Advances in immunopathogenesis of macrophage activation syndrome during rheumatic inflammatory diseases: toward new therapeutic targets?

scientific article published on 24 August 2017

Advances in immunopathogenesis of macrophage activation syndrome during rheumatic inflammatory diseases: toward new therapeutic targets? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/1744666X.2017.1372194
P698PubMed publication ID28837367

P50authorVasiliki LiakouliQ55273178
Giuliana GugginoQ56810321
Piero RuscittiQ88511212
Onorina BerardicurtiQ95331019
Paola Di BenedettoQ40484648
Roberto GiacomelliQ42416418
P2093author name stringFrancesco Carubbi
Giovanni Triolo
Francesco Ciccia
Paola Cipriani
P2860cites workFerritin for the clinicianQ24642942
Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndromeQ28239135
Chimeric antigen receptor T cells for sustained remissions in leukemiaQ29617588
Inflammation meets cancer, with NF-κB as the matchmakerQ29620242
IL-1β at the crossroad between rheumatoid arthritis and type 2 diabetes: may we kill two birds with one stone?Q30251741
Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.Q30626213
Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 productionQ30989272
Reactive haemophagocytic syndrome in adult-onset Still's disease: a report of six patients and a review of the literatureQ33370577
Life-threatening complications of adult-onset Still's diseaseQ33412732
Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features, predictive factors, and prognosis in 21 patientsQ33420069
Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosisQ33429617
Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis: A case report treated with high doses (8 mg/kg/d) of anakinraQ33817997
Perforin gene defects in familial hemophagocytic lymphohistiocytosis.Q33882431
Regulation of ferritin genes and proteinQ34126332
The hyperferritinemic syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndromeQ34966670
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.Q35015661
Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritisQ35041117
Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosisQ35064189
Serum neopterin levels as a diagnostic marker of hemophagocytic lymphohistiocytosis syndromeQ35066319
Methotrexate in rheumatoid arthritis: optimizing therapy among different formulations. Current and emerging paradigms.Q35115790
Perforin is a critical physiologic regulator of T-cell activationQ35125914
The role of IL-1β in the bone loss during rheumatic diseases.Q35540844
Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH.Q35585941
Efficacy of inhibition of IL-1 in patients with rheumatoid arthritis and type 2 diabetes mellitus: two case reports and review of the literatureQ35687532
Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndromeQ35847631
Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasisQ36015036
Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient miceQ36042041
Adult-onset Still's disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centersQ36208563
Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.Q44318263
Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosisQ45400777
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway.Q46645329
Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndromeQ47368371
Novel NLRC4 Mutation Causes a Syndrome of Perinatal Autoinflammation With Hemophagocytic Lymphohistiocytosis, Hepatosplenomegaly, Fetal Thrombotic Vasculopathy, and Congenital Anemia and Ascites.Q51061979
Benefit and a possible risk of tocilizumab therapy for adult-onset Still’s disease accompanied by macrophage-activation syndromeQ51545663
Increased serum monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, and interleukin-8 concentrations in hemophagocytic lymphohistiocytosis.Q51952551
Alleviating the storm: ruxolitinib in HLH.Q53132444
Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice.Q53916622
Amplification of the response to Toll-like receptor ligands by prolonged exposure to interleukin-6 in mice: implication for the pathogenesis of macrophage activation syndrome.Q54337698
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosisQ36403570
Tuberculosis-associated haemophagocytic syndrome.Q36514429
A Heterozygous RAB27A Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis.Q36655896
Infections associated with haemophagocytic syndrome.Q37018227
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cellsQ37240288
The costimulatory role of TIM moleculesQ37474954
Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome.Q37589316
Viral infections associated with haemophagocytic syndrome.Q37686403
Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III TrialQ37735696
Adult haemophagocytic syndromeQ38167486
Methotrexate: an old new drug in autoimmune disease.Q38253237
Increased level of H-ferritin and its imbalance with L-ferritin, in bone marrow and liver of patients with adult onset Still's disease, developing macrophage activation syndrome, correlate with the severity of the disease.Q38323485
Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis under Treatment with Tocilizumab.Q38356706
The role and therapeutic targeting of IL-6 in rheumatoid arthritis.Q38685086
Response to Interleukin-1 Inhibitors in 140 Italian Patients with Adult-Onset Still's Disease: A Multicentre Retrospective Observational StudyQ38703626
JAK inhibition in inflammatory bowel diseaseQ38761142
Macrophage activation syndrome in the era of biologic therapy.Q38786756
Baricitinib for the treatment of rheumatoid arthritisQ38840787
Progress in understanding the safety and efficacy of Janus kinase inhibitors for treatment of rheumatoid arthritisQ38851433
Prognostic factors of macrophage activation syndrome, at the time of diagnosis, in adult patients affected by autoimmune disease: Analysis of 41 cases collected in 2 rheumatologic centers.Q39355242
Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.Q39385892
H-ferritin and CD68(+) /H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease.Q39673488
Adult-onset Still's disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patientsQ39748097
Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis.Q39761819
Application of the 2016 EULAR/ACR/PRINTO Classification Criteria for Macrophage Activation Syndrome in Patients with Adult-onset Still Disease.Q40060914
Tocilizumab for the treatment of adult-onset Still's disease: results from a case series.Q40235629
Treatment of hemophagocytic lymphohistiocytosis with alemtuzumab in systemic lupus erythematosusQ40293009
The CD68(+)/H-ferritin(+) cells colonize the lymph nodes of the patients with adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue: correlation with disease severity and implication for pQ40352271
Alemtuzumab as a bridge to allogeneic SCT in atypical hemophagocytic lymphohistiocytosisQ40360876
Biologic therapies and infections in the daily practice of three Italian rheumatologic units: a prospective, observational study.Q40484547
Success with infliximab in treating refractory hemophagocytic lymphohistiocytosisQ40490433
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorderQ40536555
Assessment of the HScore for reactive haemophagocytic syndrome in patients with rheumatic diseases.Q40630673
Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With CanakinumabQ41029387
Prognostic factors of early death in a cohort of 162 adult haemophagocytic syndrome: impact of triggering disease and early treatment with etoposideQ42197904
Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab.Q42260141
Plasma exchange, methylprednisolone, IV immune globulin, and now anakinra support continued PICU equipoise in management of hyperferritinemia-associated sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome/secondary hemophagocytQ42375787
P433issue11
P921main subjectactivation syndromeQ4677466
macrophage activation syndromeQ6725504
P304page(s)1041-1047
P577publication date2017-09-01
P1433published inExpert Review of Clinical ImmunologyQ15733763
P1476titleAdvances in immunopathogenesis of macrophage activation syndrome during rheumatic inflammatory diseases: toward new therapeutic targets?
P478volume13

Reverse relations

cites work (P2860)
Q47727637H-ferritin and proinflammatory cytokines are increased in the bone marrow of patients affected by macrophage activation syndrome.
Q94590921Impact of COVID-19 pandemic on SLE: beyond the risk of infection
Q64235820Managing Adult-onset Still's disease: The effectiveness of high-dosage of corticosteroids as first-line treatment in inducing the clinical remission. Results from an observational study
Q97653199Pro-inflammatory properties of H-ferritin on human macrophages, ex vivo and in vitro observations
Q96647317Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm

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