Mechanisms of tumour resistance against chemotherapeutic agents in veterinary oncology

scientific article published on 6 July 2015

Mechanisms of tumour resistance against chemotherapeutic agents in veterinary oncology is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.TVJL.2015.06.015
P698PubMed publication ID26526523

P50authorRobert KlopfleischQ42203407
P2093author name stringB Kohn
A D Gruber
P2860cites workThe Hallmarks of CancerQ221226
Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cellsQ46817260
Quantitative analysis of mRNA for 10 different drug resistance factors in dogs with lymphoma.Q51773044
Widespread mismatch repair protein expression in canine cutaneous mast cell tumors.Q51786404
Evaluation of DNA methylation profiles of the CpG island of the ABCB1 gene in dogs with lymphoma.Q54193708
Prognostic significance of the expression levels of the p16, p15, and p14 genes in dogs with high-grade lymphoma.Q54230653
Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.Q54377554
Expression of ABC-transport proteins in canine mammary cancer: consequences for chemotherapy.Q54465322
Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer.Q55043363
Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogsQ57441372
Expression of a multidrug resistance gene in human cancersQ69366790
BRCA1 expression in canine mammary dysplasias and tumours: relationship with prognostic variablesQ73592738
Metallothionein expression in canine and feline mammary and melanotic tumoursQ74571516
Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphomaQ80557198
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenanceQ81308407
Metallothionein expression in benign and malignant canine mammary gland tumoursQ81483091
Widespread mismatch repair expression in feline small intestinal lymphomasQ82036834
Immunohistochemical detection of proteins associated with multidrug resistance to anti-cancer drugs in canine and feline primary pulmonary carcinomaQ82568439
Evaluation of P-glycoprotein expression in feline lymphoma and correlation with clinical outcomeQ83262134
Favorable effect of priming with granulocyte colony-stimulating factor in remission induction of acute myeloid leukemia restricted to dose escalation of cytarabineQ83668556
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signalingQ24304423
Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemiaQ24310753
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemiaQ24313505
Reaction of human metallothionein-3 with cisplatin and transplatinQ24338731
Chromatin: constructing the big pictureQ24632812
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenograftsQ24642170
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatmentQ24656967
Cancer stem cells--important players in tumor therapy resistanceQ26823015
Trials with 'epigenetic' drugs: an updateQ27000542
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyQ27860519
Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseQ27860541
Resistance to therapy caused by intragenic deletion in BRCA2Q28268169
The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumorsQ28279114
Exploring the role of cancer stem cells in radioresistanceQ28282037
The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomasQ28299374
Molecular carcinogenesis of canine mammary tumors: news from an old diseaseQ28300581
Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomasQ28307817
DNA repair deficiency as a susceptibility marker for spontaneous lymphoma in golden retriever dogs: a case-control studyQ28534784
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivoQ28572747
Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATMQ28611443
Cancer drug resistance: an evolving paradigmQ29616694
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2Q33521938
Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivoQ33720256
Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia®) in canine mast cell tumor.Q33726782
Long term cultured HL-60 cells are intrinsically resistant to Ara-C through high CDA activityQ33915063
Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors?Q34010120
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemiaQ34157874
Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genesQ34322014
Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell linesQ34407959
Drug resistance in cancer: an overview.Q34437369
The evolving cancer stem cell paradigm: implications in veterinary oncologyQ34460364
Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemiaQ34536382
Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells.Q34774983
Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistanceQ34996744
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networksQ35001086
DNA damage response and DNA repair - dog as a model?Q35123713
IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cellsQ35141573
Molecular mechanisms of resistance and toxicity associated with platinating agentsQ35758048
Tumoral drug metabolism: overview and its implications for cancer therapyQ35996426
Breast cancer resistance protein (ABCG2) determines distribution of genistein phase II metabolites: reevaluation of the roles of ABCG2 in the disposition of genisteinQ36296183
Subcutaneous 5-azacitidine treatment of naturally occurring canine urothelial carcinoma: a novel epigenetic approach to human urothelial carcinoma drug developmentQ36430196
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistanceQ36597042
Mechanisms of chemoresistance to alkylating agents in malignant gliomaQ36726010
Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathwayQ36967531
5-Fluorouracil: mechanisms of resistance and reversal strategiesQ37270356
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibitionQ37670967
A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.Q37711644
Targeting Wnt signaling: can we safely eradicate cancer stem cells?Q37763415
Towards novel paradigms for cancer therapy.Q37799251
Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expressionQ37849716
Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cellsQ37878174
Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistanceQ37987293
DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets.Q38025707
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistanceQ38037329
Kinase dysfunction and kinase inhibitorsQ38075152
Camptothecin resistance in cancer: insights into the molecular mechanisms of a DNA-damaging drugQ38083793
ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development.Q38107993
Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics.Q38187646
Poised epigenetic states and acquired drug resistance in cancerQ38254072
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decadeQ38305824
Personalised medicine in veterinary oncology: one to cure just one.Q38340264
Clinicopathologic significance of histologic grade, pgp, and p53 expression in canine lymphomaQ38397528
The regulation of the expression of ABCG2 gene through mitogen-activated protein kinase pathways in canine lymphoid tumor cell linesQ38696906
Expression of stem cell marker and receptor kinase genes in glioblastoma tissue quantified by real-time RT-PCRQ38752082
Molecular changes associated with the development of resistance to imatinib in an imatinib-sensitive canine neoplastic mast cell line carrying a KIT c.1523A>T mutationQ38909315
Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell linesQ38915906
Multi-drug resistance in a canine lymphoid cell line due to increased P-glycoprotein expression, a potential model for drug-resistant canine lymphomaQ38979920
Antitumour effect and modulation of expression of the ABCB1 gene by perifosine in canine lymphoid tumour cell linesQ38989693
Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cellsQ38996410
Canine mammary carcinoma cell line are resistant to chemosensitizers: verapamil and cyclosporin A.Q39005191
Epigenetic regulation of the ABCB1 gene in drug-sensitive and drug-resistant lymphoid tumour cell lines obtained from canine patientsQ39044254
Expression of asparagine synthetase predicts in vitro response to L-asparaginase in canine lymphoid cell linesQ39096462
CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancerQ39123011
Masitinib reverses doxorubicin resistance in canine lymphoid cells by inhibiting the function of P-glycoproteinQ39202090
Specific elimination of CD133+ tumor cells with targeted oncolytic measles virusQ39215473
Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cellsQ39264734
Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance.Q39368008
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequencyQ39815141
Expression of Multidrug Resistance-Associated P-Glycoprotein in Feline TumoursQ39832673
Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78.Q39839037
Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells.Q39996225
Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cellsQ39996238
ERK1/2 is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatin-mediated apoptosisQ40131845
Expression of the MDR1 gene and P-glycoprotein in canine mast cell tumor cell linesQ40162939
Molecular analysis of multidrug resistance in feline lymphoma cellsQ40856325
A longitudinal study of ABC transporter expression in canine multicentric lymphomaQ41727264
Decreased mitochondrial priming determines chemoresistance of colon cancer stem cellsQ42040567
Targeting colorectal cancer stem cells with inducible caspase-9Q42116107
Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell deathQ42441668
Prognostic utility of apoptosis index, Ki-67 and survivin expression in dogs with nasal carcinoma treated with orthovoltage radiation therapyQ43074794
Efficacy of a continuous, multiagent chemotherapeutic protocol versus a short-term single-agent protocol in dogs with lymphomaQ44701589
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signalingQ45065876
Increased expression of the antiapoptotic protein MCL1 in canine mast cell tumorsQ45146096
Comparative analysis of survivin expression in untreated and relapsed canine lymphoma.Q46469047
Xenobiotic-metabolizing enzymes in canine mammary tumoursQ46598355
P921main subjectchemotherapyQ974135
P304page(s)63-72
P577publication date2015-07-06
P1433published inThe Veterinary JournalQ15752615
P1476titleMechanisms of tumour resistance against chemotherapeutic agents in veterinary oncology
P478volume207

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cites work (P2860)
Q36264911Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy
Q90303961Characterization of six canine prostate adenocarcinoma and three transitional cell carcinoma cell lines derived from primary tumor tissues as well as metastasis
Q36926967Heterochromatin Protein 1 Binding Protein 3 Expression as a Candidate Marker of Intrinsic 5-Fluorouracil Resistance
Q38828353Mechanisms of tumor cell resistance to the current targeted-therapy agents.
Q42658274The Different Mechanisms of Cancer Drug Resistance: A Brief Review.

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