The HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells.

scientific article published on 3 August 2016

The HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2016.07.025
P8608Fatcat IDrelease_x5i22t2ah5db3lj4z5fhn65wau
P932PMC publication ID5026607
P698PubMed publication ID27497185

P50authorWilliam E MillerQ55187035
P2093author name stringShu-En Wu
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Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptorQ41428523
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The expression of the cytomegalovirus chemokine receptor homolog US28 sequesters biologically active CC chemokines and alters IL-8 productionQ74675227
Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28Q77779509
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US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cellsQ34500430
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'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47.Q35021793
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Human cytomegalovirus (HCMV) infection of endothelial cells promotes naive monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of HCMVQ35140023
Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12.Q35704720
Regulation of CX3CL1/fractalkine expression in endothelial cellsQ35739373
Pathogenesis of human cytomegalovirus infection and cellular targetsQ35789320
Gα13 mediates human cytomegalovirus-encoded chemokine receptor US28-induced cell death in melanomaQ35832550
The human cytomegalovirus lytic cycle is induced by 1,25-dihydroxyvitamin D3 in peripheral blood monocytes and in the THP-1 monocytic cell lineQ35893959
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P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
endotheliumQ111140
P304page(s)233-243
P577publication date2016-08-04
P1433published inVirologyQ7934867
P1476titleThe HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells
P478volume497

Reverse relations

cites work (P2860)
Q40413162Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28.
Q92482120Cell Line Models for Human Cytomegalovirus Latency Faithfully Mimic Viral Entry by Macropinocytosis and Endocytosis
Q47147600Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection
Q58734475Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation
Q56701979The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response
Q58734495US28: HCMV's Swiss Army Knife

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