Pathogenesis of thyroid eye disease: review and update on molecular mechanisms.

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Pathogenesis of thyroid eye disease: review and update on molecular mechanisms. is …
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scholarly articleQ13442814

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P356DOI10.1136/BJOPHTHALMOL-2015-307399
P698PubMed publication ID26567024
P5875ResearchGate publication ID283811908

P50authorJwu Jin KhongQ50797300
Jamie E CraigQ82048083
P2093author name stringPeter R Ebeling
Dinesh Selva
Alan A McNab
P2860cites workGene expression profiling of orbital adipose tissue from patients with Graves' ophthalmopathy: a potential role for secreted frizzled-related protein-1 in orbital adipogenesisQ24301803
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Peroxisome proliferator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhesion to orbital fibroblastsQ34998187
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Thy-1 Expression in Human Fibroblast Subsets Defines Myofibroblastic or Lipofibroblastic PhenotypesQ35792099
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Clinical review: Clinical utility of TSH receptor antibodiesQ36885833
Pathogenesis of Graves' ophthalmopathy: the role of autoantibodiesQ36970632
Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves' orbitopathy.Q37017174
Immune mechanisms in thyroid eye disease.Q37254482
Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtypeQ37296579
The type 1 insulin-like growth factor receptor pathwayQ37300867
Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1.Q37363607
Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease.Q37417167
A modified ELISA accurately measures secretion of high molecular weight hyaluronan (HA) by Graves' disease orbital cellsQ37479329
Evidence for enhanced adipogenesis in the orbits of patients with Graves' ophthalmopathyQ37515485
Epidemiology of Graves' orbitopathy (GO) and relationship with thyroid disease.Q38013212
Immunotherapy for Graves' ophthalmopathyQ38238204
Transcriptome-level microarray expression profiling implicates IGF-1 and Wnt signalling dysregulation in the pathogenesis of thyroid-associated orbitopathyQ38325670
Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction.Q38351966
Adalimumab as steroid-sparing treatment of inflammatory-stage thyroid eye diseaseQ39167512
Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathyQ40893670
Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitriteQ40917292
Analysis of extraocular muscle-infiltrating T cells in thyroid-associated ophthalmopathy (TAO).Q41096678
The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytesQ42801077
Increased oxidative DNA damage, lipid peroxidation, and reactive oxygen species in cultured orbital fibroblasts from patients with Graves' ophthalmopathy: evidence that oxidative stress has a role in this disorderQ43124440
A novel thyroid stimulating immunoglobulin bioassay is a functional indicator of activity and severity of Graves' orbitopathy.Q43125924
Clinical relevance of thyroid-stimulating autoantibodies in pediatric graves' disease-a multicenter studyQ43626915
Interleukin-6 stimulates thyrotropin receptor expression in human orbital preadipocyte fibroblasts from patients with Graves' ophthalmopathyQ43804248
Igs from patients with Graves' disease induce the expression of T cell chemoattractants in their fibroblastsQ43845891
Fibroblast subsets in the human orbit: Thy-1+ and Thy-1- subpopulations exhibit distinct phenotypesQ43867818
Cutting edge: retrobulbar inflammation, adipogenesis, and acute orbital congestion in a preclinical female mouse model of Graves' orbitopathy induced by thyrotropin receptor plasmid-in vivo electroporationQ44356261
Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditisQ44375662
Adipose thyrotrophin receptor expression is elevated in Graves' and thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivoQ44468299
Peripheral parameters of oxidative stress in Graves' disease: the effects of methimazole and 131 iodine treatmentsQ44550002
Relative overexpression of macrophage-derived cytokines in orbital adipose tissue from patients with graves' ophthalmopathyQ44582494
Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor.Q45096631
Reevaluating thyrotropin receptor-induced mouse models of graves' disease and ophthalmopathy.Q45149782
Oxidative stress peripheral parameters in Graves' disease: the effect of methimazole treatment in patients with and without infiltrative ophthalmopathyQ45192863
Potential utility of rituximab for Graves' orbitopathyQ45719549
IL-1 beta induces IL-6 expression in human orbital fibroblasts: identification of an anatomic-site specific phenotypic attribute relevant to thyroid-associated ophthalmopathy.Q45981776
Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the insulin-like growth factor I receptor pathwayQ46107628
Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathyQ46113795
Oxidative stress in patients with Graves' ophthalmopathy: relationship between oxidative DNA damage and clinical evolution.Q46320003
Oxidative stress and antioxidant activity in orbital fibroadipose tissue in Graves' ophthalmopathyQ46527993
Autoantibodies to the IGF1 receptor in Graves' orbitopathyQ46825815
Complete inhibition of rhTSH-, Graves' disease IgG-, and M22-induced cAMP production in differentiated orbital fibroblasts by a low-molecular-weight TSHR antagonistQ47321532
Analysis of orbital T cells in thyroid-associated ophthalmopathyQ47901537
Prevalence and natural history of Graves' orbitopathy in a large series of patients with newly diagnosed graves' hyperthyroidism seen at a single center.Q51258119
Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy.Q53092953
Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy.Q53611171
Smoking and Risk of Graves' DiseaseQ54186495
Insulin-like growth factor 1 promotes the proliferation and adipogenesis of orbital adipose-derived stromal cells in thyroid-associated ophthalmopathy.Q54280456
The expression of intercellular adhesion molecule-1 induced by CD40-CD40L ligand signaling in orbital fibroblasts in patients with Graves' ophthalmopathy.Q54444573
Occurrence of Ophthalmopathy after Treatment for Graves' HyperthyroidismQ57482592
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
P304page(s)142-150
P577publication date2015-11-13
P1433published inBritish Journal of OphthalmologyQ13443571
P1476titlePathogenesis of thyroid eye disease: review and update on molecular mechanisms
P478volume100

