Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

scientific article published on July 2016

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NEUONC/NOW106
P932PMC publication ID5063519
P698PubMed publication ID27370397

P50authorRishi R LullaQ95991384
Sabine MüllerQ89245124
P2093author name stringC David James
Jann N Sarkaria
Stewart Goldman
Craig Horbinski
Michael D Prados
Rintaro Hashizume
Daphne A Haas-Kogan
Andrew P Mazar
Todd Waldman
Shi-Yuan Cheng
Alexander H Stegh
Ali Zhang
Amanda M Saratsis
P2860cites workPharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenograftsQ27851556
Targeting CDK4 and CDK6: From Discovery to TherapyQ28082912
Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumorsQ28294240
PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem gliomaQ28533981
A human brainstem glioma xenograft model enabled for bioluminescence imagingQ33599189
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.Q33968055
Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testingQ34132814
Clonogenic assay of cells in vitro.Q34615431
Advancing bioluminescence imaging technology for the evaluation of anticancer agents in the MDA-MB-435-HAL-Luc mammary fat pad and subrenal capsule tumor modelsQ34913322
p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumorsQ35133362
Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expressionQ35545894
p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cellsQ36048184
Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cellsQ36377759
The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicityQ36416243
Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cellsQ36544065
Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.Q37412251
Targeting cell cycle and hormone receptor pathways in cancer.Q37502364
FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor-Positive, HER2-Negative Metastatic Breast CancerQ38577772
Coadministration of Trametinib and Palbociclib Radiosensitizes KRAS-Mutant Non-Small Cell Lung Cancers In Vitro and In VivoQ38806736
Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteriaQ40044872
Response of intracerebral human glioblastoma xenografts to multifraction radiation exposuresQ40244447
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.Q40440656
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.Q40492303
P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cellsQ40618783
Establishing intracranial brain tumor xenografts with subsequent analysis of tumor growth and response to therapy using bioluminescence imagingQ41969010
Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiformeQ42124124
Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panelQ43491437
Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysisQ43606948
Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB.Q44083876
Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumorsQ44214973
A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.Q53607571
Early clinical outcomes using proton radiation for children with central nervous system atypical teratoid rhabdoid tumorsQ86406352
P4510describes a project that usesImageJQ1659584
P433issue11
P921main subjectglioblastomaQ282142
atypical teratoid rhabdoid tumorQ631904
DNA damageQ5205747
rhabdoid tumorQ6743515
xenograftQ64148587
P304page(s)1519-1528
P577publication date2016-07-01
P1433published inNeuro-OncologyQ15724471
P1476titleInhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth
P478volume18

Reverse relations

cites work (P2860)
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Q92962778Modulating lncRNA SNHG15/CDK6/miR-627 circuit by palbociclib, overcomes temozolomide resistance and reduces M2-polarization of glioma associated microglia in glioblastoma multiforme
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Q37632170Progress with palbociclib in breast cancer: latest evidence and clinical considerations
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Q64053923Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease
Q39183079The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies