Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows

scientific article published on 09 August 2017

Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPREGU.00197.2017
P932PMC publication ID5792149
P698PubMed publication ID28794103

P2093author name stringJames W Perfield
Sarah L Giesy
Yves R Boisclair
Katie M Schoenberg
Luciano S Caixeta
Anthony Butterfield
Christopher S Krumm
Donald Clarence Beitz
P2860cites workHuman HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell lineQ24608087
BetaKlotho is required for metabolic activity of fibroblast growth factor 21Q24681531
Regulation of organic nutrient metabolism during transition from late pregnancy to early lactationQ40959412
FGF-21/FGF-21 receptor interaction and activation is determined by betaKlothoQ42819634
Chronic metabolic responses of postpartal dairy cows to subcutaneous glucagon injections, oral glycerol, or bothQ42959889
Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin.Q43083741
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance.Q43787421
Production Responses of Dairy Cows to Dietary Supplementation with Conjugated Linoleic Acid (CLA) During the Transition Period and Early LactationQ44639965
Performance and metabolic and endocrine changes with emphasis on glucose metabolism in high-yielding dairy cows with high and low fat content in liver after calvingQ46078088
Acute metabolic responses of postpartal dairy cows to subcutaneous glucagon injections, oral glycerol, or both.Q46395365
The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.Q46445480
Influence of growth hormone on circulating fibroblast growth factor 21 levels in humansQ48026201
Dry period plane of energy: Effects on glucose tolerance in transition dairy cows.Q53262343
Lipolysis in subcutaneous and perirenal adipose tissue from sheep and dairy steersQ67586577
Response of plasma leptin concentration to jugular infusion of glucose or lipid is dependent on the stage of lactation of Holstein cowsQ79339508
Prevention of fatty liver in transition dairy cows by subcutaneous injections of glucagonQ83136708
Prepartum dietary energy intake affects metabolism and health during the periparturient period in primiparous and multiparous Holstein cowsQ83455555
Roles of FGF Signals in Heart Development, Health, and DiseaseQ28072691
Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?Q28571194
Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytesQ28571616
The glucagon receptor is required for the adaptive metabolic response to fastingQ28594780
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21Q29615209
Thyroid hormone regulation of metabolismQ33707954
Adaptations of glucose metabolism during pregnancy and lactationQ33959384
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosisQ34019712
Plasma FGF21 is elevated by the intense lipid mobilization of lactationQ34223326
Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytesQ35266423
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient dietsQ36061647
Lipid metabolism during lactation: a review of adipose tissue-liver interactions and the development of fatty liverQ36285506
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasisQ36746670
Fibroblast growth factor 21 mediates specific glucagon actionsQ36796145
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver diseaseQ36889026
CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysisQ37005595
A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.Q37571422
Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21.Q37594100
Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and diseaseQ37781747
Hormone-like fibroblast growth factors and metabolic regulationQ37866879
The role of hepatokines in metabolismQ38075770
Insulin resistance in dairy cowsQ38117866
PPARalpha is a key regulator of hepatic FGF21.Q38300403
Systemic Nutrient and Stress Signaling via Myokines and MyometabolitesQ38623031
Understanding the Physiology of FGF21.Q38665376
FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent MechanismsQ38852382
The New Biology and Pharmacology of Glucagon.Q38919742
Adipose crosstalk with other cell types in health and diseaseQ39256570
Increased plasma leptin attenuates adaptive metabolism in early lactating dairy cows.Q39936768
P921main subjectfatty acidQ61476
glucagonQ28163629
P304page(s)ajpregu.00197.2017
P577publication date2017-08-09
P1433published inAmerican Journal of Physiology - Regulatory, Integrative and Comparative PhysiologyQ2201819
P1476titleEffect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows