Differential Regulation of Mas-Related G Protein-Coupled Receptor X2-Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas gingivalis Lipopolysaccharide

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Differential Regulation of Mas-Related G Protein-Coupled Receptor X2-Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas gingivalis Lipopolysaccharide is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.00246-17
P932PMC publication ID5607414
P698PubMed publication ID28694291

P2093author name stringDonguk Lee
Kathleen Boesze-Battaglia
Chizobam Idahosa
Hariharan Subramanian
Hydar Ali
Kshitij Gupta
Saptarshi Roy
Jonathan Korostoff
Anuradha Dhingra
P2860cites workMas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalizationQ24296488
Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactionsQ24310253
MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglionQ24314831
Porphyromonas gingivalis as a potential community activist for diseaseQ24616806
Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?Q24655246
LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cellsQ24675869
Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseasesQ28079028
The chemistry and biology of LL-37Q28265694
Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathwayQ28612022
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host responseQ28658053
Different activation signals induce distinct mast cell degranulation strategiesQ30827625
Hemin-dependent modulation of the lipid A structure of Porphyromonas gingivalis lipopolysaccharideQ33251439
Mast cells as sentinels of innate immunityQ33536530
Temperature-dependent modulation of Porphyromonas gingivalis lipid A structure and interaction with the innate host defenses.Q33789766
Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammationQ33882825
Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-κB signal transduction cascade and immuno-inflammatory response in human gingival fibroblastsQ34648053
Microbial shift and periodontitisQ34680857
Correlation of mast cells in periodontal diseasesQ34697727
PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cellsQ35008885
Mast cell secretory granules: armed for battleQ35182662
G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2.Q35202333
Overexpressions of hBD-2, hBD-3, and hCAP18/LL-37 in Gingiva of Diabetics with PeriodontitisQ35669150
Mast cells--a role in periodontal diseases?Q35772663
Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosisQ36147919
Innate immune signaling and Porphyromonas gingivalis-accelerated atherosclerosis.Q36376749
Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteriaQ36932099
β-Defensins activate human mast cells via Mas-related gene X2.Q36951709
Defensin participation in innate and adaptive immunityQ36990379
Antimicrobial peptides in periodontal innate defenseQ36991831
Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblastsQ37188987
Breaking bad: manipulation of the host response by Porphyromonas gingivalis.Q37586359
Periodontitis: a polymicrobial disruption of host homeostasisQ37761827
Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitisQ37780267
An update on innate defense molecules of human gingivaQ37866354
TLR signaling in mast cells: common and unique featuresQ38025397
Defensins and LL-37: a review of function in the gingival epitheliumQ38127778
Immune modulation by multifaceted cationic host defense (antimicrobial) peptidesQ38162670
Host defense peptides: front-line immunomodulatorsQ38239034
Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial propertiesQ38285790
Mast cells in human and experimental cardiometabolic diseasesQ38563903
Variants of Porphyromonas gingivalis lipopolysaccharide alter lipidation of autophagic protein, microtubule-associated protein 1 light chain 3, LC3.Q38733696
Modulation of host defense peptide-mediated human mast cell activation by LPS.Q38824103
Redefinition of the human mast cell transcriptome by deep-CAGE sequencingQ38967503
Quantification of tryptase-TIM-3 double-positive mast cells in human chronic periodontitisQ39084437
Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis.Q39570767
Mast Cells Contribute to Porphyromonas gingivalis-induced Bone LossQ39954935
Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4.Q40014914
Antagonistic lipopolysaccharides block E. coli lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding siteQ40184272
Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase.Q40479365
Quantification of mast cells in different stages of periodontal diseaseQ40609287
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI.Q40640528
Correlation of mast cells in different stages of human periodontal diseases: Pilot studyQ41188383
Lipopolysaccharide from Porphyromonas gingivalis stimulates rat mast cells to cysteinyl leukotriene generation and upregulates Toll-like receptor -2 and -4 expression.Q42860261
Microbial hijacking of complement-toll-like receptor crosstalkQ42911622
A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxisQ43969583
Noncanonical inflammasome activation by intracellular LPS independent of TLR4.Q44450840
Mast cells in human periodontal disease.Q44865940
Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodiesQ45024776
Quantification of mast cells in different stages of human periodontal disease.Q46572182
Gingival crevicular fluid levels of cathelicidin LL-37 and interleukin-18 in patients with chronic periodontitisQ47681957
Mast cell degranulation in human periodontitisQ50248557
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.Q50335870
Identification of periodontitis associated changes in the proteome of whole human saliva by mass spectrometric analysis.Q50888484
beta-Defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved.Q51972625
Mast cells are increased in the media of coronary lesions in patients with myocardial infarction and may favor atherosclerotic plaque instability.Q53082992
Influence of periodontal status and periodontopathogens on levels of oral human β-defensin-2 in saliva.Q54282627
Salivary levels of antibacterial peptide (LL-37/hCAP-18) and cotinine in patients with chronic periodontitis.Q54347097
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.Q55036173
Antimicrobial peptides human β-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeabilityQ57273088
Perivascular Mast Cells Promote Atherogenesis and Induce Plaque Destabilization in Apolipoprotein E–Deficient MiceQ63258329
Mast cells in innate immunityQ63353738
Crucial role for autophagy in degranulation of mast cellsQ63609781
Mast cells in periodontal diseaseQ67697510
Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte functionQ68155580
Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptorsQ80273382
Mast cells initiate early anti-Listeria host defencesQ80832242
Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticariaQ88130953
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
Porphyromonas gingivalisQ3214147
mast cellQ191989
lipopolysaccharideQ421804
P577publication date2017-09-20
P1433published inInfection and ImmunityQ6029193
P1476titleDifferential Regulation of Mas-Related G Protein-Coupled Receptor X2-Mediated Mast Cell Degranulation by Antimicrobial Host Defense Peptides and Porphyromonas gingivalis Lipopolysaccharide
P478volume85

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cites work (P2860)
Q93060094IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells-Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming
Q90079376Mast Cells as Potential Accelerators of Human Atherosclerosis-From Early to Late Lesions
Q88792599Naturally Occurring Missense MRGPRX2 Variants Display Loss of Function Phenotype for Mast Cell Degranulation in Response to Substance P, Hemokinin-1, Human β-Defensin-3, and Icatibant
Q64953708Small-Molecule Host-Defense Peptide Mimetic Antibacterial and Antifungal Agents Activate Human and Mouse Mast Cells via Mas-Related GPCRs.
Q64251899Superantigenic Activation of Human Cardiac Mast Cells
Q47151536Upregulation of Mas-related G Protein coupled receptor X2 in asthmatic lung mast cells and its activation by the novel neuropeptide hemokinin-1.

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