scholarly article | Q13442814 |
P356 | DOI | 10.1172/JCI41402 |
P8608 | Fatcat ID | release_bgtxwqh5kjfs3nfjspc2vul2bu |
P932 | PMC publication ID | 2898594 |
P698 | PubMed publication ID | 20577054 |
P5875 | ResearchGate publication ID | 44799096 |
P50 | author | Norman Sharpless | Q21260355 |
Kwok Kin Wong | Q42687956 | ||
Matthew R. Ramsey | Q55130884 | ||
P2093 | author name string | Qi Jiang | |
Yong Wang | |||
Lishan Su | |||
Jian Jin | |||
Daohong Zhou | |||
Chad D Torrice | |||
Kimberly B Monahan | |||
Jessica F Bell | |||
Søren M Johnson | |||
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A Restriction Point for Control of Normal Animal Cell Proliferation | Q24620882 | ||
E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases | Q24646412 | ||
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair | Q28118984 | ||
p21 is a universal inhibitor of cyclin kinases | Q28257305 | ||
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6 | Q28277471 | ||
Cyclin-dependent kinase pathways as targets for cancer treatment | Q28306405 | ||
Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275 | Q28342649 | ||
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X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells | Q72813361 | ||
Protection of normal proliferating cells against chemotherapy by staurosporine-mediated, selective, and reversible G(1) arrest | Q73308223 | ||
Hematopoietic stem cell quiescence maintained by p21cip1/waf1 | Q73532192 | ||
Protective effect of a colchicine derivative in mice exposed to x-radiation | Q74798022 | ||
Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival | Q78618574 | ||
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X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells | Q79630305 | ||
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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells | Q29615006 | ||
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The restriction point of the cell cycle | Q34528876 | ||
Clonogenic assay of cells in vitro. | Q34615431 | ||
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models | Q34769152 | ||
Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. | Q34792542 | ||
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo | Q35195311 | ||
DNA damage checkpoint control in cells exposed to ionizing radiation | Q35208818 | ||
Living with or without cyclins and cyclin-dependent kinases | Q35951291 | ||
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates | Q36403978 | ||
Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice | Q36827513 | ||
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. | Q37079677 | ||
History and development of radiation-protective agents | Q37532178 | ||
DNA interstrand cross-links induced by ionizing radiation: an unsung lesion | Q37676505 | ||
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Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy | Q39785729 | ||
Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage | Q39812237 | ||
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma | Q40169723 | ||
Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity | Q40215990 | ||
Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers | Q40243253 | ||
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. | Q40440656 | ||
Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. | Q40459672 | ||
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. | Q40492303 | ||
Induction of DNA synthesis and apoptosis are separable functions of E2F-1. | Q41099375 | ||
Relationship between chromatin structure, DNA damage and repair following X-irradiation of human lymphocytes | Q43125004 | ||
Synthesis, Structure−Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors | Q44441519 | ||
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Treatment of growing teratoma syndrome | Q46151057 | ||
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Mouse development and cell proliferation in the absence of D-cyclins. | Q52088064 | ||
Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. | Q53333234 | ||
Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. | Q53377245 | ||
X-Ray Damage and Recovery in Mammalian Cells in Culture | Q59085189 | ||
Repair of Sub-lethal and Potentially Lethal Radiation Damage in Plateau Phase Cultures of Human Cells | Q59086536 | ||
The comet assay: a method to measure DNA damage in individual cells | Q64388028 | ||
The formation of radiation-induced DNA breaks: the ratio of double-strand breaks to single-strand breaks | Q64390519 | ||
Anthracyclines, mitoxantrone, radiotherapy, and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer. | Q64972919 | ||
In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice | Q67653319 | ||
P4510 | describes a project that uses | ImageJ | Q1659584 |
P433 | issue | 7 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | toxicity | Q274160 |
P304 | page(s) | 2528-2536 | |
P577 | publication date | 2010-06-23 | |
P1433 | published in | Journal of Clinical Investigation | Q3186904 |
P1476 | title | Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition | |
P478 | volume | 120 |
Q34987777 | ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage |
Q36722804 | Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice |
Q34053479 | Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity |
Q37372449 | An inducible long noncoding RNA amplifies DNA damage signaling. |
Q52820544 | An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo. |
Q35869745 | Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury |
Q33896849 | Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death |
Q64915932 | Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice. |
Q48278280 | Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy. |
Q39185185 | CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage |
Q36130084 | CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy |
Q37575488 | CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. |
