Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice

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Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...624467R
P356DOI10.1371/JOURNAL.PONE.0024467
P932PMC publication ID3166321
P698PubMed publication ID21912697
P5875ResearchGate publication ID51632800

P2093author name stringMichael Norman
Geetanjali Kharmate
Ujendra Kumar
Padmesh S Rajput
Shi-He Liu
Charles F Brunicardi
Bhagavatula R Sastry
P2860cites workThe role of G-proteins in the dimerisation of human somatostatin receptor types 2 and 5.Q51777226
Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 Co-immunoprecipitation and fluorescence resonance energy transfer analysis.Q51795273
Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient miceQ71483815
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophreniaQ24678573
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Somatostatin and its receptor familyQ28141222
Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleusQ28505053
Decrease in striatal enkephalin mRNA in mouse models of Huntington's diseaseQ28513464
Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brainQ28568771
Developmental and regional expression in the rat brain and functional properties of four NMDA receptorsQ28570615
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brainQ28578792
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascadeQ33703262
Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activityQ33897208
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disordersQ34138025
Molecular genetics: unmasking polyglutamine triggers in neurodegenerative diseaseQ34185510
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acidQ34384772
Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and functionQ34629359
Coupling of the NMDA receptor to neuroprotective and neurodestructive eventsQ35012580
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtinQ35013054
DARPP chocolate: a caffeinated morsel of striatal signalingQ35044987
Neuropeptides involved in the pathophysiology of schizophrenia and major depressionQ35130197
The likelihood of being affected with Huntington disease by a particular age, for a specific CAG sizeQ35238524
On the Role of Somatostatin in Seizure Control: Clues from the HippocampusQ35545445
The potential of activation of somatostatinergic neurotransmission with FK960 in Alzheimer's diseaseQ35609734
Huntingtin-protein interactions and the pathogenesis of Huntington's diseaseQ35704403
Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease miceQ35804816
N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's diseaseQ36692396
The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responsesQ36833070
Expression of NMDA Receptor-1 (NR1) and Huntingtin in Striatal Neurons Which Colocalize Somatostatin, Neuropeptide Y, and NADPH Diaphorase: A Double-Label Histochemical and Immunohistochemical StudyQ36870168
Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptorsQ37120419
Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice.Q37293161
Early synaptic pathophysiology in neurodegeneration: insights from Huntington's diseaseQ37789909
Quinolinic acid-induced increases in calbindin D28k immunoreactivity in rat striatal neurons in vivo and in vitro mimic the pattern seen in Huntington's diseaseQ38298264
C-tail mediated modulation of somatostatin receptor type-4 homo- and heterodimerizations and signalingQ39854714
The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptorsQ40537074
Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor traffickingQ40539553
Calpain activation in Huntington's disease.Q40723358
Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitizationQ40744546
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtinQ40958511
Somatostatin receptor subtypes SSTR2 and SSTR5 couple negatively to an L-type Ca2+ current in the pituitary cell line AtT-20.Q41209456
NMDA receptor losses in putamen from patients with Huntington's diseaseQ41336261
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicityQ41342466
Glutamate receptors in the mammalian central nervous systemQ41742131
Quinolinic acid stimulates somatostatin gene expression in cultured rat cortical neuronsQ42052839
Neurodegeneration of somatostatin-immunoreactive neurons in HIV encephalitisQ42436816
Somatostatin is increased in the basal ganglia in Huntington diseaseQ42449047
Double-gene ablation of SSTR1 and SSTR5 results in hyperinsulinemia and improved glucose tolerance in mice.Q42467071
Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's diseaseQ42503175
NMDA receptor function in mouse models of Huntington diseaseQ43825271
Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's diseaseQ44480462
Differential changes in striatal projection neurons in R6/2 transgenic mice for Huntington's diseaseQ45288683
Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicityQ45291700
Chronic quinolinic acid lesions in rats closely resemble Huntington's diseaseQ45292667
Striatal interneurons in Huntington's disease: selective increase in the density of calretinin-immunoreactive medium-sized neuronsQ45293336
Calbindin D28K as a marker for the degeneration of the striatonigral pathway in Huntington's diseaseQ45294692
Selective sparing of a class of striatal neurons in Huntington's diseaseQ45297134
Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington's disease transgenic miceQ45297311
Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's diseaseQ45299064
Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation.Q45299435
Striatal modulation of cAMP-response-element-binding protein (CREB) after excitotoxic lesions: implications with neuronal vulnerability in Huntington's disease.Q45299845
Changes in expression of N-methyl-D-aspartate receptor subunits occur early in the R6/2 mouse model of Huntington's diseaseQ45301002
Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutationQ45301268
Regional Brain Concentrations of Neuropeptides in Huntington's Chorea and SchizophreniaQ45303808
Somatostatin is increased in the nucleus accumbens in Huntington's diseaseQ45303855
Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.Q45307199
Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic acid and N-methyl-D-asparate-induced neurotoxicityQ46592729
Deficiency of somatostatin (SST) receptor type 5 (SSTR5) is associated with sexually dimorphic changes in the expression of SST and SST receptors in brain and pancreas.Q47274918
Expression of somatostatin and somatostatin receptor subtypes in Apolipoprotein D (ApoD) knockout mouse brain: An immunohistochemical analysisQ47736458
Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamusQ48107703
Expression of N-methyl-D-aspartate receptor subunit NR1 messenger RNA by identified striatal somatostatin cellsQ48169694
Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptorsQ48380135
Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice.Q48700093
Striatal neurons containing both somatostatin- and avian pancreatic polypeptide (APP)-like immunoreactivities and NADPH-diaphorase activity: A light and electron microscopic studyQ48792880
Expression of somatostatin receptor subtypes (SSTR1-5) in Alzheimer's disease brain: an immunohistochemical analysisQ48850710
Cellular expression of ionotropic glutamate receptor subunits on specific striatal neuron types and its implication for striatal vulnerability in glutamate receptor-mediated excitotoxicityQ48955052
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectHuntington's diseaseQ190564
knockout mouseQ1364740
P304page(s)e24467
P577publication date2011-09-02
P1433published inPLOS OneQ564954
P1476titleSomatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice
P478volume6

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cites work (P2860)
Q84531555Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase
Q82676429Colocalization of somatostatin receptors with DARPP-32 in cortex and striatum of rat brain
Q38771048Is Huntington's disease a tauopathy?
Q64269587Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington’s Disease Mice
Q39456064NMDAR hypofunction and somatostatin-expressing GABAergic interneurons and receptors: A newly identified correlation and its effects in schizophrenia
Q28394979Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition
Q30278521Somatostatin 2a receptors are not expressed on functionally identified respiratory neurons in the ventral respiratory column of the rat.
Q38957994Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.
Q33575312The role of the neuropeptide somatostatin on methamphetamine and glutamate-induced neurotoxicity in the striatum of mice

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