IX, α-methylacyl coenzyme a racemase, cytokeratin 7, and galectin-3 in the evaluation of renal neoplasms: a tissue microarray immunohistochemical studyQ84811190
Intensity and distribution of immunohistochemical expression of galectin-3 in thyroid neoplasmsQ85330513
Simultaneous determination of serum galectin-3 and -4 levels detects metastases in colorectal cancer patientsQ85335269
Role of pro-angiogenic marker galectin-3 in follicular neoplasms of thyroidQ85760695
Galectin-3 and plasma cytokines in patients with acute myocardial infarctionQ85791700
Galectin-3, Carotid Plaque Vulnerability, and Potential Effects of Statin TherapyQ86132126
Effects of persistent atrial fibrillation on serum galectin-3 levelsQ86565477
The Association of Serum Galectin-3 Levels with Atrial Electrical and Structural RemodelingQ86740856
Galectin-3 and myocardial fibrosis in nonischemic dilated cardiomyopathyQ86776867
Evaluation of galectin-3 levels in acute coronary syndromeQ86831580
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivativesQ6937225
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectheart diseaseQ190805
biomarkerQ864574
kidney diseaseQ1054718
neoplasmQ1216998
Galectin 3Q3094567
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)599-614
P577publication date2017-12-05
2018-02-01
P1433published inInternational Journal of Molecular MedicineQ6051492
P1476titleGalectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review).
P478volume41

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