Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

scientific article

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLONC.2014.01.008
P932PMC publication ID4400120
P698PubMed publication ID24560445
P5875ResearchGate publication ID259892941

P50authorStephen FoxQ30506440
Scott H KaufmannQ40592168
Matthew WakefieldQ42853296
David BowtellQ47451431
Kathryn AlsopQ56840332
Karla J HuttQ61096480
P2093author name stringDariush Etemadmoghadam
Elizabeth M Swisher
Laura Galletta
Gillian Mitchell
Clare L Scott
Australian Ovarian Cancer Study
Jan Pyman
Jeffrey B Kerr
Orla McNally
Sumitra Ananda
Lynne Hartley
Valerie Heong
Michele Cook
Emma Boehm
Lauren McShane
Marisol Harrell
Monique D Topp
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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trialQ29619615
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescenceQ29620428
Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer IntergroupQ30436714
Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancerQ83145997
Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancerQ33754744
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancersQ33886925
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumorsQ33896961
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutationQ33930051
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.Q33944203
Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovaryQ34103978
Phenotypic heterogeneity and instability of human ovarian tumor-initiating cellsQ34836634
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A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genesQ36492194
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancersQ36958682
Evaluating cell lines as tumour models by comparison of genomic profilesQ37025950
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimeticsQ37431491
Update of randomized trials in first-line treatmentQ37969715
Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies.Q39542474
Development of a syngeneic mouse model for events related to ovarian cancerQ40888613
Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapyQ46244368
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencingQ47163678
Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian CancerQ56807699
Secondary mutations inBRCA2associated with clinical resistance to a PARP inhibitorQ58053593
Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenograftsQ64387019
Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential modelsQ81120942
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectplatinumQ880
ovarian cancerQ172341
patientQ181600
xenograftQ64148587
P304page(s)656-668
P577publication date2014-01-24
P1433published inMolecular OncologyQ2190736
P1476titleMolecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts
P478volume8

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