Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures

scientific article published on 04 October 2016

Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures is …
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scholarly articleQ13442814

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P356DOI10.1016/J.EJMECH.2016.10.002
P698PubMed publication ID27750154

P50authorDominique ScholsQ47698773
Robert SnoeckQ47921736
Graciela AndreiQ47921752
Dorota G PiotrowskaQ91168646
P2093author name stringMagdalena Łysakowska
P2860cites workCurrent and potential therapies for the treatment of herpesvirus infectionsQ34288112
Acyclovir-resistant varicella zoster virus infection after chronic oral acyclovir therapy in patients with the acquired immunodeficiency syndrome (AIDS).Q34642523
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Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activityQ34796481
FV-100: the most potent and selective anti-varicella zoster virus agent reported to dateQ37669621
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Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: the advances continue.Q38280668
Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.Q38842365
New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybridsQ38876027
Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analoguesQ38987455
The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linkerQ39064037
N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.Q39203403
Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).Q40080324
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine coreQ40109148
Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivativesQ40334043
Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesvirusesQ40745363
Design, synthesis, antiviral, and cytostatic evaluation of novel isoxazolidine analogs of homonucleotidesQ42236476
ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2.Q43037299
Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templatesQ43110555
Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitisQ45401104
Emergence of acyclovir-resistant varicella zoster virus in an AIDS patient on prolonged acyclovir therapy.Q45851078
Varicella and herpes zoster. Changing concepts of the natural history, control, and importance of a not-so-benign virusQ70171440
2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerasesQ80158732
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubilityQ84077427
P407language of work or nameEnglishQ1860
P304page(s)84-100
P577publication date2016-10-04
P1433published inEuropean Journal of Medicinal ChemistryQ3008624
P1476titleSynthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures
P478volume126

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cites work (P2860)
Q38695987Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides
Q92311079Discovery of 6-Arylurea-2-arylbenzoxazole and 6-Arylurea-2-arylbenzimidazole Derivatives as Angiogenesis Inhibitors: Design, Synthesis and in vitro Biological Evaluation