Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF-κB.

scientific article published on 30 September 2016

Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF-κB. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3892/OL.2016.5217
P932PMC publication ID5104245
P698PubMed publication ID27895780

P50authorLucina Bobadilla-MoralesQ54435083
Lucina Bobadilla-MoralesQ54435088
Jorge Román Corona-RiveraQ55711739
P2093author name stringAlfredo Corona-Rivera
Juan S Armendáriz-Borunda
Betsy Annel González-Quezada
Helia Judith Pimentel-Gutiérrez
Rocío Silva-Cruz
César Cenobio Barba-Barba
Citlalli Ortega-De-La-Torre
Fernando Antonio Sánchez-Zubieta
P2860cites workCurcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosisQ44189582
Cytoprotective and Cytotoxic Effects of Curcumin: Dual Action on H2O2-Induced Oxidative Cell Damage in NG108-15 CellsQ44433662
Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.Q52973572
[Expression of nuclear transcription factor kappaB in childhood acute lymphoblastic leukemia and its significance]Q80817829
NF-kappaB in carcinoma therapy and preventionQ81768343
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xlQ28213620
Nuclear factor-kappaB activation: from bench to bedsideQ28262629
Apoptosis: a review of programmed cell deathQ28305845
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program.Q31012437
Dose escalation of a curcuminoid formulationQ33236898
Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cellsQ33906004
I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphomaQ34133753
Curcumin-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage.Q34466500
Targeting transcription factors for cancer gene therapy.Q34494104
Upregulation of p53 expression in patients with colorectal cancer by administration of curcuminQ34626926
Curcumin and cancer: an "old-age" disease with an "age-old" solutionQ34776812
Phase II trial of curcumin in patients with advanced pancreatic cancerQ34796370
Multiple molecular targets in cancer chemoprevention by curcuminQ36616301
New therapeutic strategies for the treatment of acute lymphoblastic leukaemiaQ36724661
Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissuesQ36869637
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcuminQ37089549
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteinsQ37163664
Inflammation and cancer: how friendly is the relationship for cancer patients?Q37316105
Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?Q37378063
NF-kappaB as a critical link between inflammation and cancerQ37412699
8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesisQ37468730
Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy.Q37676478
Curcumin, a component of turmeric: from farm to pharmacyQ38075863
Curcumin potentiates antitumor activity of L-asparaginase via inhibition of the AKT signaling pathway in acute lymphoblastic leukemiaQ39425215
Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells.Q40267420
Dosage effects of curcumin on cell death types in a human osteoblast cell lineQ40290259
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphomaQ40397270
Activation of nuclear factor-kappa B is linked to resistance to neoadjuvant chemotherapy in breast cancer patients.Q42496035
Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cellsQ43787464
Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer.Q44049912
P433issue5
P921main subjectlymphoblastic leukemiaQ18553852
curcuminQ312266
NF-κBQ411114
P304page(s)4117-4124
P577publication date2016-09-30
P1433published inOncology LettersQ20640514
P1476titleCurcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF-κB.
P478volume12

Reverse relations

cites work (P2860)
Q49906268Antimalarial drug mefloquine inhibits nuclear factor kappa B signaling and induces apoptosis in colorectal cancer cells
Q91644083Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia
Q92669135In vitro effect of curcumin in combination with chemotherapy drugs in Ph+ acute lymphoblastic leukemia cells
Q47729970Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application.

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