Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models

scientific article published on 19 December 2016

Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-16-2273
P932PMC publication ID5474193
P698PubMed publication ID27993965

P50authorMeenhard HerlynQ16732421
Clemens KreplerQ61529607
P2093author name stringMark Morgan
Eric Brown
Fiona Simpkins
Hyoung Kim
Rugang Zhang
Erin George
Ryan Ragland
Stavros Rafial
P2860cites workATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Q24550952
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenanceQ24672646
Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 studyQ27853070
Integrated genomic analyses of ovarian carcinomaQ27860518
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Q28131668
Caspases: opening the boxes and interpreting the arrowsQ28216089
Apoptosis and cancer: mutations within caspase genesQ28247775
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeuticsQ28266884
PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients withQ90727675
ColonyArea: an ImageJ plugin to automatically quantify colony formation in clonogenic assaysQ28364520
ATR disruption leads to chromosomal fragmentation and early embryonic lethalityQ28591433
Chk1 and Chk2 kinases in checkpoint control and cancerQ29617706
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trialQ29619615
Causes and consequences of replication stressQ34394094
Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial.Q34422265
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent mannerQ34676703
ATR prohibits replication catastrophe by preventing global exhaustion of RPA.Q35051406
Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuitQ35131775
Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenograftsQ35448716
Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATRQ35640593
Chk’ing p53-deficient breast cancersQ35858171
Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cellsQ36054977
CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiationQ36280773
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.Q36908567
Prognostic factors for stage III epithelial ovarian cancer: a Gynecologic Oncology Group StudyQ36912591
Dasatinib (BMS-35482) potentiates the activity of gemcitabine and docetaxel in uterine leiomyosarcoma cell linesQ36929175
ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.Q36941455
ATR phosphorylates SMARCAL1 to prevent replication fork collapseQ37064611
DNA repair deficiency as a therapeutic target in cancerQ37110904
Death through a tragedy: mitotic catastropheQ37135368
CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumorsQ37168650
RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cellsQ37271812
A patient-derived-xenograft platform to study BRCA-deficient ovarian cancersQ37558633
Tumorgrafts as in vivo surrogates for women with ovarian cancer.Q37626455
Mechanisms of resistance to therapies targeting BRCA-mutant cancersQ38160737
Protein ADP-ribosylation and the cellular response to DNA strand breaksQ38206322
Molecular Pathways: Targeting ATR in Cancer TherapyQ38585436
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and ExpandedQ38787667
Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.Q39559122
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in XenopusQ41846285
New insights into PARP inhibitors' effect on cell cycle and homology-directed DNA damage repairQ44756445
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised studyQ44846367
ATR inhibition preferentially targets homologous recombination-deficient tumor cells.Q54326103
Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutationQ56240758
The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatinQ78835035
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
P304page(s)3097-3108
P577publication date2016-12-19
P1433published inClinical Cancer ResearchQ332253
P1476titleTargeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models
P478volume23

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cites work (P2860)
Q92890485A decade of clinical development of PARP inhibitors in perspective
Q90399238ATM-Deficient Cancers Provide New Opportunities for Precision Oncology
Q47643551ATR Is a Therapeutic Target in Synovial Sarcoma.
Q42315217ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.
Q90239010ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells
Q55306606Advances in therapeutic targeting of the DNA damage response in cancer.
Q61136915Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
Q92476256Applications of patient-derived tumor xenograft models and tumor organoids
Q47164964BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer
Q90562787Bayesian inference of hub nodes across multiple networks
Q90622524Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
Q90827979Choosing wisely: Selecting PARP inhibitor combinations to promote anti-tumor immune responses beyond BRCA mutations
Q57176137Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status
Q52615755Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Q95660697Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells
Q98565962Combining PARP inhibitors with platinum or ruthenium-based complexes for cancer therapy
Q97692537Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
Q63446284Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference
Q96168423DNA damage checkpoint kinases in cancer
Q96432061Differential therapeutic effects of PARP and ATR inhibition combined with radiotherapy in the treatment of subcutaneous versus orthotopic lung tumour models
Q89994199Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer
Q88875414Expression, activation and clinical relevance of CHK1 and CHK2 in metastatic high-grade serous carcinoma
Q90372233Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition
Q58801181Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management
Q99548779Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach
Q64999993MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer.
Q92612315Mitotic functions of poly(ADP-ribose) polymerases
Q90308673Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan
Q91564632Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
Q89880356Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant BRCA1 Mutant Ovarian Cells
Q89581160PARP and PARG inhibitors in cancer treatment
Q64279560PARP inhibitors in ovarian cancer: Sensitivity prediction and resistance mechanisms
Q92126687Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer
Q90142332Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition-mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2-deficient cancer cells
Q92812787Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer
Q93157621Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells
Q48534871Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases in vitro toxicity of PARP inhibition by preventing Rad51 foci formation in BRCA wild type high-grade serous ovarian cancer
Q97537635Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer
Q57793601State-of-the-art strategies for targeting the DNA damage response in cancer
Q89095370Targeting ATR in cancer
Q90707206Targeting DNA repair in cancer: current state and novel approaches
Q47111141The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1+/- lymphoblastoid cells
Q95267029The dynamic landscape of BRCA1 reversion mutations from indel to SNV in a patient with ovarian cancer treated with PARP-inhibitors and immunotherapy
Q90529610The tubal epigenome - An emerging target for ovarian cancer
Q89727327Therapeutic Application of PARP Inhibitors in Neuro-Oncology
Q41552673Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors.

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