| scholarly article | Q13442814 |
| P2093 | author name string | Jie Zhang | |
| Junjie Chen | |||
| Nora M Navone | |||
| Chao Wang | |||
| Zhen Chen | |||
| Gang Wang | |||
| Xu Feng | |||
| Mengfan Tang | |||
| Mrinal Srivastava | |||
| Peter Shepherd | |||
| Megan E McLaughlin | |||
| Glen Traver Hart | |||
| P2860 | cites work | MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling | Q24304423 |
| RNase H2 roles in genome integrity revealed by unlinking its activities | Q27676027 | ||
| A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes | Q27972929 | ||
| The Causes and Consequences of Topological Stress during DNA Replication | Q28077125 | ||
| Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice | Q28143813 | ||
| Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal | Q28288215 | ||
| Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity | Q28505683 | ||
| ATR disruption leads to chromosomal fragmentation and early embryonic lethality | Q28591433 | ||
| The mutational landscape of lethal castration-resistant prostate cancer | Q29614634 | ||
| Proteomics. Tissue-based map of the human proteome | Q29617248 | ||
| Integrative genomic profiling of human prostate cancer | Q29619905 | ||
| RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases | Q33779326 | ||
| cGAS is essential for cellular senescence | Q33790789 | ||
| A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression | Q33850539 | ||
| Genome instability due to ribonucleotide incorporation into DNA. | Q34142849 | ||
| Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 | Q34221860 | ||
| Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. | Q34274334 | ||
| Causes and consequences of replication stress | Q34394094 | ||
| Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection | Q34548112 | ||
| The Molecular Taxonomy of Primary Prostate Cancer | Q34674332 | ||
| Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instability | Q34920730 | ||
| AGS, SLE, and RNASEH2 mutations: translating insights into therapeutic advances | Q35242554 | ||
| High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. | Q35858015 | ||
| SLFN11 inhibits checkpoint maintenance and homologous recombination repair | Q35866775 | ||
| BAGEL: a computational framework for identifying essential genes from pooled library screens. | Q35991327 | ||
| Bridging the gap between in vitro and in vivo: Dose and schedule predictions for the ATR inhibitor AZD6738 | Q35999359 | ||
| The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy | Q36289912 | ||
| Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control | Q36490482 | ||
| Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation. | Q36525188 | ||
| RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. | Q36745063 | ||
| Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response | Q36866528 | ||
| Synonymous mutations in RNASEH2A create cryptic splice sites impairing RNase H2 enzyme function in Aicardi-Goutières syndrome. | Q37022007 | ||
| Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria | Q37142690 | ||
| A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors | Q37268724 | ||
| Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer | Q37302524 | ||
| ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. | Q37508792 | ||
| The essential kinase ATR: ensuring faithful duplication of a challenging genome. | Q38622938 | ||
| Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens. | Q38706202 | ||
| Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors | Q38729876 | ||
| Targeting the ATR-CHK1 Axis in Cancer Therapy | Q38817102 | ||
| Measuring error rates in genomic perturbation screens: gold standards for human functional genomics | Q38978817 | ||
| ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency | Q39012252 | ||
| The impact of replication stress on replication dynamics and DNA damage in vertebrate cells. | Q39438600 | ||
| Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. | Q39559122 | ||
| Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. | Q42745810 | ||
| Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy | Q46289705 | ||
| Genome-Wide CRISPR/Cas9 Screening for High-Throughput Functional Genomics in Human Cells. | Q47951609 | ||
| The role of RNase H2 in processing ribonucleotides incorporated during DNA replication. | Q50212840 | ||
| ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells | Q50913049 | ||
| Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models | Q52811875 | ||
| Methylation of SLFN11 is a marker of poor prognosis and cisplatin resistance in colorectal cancer | Q52881647 | ||
| Integrative Clinical Genomics of Advanced Prostate Cancer | Q53788627 | ||
| CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions | Q59084697 | ||
| The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer | Q88286449 | ||
| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | CRISPR | Q412563 |
| P304 | page(s) | 2451-2463 | |
| P577 | publication date | 2018-12-07 | |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition | |
| P478 | volume | 38 |
| Q90042293 | A consensus set of genetic vulnerabilities to ATR inhibition |
| Q102140719 | Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy |
| Q92540221 | Chemogenetic interactions in human cancer cells |
| Q92992933 | Control of homologous recombination by the HROB-MCM8-MCM9 pathway |
| Q91999877 | Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition |
| Q90428476 | High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase |
| Q92787848 | Identifying chemogenetic interactions from CRISPR screens with drugZ |
| Q95940288 | Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions |
| Q96302601 | MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage |
| Q91944953 | Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair |
| Q89759382 | Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity |
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