Reverse relations

cites work (P2860)
Q92994581A Novel Method of CT Exophthalmometry in Patients With Thyroid Eye Disease
Q47299466A genome-wide DNA methylation analysis in peripheral blood from patients identifies risk loci associated with Graves' orbitopathy
Q64285170Bioinformatic Analysis Identifies Potentially Key Differentially Expressed Genes and Pathways in Orbital Adipose Tissues of Patients with Thyroid Eye Disease
Q53065936Choroidal Thickness in Patients with Graves' Ophthalmopathy.
Q37010019Cigarette Smoke Extract-Induced Oxidative Stress and Fibrosis-Related Genes Expression in Orbital Fibroblasts from Patients with Graves' Ophthalmopathy
Q63387333Clinical pathophysiology of thyroid eye disease: The Cone Model
Q55717336Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy.
Q40095263Dysthyroid optic neuropathy: update on pathogenesis, diagnosis, and management
Q92088550Efficacy and safety of tripterygium glycosides for Graves ophthalmopathy: A systematic review and meta-analysis
Q94474152Enhanced orbital adipogenesis in a mouse model of T-cell-mediated autoimmunity, zymosan A-treated SKG mice: Implications for Graves' ophthalmopathy
Q54960708Essential role of connective tissue growth factor (CTGF) in transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from Graves' orbital fibroblasts.
Q90185484Immunohistochemical analysis of human orbital tissue in Graves' orbitopathy
Q58767088Long-term effect of triamcinolone acetonide in the treatment of upper lid retraction with thyroid associated ophthalmopathy
Q47323119Measurement of Orbital Biomechanical Properties in Patients with Thyroid Orbitopathy Using the Dynamic Scheimpflug Analyzer (Corvis ST).
Q99579021MicroRNA-146a downregulates the production of hyaluronic acid and collagen I in Graves' ophthalmopathy orbital fibroblasts
Q38680245Piezosurgery in modified pterional orbital decompression surgery in Graves' disease
Q47121440RNA-Sequencing Gene Expression Profiling of Orbital Adipose-Derived Stem Cell Population Implicate HOX Genes and WNT Signaling Dysregulation in the Pathogenesis of Thyroid-Associated Orbitopathy
Q38986592Roles of IL-6 in Ocular Inflammation: A Review
Q92157970The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy
Q55140443Thyroid-Associated Orbitopathy and Biomarkers: Where We Are and What We Can Hope for the Future.
Q88139077[Calculation of orbital fat volumes for determining treatment timing for thyroid- associated ophthalmopathy]

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