LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer

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LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1091167146
P356DOI10.1186/S13148-017-0382-Y
P932PMC publication ID5553900
P698PubMed publication ID28811844

P50authorBarbara A FosterQ99207628
Bryan GillardQ123019126
Ellen KarasikQ123019128
P2093author name stringJennifer Williams
Sebastiano Battaglia
Michael T Moser
Dominic J Smiraglia
Trisha Winchester
P2860cites workp53 is regulated by the lysine demethylase LSD1Q24292925
The functional interactome landscape of the human histone deacetylase familyQ24294822
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancerQ24308737
SUMOylation enhances DNA methyltransferase 1 activityQ24311725
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcriptionQ24312958
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1Q24336747
Mapping a dynamic innate immunity protein interaction network regulating type I interferon productionQ24337463
Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor.Q25256835
Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancerQ26827297
The role of histone demethylases in cancer therapyQ26864687
Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous systemQ27659896
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stabilityQ27666366
Cancer statistics, 2014Q27861018
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapyQ28235397
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biologyQ28269080
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrenceQ28277232
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylationQ28304726
The vitamin D receptor (VDR) gene polymorphisms in Turkish brain cancer patientsQ28382894
The mutational landscape of lethal castration-resistant prostate cancerQ29614634
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and diseaseQ29617086
Vitamin D receptor regulates intestinal proteins involved in cell proliferation, migration and stress responseQ30317491
Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitorQ30414643
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.Q30668571
Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivoQ33637048
A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3.Q33832689
Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3.Q40052462
Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activityQ40439686
Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitorsQ40540512
Current understanding of the molecular actions of vitamin D.Q40838113
Metastatic prostate cancer in a transgenic mouseQ41167965
The vitamin D hormone and its nuclear receptor: molecular actions and disease states.Q41649611
Characterization of Vitamin D insensitive prostate cancer cellsQ42269190
Vitamin D receptor binds to the ε germline gene promoter and exhibits transrepressive activityQ42868319
Vitamin D receptor gene polymorphisms and breast cancer riskQ45029601
LSD1 demethylates histone and non-histone proteins.Q46035931
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.Q64996606
Phosphorylation of human DNMT1: implication of cyclin-dependent kinasesQ84084177
Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer.Q33999763
Elevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion.Q34094960
Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stabilityQ34178072
Prostate cancer in a transgenic mouseQ34444393
The Molecular Taxonomy of Primary Prostate CancerQ34674332
Androgen Receptor regulation of Vitamin D receptor in response of castration-resistant prostate cancer cells to 1α-Hydroxyvitamin D5 - a calcitriol analogQ34943321
The protective role of vitamin d signaling in non-melanoma skin cancerQ35033717
Active repression by unliganded retinoid receptors in development: less is sometimes moreQ35116527
Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitorsQ35133399
Association of vitamin D receptor gene polymorphism with the urine calcium level in nephrolithiasis patientsQ35202376
Regulation of mouse Cyp24a1 expression via promoter-proximal and downstream-distal enhancers highlights new concepts of 1,25-dihydroxyvitamin D(3) actionQ35858723
Controlling nuclear receptors: the circular logic of cofactor cyclesQ36163600
Epigenetic corruption of VDR signalling in malignancyQ36555803
The impact of chromatin organization of vitamin D target genes.Q36555818
Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patternsQ36587617
Identification of a 1,25-dihydroxyvitamin D3-response element in the 5'-flanking region of the rat calbindin D-9k geneQ36789946
Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granulesQ36995427
Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1alpha,25-dihydroxyvitamin D3.Q37134448
Gene regulatory scenarios of primary 1,25-dihydroxyvitamin d3 target genes in a human myeloid leukemia cell lineQ37420569
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D.Q37958494
Histone lysine demethylases as targets for anticancer therapyQ38162717
Regulation of protein stability of DNA methyltransferase 1 by post-translational modificationsQ38175783
Vitamin D receptor overexpression in osteoblasts and osteocytes prevents bone loss during vitamin D-deficiency.Q38179164
Vitamin D and gene networks in human osteoblasts.Q38208297
Insulin-like growth factor binding protein-3 mediates 1 alpha,25-dihydroxyvitamin d(3) growth inhibition in the LNCaP prostate cancer cell line through p21/WAF1.Q38303196
c-myc intron element-binding proteins are required for 1, 25-dihydroxyvitamin D3 regulation of c-myc during HL-60 cell differentiation and the involvement of HOXB4.Q38326977
Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cellsQ38338010
The effects of 1alpha,25-dihydroxyvitamin D3 on the expression of DNA replication genesQ38345301
Targeting Histone Demethylases: A New Avenue for the Fight against CancerQ38459037
Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.Q38931537
Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cellsQ39054183
DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cellsQ39369871
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancersQ39723644
Treatment of K562 cells with 1,25-dihydroxyvitamin D3 induces distinct alterations in the expression of apoptosis-related genes BCL2, BAX, BCLXL, and p21.Q39846248
P921main subjectvitamin DQ175621
P304page(s)82
P577publication date2017-08-11
P1433published inClinical EpigeneticsQ18620113
P1476titleLSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer
P478volume9

Reverse relations

cites work (P2860)
Q54974720Epigenetic Regulation in Prostate Cancer Progression.
Q90080042Epigenetic Regulation of p21cip1/waf1 in Human Cancer
Q64089048The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes: Implications for Bone Metabolism
Q55468580Without 1α-hydroxylation, the gene expression profile of 25(OH)D3 treatment overlaps deeply with that of 1,25(OH)2D3 in prostate cancer cells.

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