PKCα-GSK3β-NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis

scientific article published on 4 March 2016

PKCα-GSK3β-NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1139/BCB-2016-0009
P698PubMed publication ID27219672

P2093author name stringWensi Huang
Qihao Zhang
Xuejuan Gao
Langxia Liu
Miaojuan Chen
Fengmei Xu
Huan-Tian Zhang
Qingzhong Zeng
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NF-κB targeting by way of IKK inhibition sensitizes lung cancer cells to adenovirus delivery of TRAILQ33729242
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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivityQ35591349
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Protein kinase C and other diacylglycerol effectors in cancerQ36769838
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Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor familyQ38098380
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The molecular mechanisms of TRAIL resistance in cancer cells: help in designing new drugsQ38255598
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Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3.Q38609949
Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cellsQ38950645
Ser9-phosphorylated GSK3β induced by 14-3-3ζ actively antagonizes cell apoptosis in a NF-κB dependent mannerQ38964598
The interruption of PKC-ι signaling and TRAIL combination therapy against glioblastoma cellsQ38981224
Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cellsQ39011040
Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressionsQ39285542
Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cellsQ39927178
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survivalQ39977719
Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53.Q40006116
Inhibition of novel protein kinase C-epsilon augments TRAIL-induced cell death in A549 lung cancer cellsQ40031192
Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cellsQ40123984
Variable expression of protein kinase C epsilon in human melanoma cells regulates sensitivity to TRAIL-induced apoptosisQ40435859
Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.Q40641191
Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein Bad and TRAIL receptorsQ40641394
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.Q40975748
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.Q41747264
Systems Biology Strategy Reveals PKCδ is Key for Sensitizing TRAIL-Resistant Human FibrosarcomaQ42155208
Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stabilityQ44519344
Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signalingQ44550507
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)256-264
P577publication date2016-03-04
P1433published inBiochemistry and Cell BiologyQ4914719
P1476titlePKCα-GSK3β-NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis
P478volume94

Reverse relations

cites work (P2860)
Q54216824TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-linked Polyubiquitination of MAVS.
Q89737191TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma