N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

scientific article published on 3 January 2013

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMC.2012.12.027
P698PubMed publication ID23357038
P5875ResearchGate publication ID235378534

P50authorVladimir Valuev-EllistonQ85980387
Jan BalzariniQ93167025
Anastasia L KhandazhinskayaQ97897994
Maria P ParamonovaQ114421051
Sergey KochetkovQ39382787
Alexander IvanovQ42321534
Robert SnoeckQ47921736
Graciela AndreiQ47921752
Christophe PannecouqueQ50551511
Denis A. BabkovQ52579558
Katherine L. Seley-RadtkeQ57405174
P2093author name stringMikhail S Novikov
Sergey A Gavryushov
P2860cites workAssessment of Docking Poses:  Interactions-Based Accuracy Classification (IBAC) versus Crystal Structure DeviationsQ62582760
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitorsQ27651379
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant virusesQ27652334
Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptaseQ27652894
Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase InhibitorQ28323582
SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2Q28346130
U-90152, a potent inhibitor of human immunodeficiency virus type 1 replicationQ28368034
L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptaseQ28378789
The HIV-1 reverse transcription (RT) process as target for RT inhibitorsQ28646665
Improving non-nucleoside reverse transcriptase inhibitors for first-line treatment of HIV infection: the development pipeline and recent clinical dataQ31161564
Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strainsQ34601887
Computationally-guided optimization of a docking hit to yield catechol diethers as potent anti-HIV agentsQ35673318
New non-nucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infectionsQ35879807
1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agentsQ39477060
Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant virusesQ39780409
Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical propertiesQ39844929
The structure-activity relationships of 2,4(1H,3H)-pyrimidinedione derivatives as potent HIV type 1 and type 2 inhibitorsQ40042904
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitorQ40328156
TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1.Q40425001
New methods for the synthesis of N-benzoylated uridine and thymidine derivatives; a convenient method for N-debenzoylationQ43884027
Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.Q54235667
Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.Q54718103
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1150-1158
P577publication date2013-01-03
P1433published inBioorganic & Medicinal ChemistryQ2904200
P1476titleN1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase
P478volume21

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cites work (P2860)
Q409579752-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
Q361751685-Arylaminouracil Derivatives as Potential Dual-Action Agents
Q46502793Chemometrics approach for the prediction of structure-activity relationship for membrane transporter bilitranslocase
Q38695987Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides
Q41040182Double Variational Binding--(SMILES) Conformational Analysis by Docking Mechanisms for Anti-HIV Pyrimidine Ligands.
Q60949593Novel 5'-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents
Q59351314Recent advances in the design and development of NNRTI scaffolds
Q42707689Synthesis of novel 2-(substituted amino)alkylthiopyrimidin-4(3H)-ones as potential antimicrobial agents.
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Q38740588Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures

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