Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet

scientific article

Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/EPI.13833
P698PubMed publication ID28682459

P50authorSimon EatonQ87764213
P2093author name stringSimon J R Heales
Tricia Rutherford
Aziza Khabbush
Maura O'Donnell
Michael Orford
Yi-Chen Tsai
P2860cites workA novel brain-expressed protein related to carnitine palmitoyltransferase IQ28206878
Medium chain fatty acid metabolism and energy expenditure: obesity treatment implicationsQ28269412
The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cellsQ28304995
Enzymes of fatty acid beta-oxidation in developing brainQ28568761
The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysisQ29618429
Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolismQ34457970
Glucose and lactate metabolism during brain activationQ34464755
Seizure control by decanoic acid through direct AMPA receptor inhibitionQ34503147
Control of mitochondrial beta-oxidation fluxQ34508227
The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trialQ34775862
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasisQ35025300
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolismQ35540543
The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndromeQ36853449
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weightQ37465084
Sugar for the brain: the role of glucose in physiological and pathological brain functionQ37511476
Substituted 2-oxiranecarboxylic acids: a new group of candidate hypoglycaemic drugsQ38761800
Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing.Q41905287
Role of octanoic and decanoic acids in the control of seizuresQ42009618
Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function.Q42496287
A fatty acid in the MCT ketogenic diet for epilepsy treatment blocks AMPA receptorsQ43607902
Blood Brain Barrier Permeability to LactateQ44030087
A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsyQ44147677
Fatty acid transport through the blood-brain barrierQ48117653
Localization and effect of ectopic expression of CPT1c in CNS feeding centersQ48141559
Antioxidative effect of rice bran oil and medium chain fatty acid rich rice bran oil in arsenite induced oxidative stress in ratsQ48184445
Acute anticonvulsant effects of capric acid in seizure tests in mice.Q48438676
Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice.Q48735249
Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems.Q48931910
Mitochondrial carnitine-acylcarnitine translocase deficiency presenting as sudden neonatal death.Q51573954
Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus.Q51608606
P433issue8
P921main subjecttriglycerideQ186319
P304page(s)1423-1429
P577publication date2017-07-06
P1433published inEpilepsiaQ5382969
P1476titleNeuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet
P478volume58

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cites work (P2860)
Q64965238All You Need Is Fats-for Seizure Control: Using Amoeba to Advance Epilepsy Research.
Q98464774Decanoic Acid and Not Octanoic Acid Stimulates Fatty Acid Synthesis in U87MG Glioblastoma Cells: A Metabolomics Study
Q64926916Differential Metabolism of Medium-Chain Fatty Acids in Differentiated Human-Induced Pluripotent Stem Cell-Derived Astrocytes.
Q58691241Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line
Q47771228Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders.
Q48262986MiR-152 Regulates Apoptosis and Triglyceride Production in MECs via Targeting ACAA2 and HSD17B12 Genes.
Q90543464Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS
Q64110385Randomised trial of add‐on triheptanoin vs. medium chain triglycerides in adults with refractory epilepsy

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