Transforming growth factor-β regulates the growth of valve interstitial cells in vitro

scientific article published on 16 August 2011

Transforming growth factor-β regulates the growth of valve interstitial cells in vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.AJPATH.2011.06.007
P932PMC publication ID3181399
P698PubMed publication ID21851806
P5875ResearchGate publication ID51580937

P2093author name stringChen Li
Avrum I Gotlieb
P2860cites workSB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7Q24299813
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Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cellsQ24646540
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Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemiaQ30487144
Cardiac valve interstitial cells secrete fibronectin and form fibrillar adhesions in response to injuryQ33291099
Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transitionQ33411645
Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferationQ33583459
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TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loopQ68482825
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Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valvesQ77198147
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Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2Q81480914
Targeted disruption of TGF-beta-Smad3 signaling leads to enhanced neointimal hyperplasia with diminished matrix deposition in response to vascular injuryQ81575610
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SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.Q38339796
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TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrestQ39883204
TGF-beta induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1.Q39913896
TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma proteinQ40242882
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TGF-beta1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27(Kip1) CDK inhibitor in hepatoma cells replated on fibronectinQ40445197
SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivoQ40497236
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The effect of TGF-beta 1 on cell proliferation and proteoglycan production in human melanoma cells depends on the degree of cell differentiationQ41145976
Characterization of Cobblestone mitral valve interstitial cellsQ41157221
Transforming growth factor-beta inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-I.Q41607585
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylationQ41728185
Transforming growth factor-beta regulates in vitro heart valve repair by activated valve interstitial cellsQ42160598
Interstitial cells of the heart valves possess characteristics similar to smooth muscle cellsQ42525839
TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cellsQ42917997
Transforming growth factor-beta1 modulates expression of adhesion and cytoskeletal proteins in human peritoneal fibroblastsQ44048880
Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosisQ44329666
Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.Q51601913
Cyclin-dependent kinases and cell-cycle transitions: does one fit all?Q53451934
Growth inhibition induced by transforming growth factor-beta1 in human oral squamous cell carcinoma.Q53483198
Vascular cell apoptosis: cell type-specific modulation by transforming growth factor-beta1 in endothelial cells versus smooth muscle cells.Q54099166
Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic ValvesQ63341951
Bovine mitral valve organ culture: role of interstitial cells in repair of valvular injuryQ68054738
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1746-1755
P577publication date2011-08-16
P1433published inThe American Journal of PathologyQ4744259
P1476titleTransforming growth factor-β regulates the growth of valve interstitial cells in vitro
P478volume179

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cites work (P2860)
Q91869856FGF-2 inhibits contractile properties of valvular interstitial cell myofibroblasts encapsulated in 3D MMP-degradable hydrogels
Q42501448Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle
Q41022393Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis
Q26764864Involvement of Immune Cell Network in Aortic Valve Stenosis: Communication between Valvular Interstitial Cells and Immune Cells
Q26781699Mitral valve disease--morphology and mechanisms
Q41651926Role of cell-matrix interactions on VIC phenotype and tissue deposition in 3D PEG hydrogels
Q27336001Sex-related differences in gene expression by porcine aortic valvular interstitial cells
Q36943410TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves

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