STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential.

scientific article published on 25 November 2015

STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/08830185.2015.1087519
P698PubMed publication ID26606328

P50authorBluyssen HQ72285833
Joanna WesołyQ95835476
P2093author name stringStefan Chmielewski
Anna Piaszyk-Borychowska
P2860cites workDamage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension.Q43797072
Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantationQ45153732
Pravastatin attenuates interferon-gamma action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E-knockout miceQ46238735
Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndromeQ46481417
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High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice.Q50554632
Modulation of vascular smooth muscle cell phenotype by STAT-1 and STAT-3.Q51519556
SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.Q54367716
Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.Q54596085
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Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic MiceQ58149069
Interferon-γ elicits arteriosclerosis in the absence of leukocytesQ59064332
Projections of global mortality and burden of disease from 2002 to 2030Q21144688
Structural bases of unphosphorylated STAT1 association and receptor bindingQ24298555
ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cellsQ24672345
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The influence of innate and adaptive immune responses on atherosclerosisQ27000370
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsQ27860900
Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosomeQ28138857
Mechanisms of type-I- and type-II-interferon-mediated signallingQ28247893
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variantsQ28290376
IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathwaysQ28297876
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexesQ28508859
Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validationQ28543632
Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activationQ28576748
Compensatory dendritic cell development mediated by BATF-IRF interactionsQ28586184
BATF-JUN is critical for IRF4-mediated transcription in T cellsQ28590152
Metabolic endotoxemia initiates obesity and insulin resistanceQ29547720
Stats: transcriptional control and biological impactQ29547776
The family of five: TIR-domain-containing adaptors in Toll-like receptor signallingQ29615457
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Phenotypic modulation of macrophages in response to plaque lipidsQ30413906
Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.Q30481584
Data mining of atherosclerotic plaque transcriptomes predicts STAT1-dependent inflammatory signal integration in vascular disease.Q30848049
Inducible nitric oxide synthase deficiency does not affect the susceptibility of mice to atherosclerosis but increases collagen content in lesionsQ32061834
NO-independent regulatory site on soluble guanylate cyclaseQ32165040
AP-1 and STAT-1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allograftsQ33338764
Therapeutic modulators of STAT signalling for human diseasesQ33684732
Loss of STAT1 is associated with increased aortic rupture in an experimental model of aortic dissection and aneurysm formationQ33761769
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responsesQ33819043
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycleQ33932725
Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort studyQ33932928
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cellsQ33935165
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein EQ33962949
Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cellsQ33967700
The immune system in atherosclerosisQ34164644
Macrophages in atherosclerosis: a dynamic balance.Q34368005
A20 regulates atherogenic interferon (IFN)-γ signaling in vascular cells by modulating basal IFNβ levels.Q34467421
Inflammation, immunity, and hypertensionQ34528283
Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient miceQ34555906
Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.Q34629986
STAT1 signaling is not regulated by a phosphorylation-acetylation switchQ35096677
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasisQ35144610
Comparative screening and validation as a novel tool to identify STAT-specific inhibitorsQ35237252
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaquesQ35250952
STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosisQ35493777
The interferon in TLR signaling: more than just antiviralQ35557279
Role of endothelial dysfunction in atherosclerosisQ35806066
Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages.Q35847894
Regulation of STAT signaling by acetylationQ35998100
The yin and yang of type I interferon activity in bacterial infectionQ36234715
Immune cell-specific amplification of interferon signaling by the IRF-4/8-PU.1 complexQ36351968
The immune response in atherosclerosis: a double-edged swordQ36508676
Signal integration between IFNgamma and TLR signalling pathways in macrophagesQ36571648
Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertensionQ36660171
Endotoxemia is related to systemic inflammation and atherosclerosis in peritoneal dialysis patientsQ36666840
Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activationQ36821740
STAT1 as a central mediator of IFNγ and TLR4 signal integration in vascular dysfunctionQ36895444
STAT transcription in the ischemic heartQ36895468
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein EQ36986664
Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanismsQ37071983
New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe.Q37130222
Biology and significance of the JAK/STAT signalling pathwaysQ37146441
Identification of a dendritic cell receptor that couples sensing of necrosis to immunityQ37164859
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantationQ37246506
Inteferons pen the JAK-STAT pathwayQ37259013
Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B geneQ37284465
The role of adaptive T cell immunity in atherosclerosisQ37339539
IFN-gamma potentiates atherosclerosis in ApoE knock-out miceQ37368296
Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse heartsQ37370287
Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and ruptureQ37394705
Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseasesQ37414046
Interferon regulatory factor 8 modulates phenotypic switching of smooth muscle cells by regulating the activity of myocardin.Q37546984
IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signallingQ37594217
Phosphorylation-acetylation switch in the regulation of STAT1 signalingQ37625138
The roles of Toll-like receptors in atherosclerosis.Q37726729
Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation.Q37740254
The expression and functions of toll-like receptors in atherosclerosisQ37774869
The JAK-STAT pathway at twentyQ38004201
The HAT/HDAC interplay: multilevel control of STAT signalingQ38044539
Recent advances in the role of immunity in atherosclerosisQ38169131
Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cellsQ38340967
STATs dimerize in the absence of phosphorylationQ38353169
Oncotype DX(®) colon cancer assay for prediction of recurrence risk in patients with stage II and III colon cancer: A review of the evidenceQ38377402
TLR4 antagonist reduces early-stage atherosclerosis in diabetic apolipoprotein E-deficient mice.Q39260793
STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion.Q39586956
Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion developmentQ40126964
Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cellsQ40677997
Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domainQ41073163
HMEC-1: establishment of an immortalized human microvascular endothelial cell lineQ41592068
Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemiaQ41814200
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesityQ41834087
Interferon regulatory factors in heart: stress response beyond inflammationQ42637206
Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- miceQ42757050
CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosisQ43145952
Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cellsQ43260469
Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice.Q43653260
P433issue5
P921main subjectinflammationQ101991
cardiovascular diseaseQ389735
P304page(s)434-454
P577publication date2015-11-25
P1433published inInternational Reviews of ImmunologyQ6052764
P1476titleSTAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential
P478volume35

Reverse relations

cites work (P2860)
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Q92617376MiR-499a suppresses LPS-induced human vascular endothelial cell inflammatory response and apoptosis by regulating STAT1
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