Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival

scientific article published on 16 January 2017

Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/2326-6066.CIR-16-0210
P932PMC publication ID5421625
P698PubMed publication ID28093446

P50authorDavid M KoelleQ40734874
Ioannis GavvovidisQ54836861
P2093author name stringDavid Crispin
Paul Nghiem
Martin McIntosh
Matthew P Fitzgibbon
Thomas Blankenstein
Lichun Dong
Lichen Jing
Natalie J Miller
Gerald Willimsky
Kristina Lachance
Michi Shinohara
Candice D Church
P2860cites workGene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigenQ24623215
Clonal integration of a polyomavirus in human Merkel cell carcinomaQ24657675
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.Q27853379
Merkel cell carcinoma: prognosis and treatment of patients from a single institutionQ28242597
Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding PropertiesQ57372665
Limit-dilution assay and clonal expansion of all T cells capable of proliferationQ72116017
Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activityQ74292770
PD-1 blockade induces responses by inhibiting adaptive immune resistanceQ29620856
TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transferQ30576352
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigensQ33966574
PANDAseq: paired-end assembler for illumina sequencesQ34158516
Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging systemQ34208807
CD8+ lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival: a population-based study.Q34240920
Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma PatientsQ34267871
Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.Q34866209
Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors.Q34985137
Linking T-cell receptor sequence to functional phenotype at the single-cell levelQ35111823
Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood.Q35510910
Determinants of public T cell responsesQ35958856
Immune epitope database analysis resourceQ36088427
Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6Q36154471
Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirusQ36498051
Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.Q36585604
Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stageQ36605019
Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions.Q36633084
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapyQ36653748
T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infectionQ36672239
Merkel cell carcinoma: 30-year experience from a single institutionQ38064764
Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinomaQ38084205
T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donorsQ38871209
Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinomaQ38966773
An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cellsQ39574886
High avidity antigen-specific CTL identified by CD8-independent tetramer stainingQ40618338
High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL.Q40830770
High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.Q40978441
Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-IQ41866420
Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer.Q42214828
Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markersQ42278531
Direct link between mhc polymorphism, T cell avidity, and diversity in immune defenseQ43604283
Prognostic factors in Merkel cell carcinoma: analysis of 240 casesQ44269215
Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogueQ44788642
MiXCR: software for comprehensive adaptive immunity profiling.Q48193977
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectMerkel cell polyomavirusQ1921796
P304page(s)137-147
P577publication date2017-01-16
P1433published inCancer Immunology ResearchQ26841983
P1476titleTumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival
P478volume5