Is Huntington's disease a tauopathy?

scientific article published on 11 March 2016

Is Huntington's disease a tauopathy? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/BRAIN/AWW021
P698PubMed publication ID26969684
P5875ResearchGate publication ID297890166

P50authorFrancesca CicchettiQ89283451
Emmanuel PlanelQ90328587
Giulia CisbaniQ57167793
Maud GratuzeQ59195478
P2860cites workDual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusionQ24339549
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filamentsQ24599152
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Neuropathological stageing of Alzheimer-related changesQ27860862
Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's diseaseQ28242505
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17Q28274687
Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1Q28306183
Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeatsQ28587110
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceQ29615357
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseQ29617286
Regional and cellular gene expression changes in human Huntington's disease brainQ33233457
Late onset of Huntington's diseaseQ33621109
Huntington's disease: from molecular pathogenesis to clinical treatmentQ33773061
The selective vulnerability of striatopallidal neuronsQ33939097
Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic miceQ34017941
Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairmentQ34198357
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patientsQ34470414
Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.Q34531481
Huntingtin-protein interactions and the pathogenesis of Huntington's diseaseQ35704403
Role of tau protein in both physiological and pathological conditions.Q35715199
The role of tau in the pathological process and clinical expression of Huntington's diseaseQ36066666
CSF biomarkers for mild cognitive impairment and early Alzheimer's diseaseQ36095322
Huntington disease and the huntingtin proteinQ38000622
Tau protein kinases: involvement in Alzheimer's diseaseQ38022361
An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicityQ38038981
Invited review: Neuropathology of tauopathies: principles and practice.Q38286208
Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.Q38957994
Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.Q39014909
The coexistence and differentiation of late onset Huntington's disease and Alzheimer's disease. A case report and review of the literatureQ39484690
Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington diseaseQ40031554
A minimal length between tau exon 10 and 11 is required for correct splicing of exon 10.Q40545077
Formation and propagation of tau oligomeric seedsQ41820128
Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse modelQ41966030
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicityQ42145267
Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoformsQ42468356
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.Q42654706
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau proteinQ42827866
Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.Q43280390
Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.Q45288661
Huntington disease associated with Alzheimer diseaseQ45289814
Association of corticobasal degeneration and Huntington's disease: can Tau aggregates protect Huntingtin toxicity?Q45292769
Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseasesQ45295797
An immunohistochemical investigation of the human neostriatum in Huntington's diseaseQ45296010
Alzheimer-type lesions in Huntington's diseaseQ45297028
Mutant huntingtin is present in neuronal grafts in Huntington disease patientsQ45299114
Dementia of the Alzheimer's type and Huntington's diseaseQ45299681
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.Q45300275
Decreased expression of striatal signaling genes in a mouse model of Huntington's diseaseQ45300376
Mutant huntingtin alters Tau phosphorylation and subcellular distributionQ45301226
Increased levels of total tau protein in the cerebrospinal fluid in Huntington's diseaseQ45303526
Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiologyQ45305215
Biphasic developmental changes in Ca2+/calmodulin-dependent proteins in R6/2 Huntington's disease miceQ45305873
Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6/2 Huntington's disease transgenic miceQ45306790
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylationQ46785508
The role of MAPT sequence variation in mechanisms of disease susceptibilityQ47361624
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s diseaseQ47918430
Anatamopathological spectrum of tauopathiesQ48192397
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoformsQ48254354
Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cellsQ48503134
Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation.Q48521878
An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodiesQ48609551
Modeling the relation between neurofibrillary tangles and intellectual statusQ48710392
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's diseaseQ48820847
Plaques, tangles and dementia. A quantitative studyQ48874775
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.Q50856591
Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia.Q51978000
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this workQ57897029
P433issuePt 4
P407language of work or nameEnglishQ1860
P921main subjectHuntington's diseaseQ190564
P304page(s)1014-1025
P577publication date2016-03-11
P1433published inBrainQ897386
P1476titleIs Huntington's disease a tauopathy?
P478volume139

Reverse relations

cites work (P2860)
Q91784709Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms
Q92966000Dynamical decoration of stabilized-microtubules by Tau-proteins
Q38928751Faulty splicing and cytoskeleton abnormalities in Huntington's disease
Q36002017GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions
Q45303896Gray matter asymmetries in aging and neurodegeneration: A review and meta-analysis
Q64096404Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation
Q41370372Lysine-Directed Post-translational Modifications of Tau Protein in Alzheimer's Disease and Related Tauopathies
Q47280331Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease
Q47104779Overexpression of Tau Rescues Nogo-66-Induced Neurite Outgrowth Inhibition In Vitro
Q45305113Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease
Q39243689Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases
Q90682346Spectrum of tau pathologies in Huntington's disease
Q36291565Tau or neurofilament light-Which is the more suitable biomarker for Huntington's disease?
Q48659268Tau-positive nuclear indentations in P301S tauopathy mice.
Q55027741Tau: A Common Denominator and Therapeutic Target for Neurodegenerative Disorders.
Q57021022The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau)
Q39052041The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
Q42363775Wild type huntingtin toxicity in yeast: Implications for the role of amyloid cross-seeding in polyQ diseases.

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