Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia

scientific article published on 10 February 2017

Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1083751383
P356DOI10.1186/S12974-017-0811-Z
P932PMC publication ID5303221
P698PubMed publication ID28187742

P2093author name stringRachel Levy
Nurit Hadad
Yafa Fetfet Malada-Edelstein
P2860cites workFlipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD).Q42585205
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Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation.Q48468478
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Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat.Q49105101
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CD40 is functionally expressed on human thymic epithelial cellsQ67898173
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Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophagesQ73819264
CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammationQ82310803
From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosisQ83940098
The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signalingQ84787241
The role of superoxide radical in TNF-alpha induced NF-kappaB activationQ23923160
LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microgliaQ24685951
CD40/CD40L dyad in the inflammatory and immune responses in the central nervous systemQ28610458
Upregulation of CD40-CD40 ligand (CD154) in patients with acute cerebral ischemia.Q33187134
Oxidative stress as a regulator of gene expression in the vasculatureQ33751805
Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.Q33826817
Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosisQ33835268
CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40Q34721501
LPS/TLR4 signal transduction pathwayQ34756268
CD40-CD40L interactions induce chemokine expression by human microglia: implications for human immunodeficiency virus encephalitis and multiple sclerosisQ35747327
Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathwayQ36234872
Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesisQ36300832
Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytesQ36325071
The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system.Q36369234
Redox-sensitive kinases of the nuclear factor-kappaB signaling pathwayQ36598867
Reduction of cytosolic phospholipase A2α upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosisQ36955096
CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-kappaB (NFkappaB) and activator protein-1 (AP-1)Q37091615
Functional CD40 ligand is expressed by T cells in rheumatoid arthritisQ37374541
Molecular mechanism and function of CD40/CD40L engagement in the immune system.Q37474929
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosisQ37696199
Impact of the CD40-CD40L dyad in Alzheimer's diseaseQ37703298
The CD40/CD40L system: a new therapeutic target for diseaseQ38124660
The role of cytosolic phospholipase A2 α in amyloid precursor protein induction by amyloid beta1-42 : implication for neurodegenerationQ38302052
Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domainQ39944302
Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophagesQ40370493
Role of CD40-CD40-ligand interaction in Ig-isotype switchingQ40386054
Tumor necrosis factor receptor-mediated signaling pathwaysQ40669397
Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophagesQ40752461
Immune regulation by CD40 and its ligand GP39.Q41039754
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.Q41067671
Interleukin-4 inhibits the gene expression and biosyntheis of cytosolic phospholipase A2 in lipopolysaccharide stimulated U937 macrophage cell line and freshly prepared adherent rheumatoid synovial cellsQ41135163
Functional CD40 antigen on B cells, dendritic cells and fibroblasts.Q41388192
Activation of human dendritic cells through CD40 cross-linking.Q41440958
Functions of CD40 on B cells, dendritic cells and other cellsQ41514641
An immortalized cell line expresses properties of activated microglial cellsQ41630691
The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cellsQ41691008
Expression of functional CD40 by vascular endothelial cellsQ41981036
Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan. Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidaseQ42231755
Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathwaysQ42470898
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmicrogliaQ1622829
P304page(s)33
P577publication date2017-02-10
P1433published inJournal of NeuroinflammationQ15716679
P1476titleRegulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia
P478volume14

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cites work (P2860)
Q92710719Beneficial role of bioactive lipids in the pathobiology, prevention, and management of HBV, HCV and alcoholic hepatitis, NAFLD, and liver cirrhosis: A review
Q40105742Combination of EPA with Carotenoids and Polyphenol Synergistically Attenuated the Transformation of Microglia to M1 Phenotype Via Inhibition of NF-κB.
Q92578273Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2
Q91638291Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System
Q50084969[Relationship between cytoplasmic phospholipase A2 and nuclear factor κB in one lung ventilation-induced lung injury in rabbits].

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