T follicular helper cells in the generation of alloantibody and graft rejection

scientific article published on February 2016

T follicular helper cells in the generation of alloantibody and graft rejection is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1097/MOT.0000000000000260
P932PMC publication ID4702514
P698PubMed publication ID26727455

P2093author name stringMandy L Ford
I Raul Badell
P2860cites workICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6Q42136332
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.Q42261388
T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses?Q42598296
Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients.Q46007205
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.Q50499734
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.Q50736370
Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4.Q50762645
Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility.Q50903417
CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses.Q51013752
Monoclonal anti-interleukin-6 receptor antibody attenuates donor-specific antibody responses in a mouse model of allosensitization.Q51819771
T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reactionQ59071961
Anti-interleukin 6 receptor antibodies attenuate antibody recall responses in a mouse model of allosensitizationQ85686888
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin productionQ24676570
Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers.Q30582101
CD40-independent help by memory CD4 T cells induces pathogenic alloantibody but does not lead to long-lasting humoral immunityQ33603170
Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliteransQ33781179
Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.Q33891669
Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissueQ34030907
Crucial roles of interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunityQ34059261
Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infectionQ34239730
Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation moleculeQ34298838
Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.Q34464636
IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responsesQ34980154
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagementQ34985437
B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cellsQ35007635
The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.Q35021671
ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.Q35064898
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliteransQ35776453
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6Q35983849
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper functionQ36368291
Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccinationQ36752092
IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humansQ36797259
Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.Q37090620
Inadequate T follicular cell help impairs B cell immunity during HIV infection.Q37349638
Costimulation blockade alters germinal center responses and prevents antibody-mediated rejectionQ37700827
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responsesQ37718722
The good, the bad and the ugly - TFH cells in human health and diseaseQ38107389
Targeting co-stimulatory pathways: transplantation and autoimmunityQ38150101
T follicular helper cell differentiation, function, and roles in diseaseQ38264816
Follicular T helper cells and humoral reactivity in kidney transplant patientsQ38923388
Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotypeQ39180411
Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memoryQ39852423
Cutting edge: circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 productionQ41437027
P433issue1
P304page(s)1-6
P577publication date2016-02-01
P1433published inCurrent opinion in organ transplantationQ26842426
P1476titleT follicular helper cells in the generation of alloantibody and graft rejection
P478volume21

Reverse relations

cites work (P2860)
Q90220448Belatacept and CD28 Costimulation Blockade: Preventing and Reducing Alloantibodies over the Long Term
Q47704215Impact of immunosuppressive drugs on circulating Tfh cells in kidney transplant recipients: A pilot study
Q47248037Increased levels of CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells, and associated factors Bcl-6, CXCR5, IL-21 and IL-6 contribute to repeated implantation failure
Q45866611Regulatory B Cells Are Functionally Impaired in Patients Having Hemophilia A With Inhibitors.
Q48747887Selective CD28 Blockade Results in Superior Inhibition of Donor-Specific T Follicular Helper Cell and Antibody Responses Relative to CTLA4-Ig

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