Recent Insights into the Structure, Regulation, and Function of the V-ATPases

scientific article published on October 2015

Recent Insights into the Structure, Regulation, and Function of the V-ATPases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TIBS.2015.08.005
P932PMC publication ID4589219
P698PubMed publication ID26410601

P2093author name stringMichael Forgac
Christina McGuire
Kristina Cotter
Laura Stransky
P2860cites workRegulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiaeQ42559102
Protein kinase A-dependent and -independent activation of the V-ATPase in Malpighian tubules of Aedes aegyptiQ42986753
Subunit interactions and requirements for inhibition of the yeast V1-ATPaseQ43131524
Activation of lysosomal function during dendritic cell maturationQ44333919
TM2 but not TM4 of subunit c'' interacts with TM7 of subunit a of the yeast V-ATPase as defined by disulfide-mediated cross-linkingQ45024984
Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunitQ47072606
Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase.Q47435178
V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosisQ48703764
Reversible disassembly of the yeast V-ATPase revisited under in vivo conditionsQ50456670
Topology, glycosylation and conformational changes in the membrane domain of the vacuolar H+-ATPase a subunit.Q50485436
Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.Q52940505
Expression and functional role of vacuolar H(+)-ATPase in human hepatocellular carcinoma.Q53264733
Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma.Q54431765
Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension.Q54442297
The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cellsQ84352261
Probing subunit-subunit interactions in the yeast vacuolar ATPase by peptide arraysQ21133947
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signalingQ24296846
Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pumpQ24311929
Rabconnectin-3 is a functional regulator of mammalian Notch signalingQ24621274
Structure of the yeast vacuolar ATPaseQ24645117
Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migrationQ27315048
Crystal structure of A3B3 complex of V-ATPase from Thermus thermophilusQ27658075
Crystal Structure of the Cytoplasmic N-Terminal Domain of Subunit I, a Homolog of Subunit a, of V-ATPaseQ27670991
Crystal Structure of the Yeast Vacuolar ATPase Heterotrimeric EGChead Peripheral Stalk ComplexQ27673538
The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.Q27675740
Crystal structure of the central axis DF complex of the prokaryotic V-ATPaseQ27675786
Subnanometre-resolution structure of the intact Thermus thermophilus H+-driven ATP synthaseQ27676276
Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPaseQ27700838
The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles.Q27931031
Yeast phosphofructokinase-1 subunit Pfk2p is necessary for pH homeostasis and glucose-dependent vacuolar ATPase reassemblyQ27931757
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cellsQ28119089
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiologyQ29614686
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPaseQ29616153
Rabconnectin3α promotes stable activity of the H+ pump on synaptic vesicles in hair cellsQ30458329
cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells.Q30493671
The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machineryQ30555694
Subunit positioning and stator filament stiffness in regulation and power transmission in the V1 motor of the Manduca sexta V-ATPaseQ30566693
Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c.Q30843900
Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector.Q33545239
Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinaseQ33568911
Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells.Q33694769
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosaQ42487320
PA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanismQ33718555
The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptorQ33840072
The second stalk of Escherichia coli ATP synthaseQ33933667
Regulation of vacuolar proton-translocating ATPase activity and assembly by extracellular pHQ34025366
Domain characterization and interaction of the yeast vacuolar ATPase subunit C with the peripheral stator stalk subunits E and G.Q34042638
PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cellsQ34042653
Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPaseQ34085868
V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cellsQ34163369
A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPaseQ34319285
On the role of v-ATPase V0a1-dependent degradation in Alzheimer diseaseQ34570266
pH-dependent cargo sorting from the GolgiQ34695491
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancerQ34883535
The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.Q34975697
Nutrient-sensing mechanisms and pathways.Q35036374
Crystal structure of subunits D and F in complex gives insight into energy transmission of the eukaryotic V-ATPase from Saccharomyces cerevisiaeQ35055454
Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cellsQ35055604
Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cellsQ35086788
Consequences of loss of Vph1 protein-containing vacuolar ATPases (V-ATPases) for overall cellular pH homeostasisQ35150095
Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPaseQ35266910
Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancerQ35551874
Vacuolar H+-ATPase works in parallel with the HOG pathway to adapt Saccharomyces cerevisiae cells to osmotic stressQ35804688
Subunit interactions at the V1-Vo interface in yeast vacuolar ATPaseQ35921635
Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1pQ36003848
Epidermal growth factor-induced vacuolar (H+)-atpase assembly: a role in signaling via mTORC1 activationQ36122272
Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.Q36417407
ABCG2/V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cellsQ36524281
Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusionQ36555298
Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F.Q36690941
Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytesQ37031465
Obstruction of transmembrane helical movements in subunit a blocks proton pumping by F1Fo ATP synthaseQ37132174
Regulation of luminal acidification by the V-ATPaseQ37158489
AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidneyQ37234794
Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.Q37249049
Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cellsQ37269119
The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cellsQ37289316
Structural analysis of the N-terminal domain of subunit a of the yeast vacuolar ATPase (V-ATPase) using accessibility of single cysteine substitutions to chemical modificationQ37311994
The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in DrosophilaQ37378404
Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymisQ37476423
Atp6v1c1 may regulate filament actin arrangement in breast cancer cellsQ37483783
Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathwayQ37488444
The RAVE complex is an isoform-specific V-ATPase assembly factor in yeastQ37533677
The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPaseQ37696871
Targeting reversible disassembly as a mechanism of controlling V-ATPase activityQ37951590
Vacuolar-type proton pump ATPases: acidification and pathological relationshipsQ38086477
Eukaryotic V-ATPase: novel structural findings and functional insightsQ38186369
Regulation of TFEB and V-ATPases by mTORC1.Q38256715
Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding siteQ38294393
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancerQ38317885
Expression and role of V1A subunit of V-ATPases in gastric cancer cellsQ38912831
Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway.Q38950999
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolismQ38977354
V-ATPase regulates communication between microvascular endothelial cells and metastatic cellsQ39017570
V-ATPase inhibition regulates anoikis resistance and metastasis of cancer cells.Q39028592
V-ATPase as an effective therapeutic target for sarcomasQ39035024
Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signalingQ39048013
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivoQ39069422
V-ATPase is a candidate therapeutic target for Ewing sarcomaQ39167742
Metabolism. Differential regulation of mTORC1 by leucine and glutamineQ39211265
Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibitionQ39241615
The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signallingQ39269454
The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.Q39276731
Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasisQ39326747
The renal v-ATPase a4 subunit is expressed in specific subtypes of human gliomasQ39372069
Iejimalides A and B inhibit lysosomal vacuolar H+-ATPase (V-ATPase) activity and induce S-phase arrest and apoptosis in MCF-7 cellsQ39758112
Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.Q39781832
Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPaseQ41500748
Structure of the vacuolar-type ATPase from Saccharomyces cerevisiae at 11-Å resolutionQ41792129
The Ras/cAMP/protein kinase A pathway regulates glucose-dependent assembly of the vacuolar (H+)-ATPase in yeastQ41829576
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeastQ41970961
The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid.Q42012323
Homotypic vacuole fusion in yeast requires organelle acidification and not the V-ATPase membrane domain.Q42105526
P433issue10
P1104number of pages12
P304page(s)611-622
P577publication date2015-10-01
P1433published inTrends in Biochemical SciencesQ1565711
P1476titleRecent Insights into the Structure, Regulation, and Function of the V-ATPases
P478volume40

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cites work (P2860)
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