Q35635267 | Catalase inhibits ionizing radiation-induced apoptosis in hematopoietic stem and progenitor cells |
Q92592825 | Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy |
Q37693690 | Cell cycle proteins as promising targets in cancer therapy |
Q38728850 | Characterization of Neutropenia in Advanced Cancer Patients Following Palbociclib Treatment Using a Population Pharmacokinetic-Pharmacodynamic Modeling and Simulation Approach. |
Q91345318 | Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancer |
Q26782637 | Chromatin perturbations during the DNA damage response in higher eukaryotes |
Q28242623 | Cyclin D as a therapeutic target in cancer |
Q37798827 | Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor–chemotherapy combinations as an anticancer strategy for solid tumors |
Q51919465 | Dentofacial parameters explaining variability in retroclination of the maxillary central incisors. |
Q28834064 | Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation |
Q36394640 | Does CDKN2A loss predict palbociclib benefit? |
Q38869603 | Emerging targets for radioprotection and radiosensitization in radiotherapy |
Q39836171 | Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr-/-, Cdkn2a-Deficient Mice |
Q90246026 | Epithelial Cell Cycle Behaviour in the Injured Kidney |
Q34541922 | Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.). |
Q35221682 | Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents |
Q21183971 | Genetics and genomics of radiotherapy toxicity: towards prediction |
Q38866877 | HR+, HER2- Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of action, Clinical Activity, and Safety Profiles. |
Q39675064 | HSC senescence upon irradiation |
Q28731776 | HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates |
Q26865273 | Hematopoietic stem cell niche maintenance during homeostasis and regeneration |
Q46581912 | Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors |
Q30371457 | Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay |
Q58795413 | Immune mechanisms in the different phases of acute tubular necrosis |
Q37395807 | Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice |
Q38760366 | Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth |
Q38200606 | Intestinal stem cell injury and protection during cancer therapy |
Q35082713 | Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice |
Q27022997 | Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development |
Q35781547 | MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. |
Q57106504 | Management of adverse events during cyclin-dependent kinase 4/6 (CDK4/6) inhibitor-based treatment in breast cancer |
Q35549264 | Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions |
Q28548371 | Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility |
Q35842970 | Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy |
Q90024802 | Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial |
Q37524270 | NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation. |
Q37160539 | New paradigms and future challenges in radiation oncology: an update of biological targets and technology |
Q35958082 | Palbociclib for the Treatment of Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer |
Q39638408 | Palbociclib in Combination With Fulvestrant in Women With Hormone Receptor-Positive/HER2-Negative Advanced Metastatic Breast Cancer: Detailed Safety Analysis From a Multicenter, Randomized, Placebo-Controlled, Phase III Study (PALOMA-3). |
Q38577715 | Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer |
Q34027724 | Palbociclib: an evidence-based review of its potential in the treatment of breast cancer |
Q30409339 | Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death |
Q24617126 | Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity |
Q28588864 | Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells |
Q35140111 | Pleiotrophin mediates hematopoietic regeneration via activation of RAS. |
Q38832541 | Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors |
Q26770944 | Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome |
Q38544737 | RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy |
Q38196712 | Radioprotection of normal tissue cells |
Q37767574 | Radioprotection: smart games with death |
Q38710560 | Radioprotective Agents: Strategies and Translational Advances. |
Q37801346 | Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo. |
Q35586823 | Runx1 loss minimally impacts long-term hematopoietic stem cells |
Q64064501 | Safety and efficacy profile of cyclin-dependent kinases 4/6 inhibitor palbociclib in cancer therapy: A meta-analysis of clinical trials |
Q38365768 | Searching for targets for the systemic therapy of mesothelioma. |
Q38218129 | Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer. |
Q37006942 | Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice |
Q47662195 | Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury. |
Q28082912 | Targeting CDK4 and CDK6: From Discovery to Therapy |
Q26865765 | Targeting cancer with kinase inhibitors |
Q49547342 | Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer |
Q33816106 | Targeting the cyclin D-cyclin-dependent kinase (CDK) 4/6-retinoblastoma pathway with selective CDK 4/6 inhibitors in hormone receptor-positive breast cancer: rationale, current status, and future directions |
Q28069910 | Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers |
Q35056773 | The evolving role of radiation therapy in the management of malignant melanoma |
Q26865888 | The other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axis |
Q34999987 | The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow |
Q33621603 | Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner |
Q35182633 | Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer |
Q48227806 | Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion |
Q37885468 | Transport processes of radiopharmaceuticals and -modulators. |
Q34988091 | Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. |
Q36234051 | Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells |
Q44274584 | mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL. |