The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase (scientific article published on 12 February 2014)

PIKfyve Controls Fluid Phase Endocytosis but Not Recycling/Degradation of Endocytosed Receptors or Sorting of Procathepsin D by Regulating Multivesicular Body Morphogenesis

Q24297560

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse

Q24318746

Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

Q24515262

The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans

Q24548664

The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice

Q24618677

Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase

Q24643186

Structure of the yeast vacuolar ATPase

Q24645117

Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors

Q24671705

Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.

Q24678783

The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover

Q24683845

Crystal Structure of the Cytoplasmic N-Terminal Domain of Subunit I, a Homolog of Subunit a, of V-ATPase

Q27670991

Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy

Q27681186

Phosphoinositides in cell regulation and membrane dynamics

Q27861051

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

Q27861085

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p

Q27930743

Fab1p Is Essential for PtdIns(3)P 5-Kinase Activity and the Maintenance of Vacuolar Size and Membrane Homeostasis

Q27931112

Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body

Q27932192

Novel Vacuolar H+-ATPase Complexes Resulting from Overproduction of Vma5p and Vma13p

Q27932640

Role of vacuolar acidification in protein sorting and zymogen activation: a genetic analysis of the yeast vacuolar proton-translocating ATPase

Q27933484

Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae

Q36768641

PIP2 is a necessary cofactor for ion channel function: how and why?

Q37197976

The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila

Q37378404

Regulation by salt of vacuolar H+-ATPase and H+-pyrophosphatase activities and Na+/H+ exchange

Q37612731

Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.

Q37898748

PIKfyve and its Lipid Products in Health and in Sickness

Q38053955

On the physiological roles of PIP(2) at cardiac Na+ Ca2+ exchangers and K(ATP) channels: a long journey from membrane biophysics into cell biology

Q38573614

Structural Basis for Endosomal Targeting by FYVE Domains

Q40620748

Phosphoinositides as regulators in membrane traffic

Q40968891

Structure of the vacuolar-type ATPase from Saccharomyces cerevisiae at 11-Å resolution

Q41792129

A different conformation for EGC stator subcomplex in solution and in the assembled yeast V-ATPase: possible implications for regulatory disassembly

Q41792154

Stimulus-induced phosphorylation of vacuolar H(+)-ATPase by protein kinase A.

Q42031982

Weak acid and alkali stress regulate phosphatidylinositol bisphosphate synthesis in Saccharomyces cerevisiae

Q42128054

Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae

Q42559102

Atg18 phosphoregulation controls organellar dynamics by modulating its phosphoinositide-binding activity

Q42560292

Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.

Q42924633

Methods for studying the yeast vacuole

Q44041860

Three-dimensional structure of the vacuolar ATPase proton channel by electron microscopy

Q44077049

Partial assembly of the yeast vacuolar H(+)-ATPase in mutants lacking one subunit of the enzyme.

Q45092115

Activity of tonoplast proton pumps and Na+/H+ exchange in potato cell cultures is modulated by salt.

Q46123589

RAVE is essential for the efficient assembly of the C subunit with the vacuolar H(+)-ATPase

Q80595390

Vacuole Size Control: Regulation of PtdIns(3,5)P2Levels by the Vacuole-associated Vac14-Fig4 Complex, a PtdIns(3,5)P2-specific Phosphatase

Q27933521

The amino-terminal domain of the vacuolar proton-translocating ATPase a subunit controls targeting and in vivo dissociation, and the carboxyl-terminal domain affects coupling of proton transport and ATP hydrolysis.

Q27939014

Assembly and targeting of peripheral and integral membrane subunits of the yeast vacuolar H(+)-ATPase

Q27939259

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

Q27939343

The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase

Q27939895

The H subunit (Vma13p) of the yeast V-ATPase inhibits the ATPase activity of cytosolic V1 complexes

Q28142904

Cryo-electron microscopy of the vacuolar ATPase motor reveals its mechanical and regulatory complexity

Q28236433

Disassembly and reassembly of the yeast vacuolar H(+)-ATPase in vivo

Q28294160

Biochemical and biophysical properties of interactions between subunits of the peripheral stalk region of human V-ATPase

Q28486120

Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

Q28511673

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

Q29543488

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

Q29546523

A guided tour into subcellular colocalization analysis in light microscopy

Q29547199

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

Q29614686

Membrane recognition by phospholipid-binding domains

Q29614848

Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration

Q30489465

Lysosome dysfunction triggers Atg7-dependent neural apoptosis

Q33796094

Phosphatidylinositol 3,5-bisphosphate: a novel lipid that links stress responses to membrane trafficking events

Q33985634

Regulation of vacuolar proton-translocating ATPase activity and assembly by extracellular pH

Q34025366

Domain characterization and interaction of the yeast vacuolar ATPase subunit C with the peripheral stator stalk subunits E and G.

Q34042638

Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H.

Q34348713

A genomic screen for yeast vacuolar membrane ATPase mutants

Q34348722

Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

Q34446025

Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels

Q34512579

Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.

Q34913669

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

Q35005794

Vacuolar H+-ATPase works in parallel with the HOG pathway to adapt Saccharomyces cerevisiae cells to osmotic stress

Q35804688

Phosphoinositides in constitutive membrane traffic.

Q35842974

Subunit Interactions at the V1-Vo Interface in Yeast Vacuolar ATPase

Q35921635

Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p

Q36003848

Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

Q36142866

SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity

Q36315865

The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPase

Q36416690

Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

Q36583080

Function and subunit interactions of the N-terminal domain of subunit a (Vph1p) of the yeast V-ATPase

Q36744179

P4510

describes a project that uses

ImageJ

Q1659584

P433

issue

P304

page(s)

1251-1262

P577

publication date

2014-02-12

P1433

published in

Molecular Biology of the Cell

Q2338259

P1476

title

The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase

P478

volume

Reverse relations

cites work (P2860)

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P356	DOI	10.1091/MBC.E13-10-0563
P932	PMC publication ID	3982991
P698	PubMed publication ID	24523285