Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib

scientific article published on 19 July 2016

Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YGYNO.2016.07.088
P932PMC publication ID5031537
P698PubMed publication ID27444036

P2093author name stringAndrew J Wilson
Dineo Khabele
Marta A Crispens
Jeanette Saskowski
Toby Barrack
Alexandra Steck
Kofi Sarfo-Kantanka
P2860cites workPoly (ADP-ribose) polymerase inhibitors: recent advances and future development.Q35895214
Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.Q35897417
BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study GroupQ36145443
Romidepsin (FK228) combined with cisplatin stimulates DNA damage-induced cell death in ovarian cancerQ36521908
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage controlQ36639688
Evaluating cell lines as tumour models by comparison of genomic profilesQ37025950
Profile of panobinostat and its potential for treatment in solid tumors: an updateQ37324186
Synthetic lethality between CCNE1 amplification and loss of BRCA1.Q37353157
Reversing Platinum Resistance in High-Grade Serous Ovarian Carcinoma: Targeting BRCA and the Homologous Recombination SystemQ37611723
Panobinostat for the treatment of relapsed or relapsed/refractory multiple myeloma: pharmacology and clinical outcomesQ38616807
Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancerQ39100297
Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free intervalQ39712677
Functional characterization of a novel BRCA1-null ovarian cancer cell line in response to ionizing radiationQ40177923
Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cellsQ42081115
The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects.Q42699806
Cell line designation change: multidrug-resistant cell line in the NCI anticancer screenQ42818142
Whole-genome characterization of chemoresistant ovarian cancer.Q50272478
Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutationQ56240758
Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian CancerQ56807699
XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsQ24597771
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriersQ27851474
Integrated genomic analyses of ovarian carcinomaQ27860518
Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphomaQ28534761
Cancer statistics, 2016Q29547383
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
Hallmarks of 'BRCAness' in sporadic cancersQ29618825
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trialQ29619615
Residual gammaH2AX foci as an indication of lethal DNA lesionsQ33522060
DNA fingerprinting of the NCI-60 cell line panelQ33608214
The therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancerQ33659166
Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancerQ33754744
Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome StabilityQ34417264
Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancerQ35141937
Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS.Q35176113
Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocationsQ35212139
Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenograftsQ35448716
Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy.Q35542762
The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cellsQ35556954
Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancerQ35631181
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
P304page(s)143-151
P577publication date2016-07-19
P1433published inGynecologic OncologyQ5625182
P1476titlePanobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib
P478volume143

Reverse relations

cites work (P2860)
Q89649803CCNE1 and BRD4 co-amplification in high-grade serous ovarian cancer is associated with poor clinical outcomes
Q97692537Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
Q49340516Fanconi Anemia Signaling and Cancer
Q91995960Interferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer
Q52642120The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.
Q97524894Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer

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